KnowLife: A Versatile Approach for Constructing a Large Knowledge Graph for Biomedical Sciences

BACKGROUND: Biomedical knowledge bases (KB’s) have become important assets in life sciences. Prior work on KB construction has three major limitations. First, most biomedical KBs are manually built and curated, and cannot keep up with the rate at which new findings are published. Second, for automatic information extraction (IE), the text genre of choice has been scientific publications, neglecting sources like health portals and online communities. Third, most prior work on IE has focused on the molecular level or chemogenomics only, like protein-protein interactions or gene-drug relationships, or solely address highly specific topics such as drug effects. RESULTS: We address these three limitations by a versatile and scalable approach to automatic KB construction. Using a small number of seed facts for distant supervision of pattern-based extraction, we harvest a huge number of facts in an automated manner without requiring any explicit training. We extend previous techniques for pattern-based IE with confidence statistics, and we combine this recall-oriented stage with logical reasoning for consistency constraint checking to achieve high precision. To our knowledge, this is the first method that uses consistency checking for biomedical relations. Our approach can be easily extended to incorporate additional relations and constraints. We ran extensive experiments not only for scientific publications, but also for encyclopedic health portals and online communities, creating different KB’s based on different configurations. We assess the size and quality of each KB, in terms of number of facts and precision. The best configured KB, KnowLife, contains more than 500,000 facts at a precision of 93% for 13 relations covering genes, organs, diseases, symptoms, treatments, as well as environmental and lifestyle risk factors. CONCLUSION: KnowLife is a large knowledge base for health and life sciences, automatically constructed from different Web sources. As a unique feature, KnowLife is harvested from different text genres such as scientific publications, health portals, and online communities. Thus, it has the potential to serve as one-stop portal for a wide range of relations and use cases. To showcase the breadth and usefulness, we make the KnowLife KB accessible through the health portal (http://knowlife.mpi-inf.mpg.de). ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12859-015-0549-5) contains supplementary material, which is available to authorized users

Discriminative and informative features for biomolecular text mining with ensemble feature selection

Motivation: In the field of biomolecular text mining, black box behavior of machine learning systems currently limits understanding of the true nature of the predictions. However, feature selection (FS) is capable of identifying the most relevant features in any supervised learning setting, providing insight into the specific properties of the classification algorithm. This allows us to build more accurate classifiers while at the same time bridging the gap between the black box behavior and the end-user who has to interpret the results

Corporate Smart Content Evaluation

Nowadays, a wide range of information sources are available due to the evolution of web and collection of data. Plenty of these information are consumable and usable by humans but not understandable and processable by machines. Some data may be directly accessible in web pages or via data feeds, but most of the meaningful existing data is hidden within deep web databases and enterprise information systems. Besides the inability to access a wide range of data, manual processing by humans is effortful, error-prone and not contemporary any more. Semantic web technologies deliver capabilities for machine-readable, exchangeable content and metadata for automatic processing of content. The enrichment of heterogeneous data with background knowledge described in ontologies induces re-usability and supports automatic processing of data. The establishment of “Corporate Smart Content” (CSC) - semantically enriched data with high information content with sufficient benefits in economic areas - is the main focus of this study. We describe three actual research areas in the field of CSC concerning scenarios and datasets applicable for corporate applications, algorithms and research. Aspect- oriented Ontology Development advances modular ontology development and partial reuse of existing ontological knowledge. Complex Entity Recognition enhances traditional entity recognition techniques to recognize clusters of related textual information about entities. Semantic Pattern Mining combines semantic web technologies with pattern learning to mine for complex models by attaching background knowledge. This study introduces the afore-mentioned topics by analyzing applicable scenarios with economic and industrial focus, as well as research emphasis. Furthermore, a collection of existing datasets for the given areas of interest is presented and evaluated. The target audience includes researchers and developers of CSC technologies - people interested in semantic web features, ontology development, automation, extracting and mining valuable information in corporate environments. The aim of this study is to provide a comprehensive and broad overview over the three topics, give assistance for decision making in interesting scenarios and choosing practical datasets for evaluating custom problem statements. Detailed descriptions about attributes and metadata of the datasets should serve as starting point for individual ideas and approaches

Ontology Enrichment from Free-text Clinical Documents: A Comparison of Alternative Approaches

While the biomedical informatics community widely acknowledges the utility of domain ontologies, there remain many barriers to their effective use. One important requirement of domain ontologies is that they achieve a high degree of coverage of the domain concepts and concept relationships. However, the development of these ontologies is typically a manual, time-consuming, and often error-prone process. Limited resources result in missing concepts and relationships, as well as difficulty in updating the ontology as domain knowledge changes. Methodologies developed in the fields of Natural Language Processing (NLP), Information Extraction (IE), Information Retrieval (IR), and Machine Learning (ML) provide techniques for automating the enrichment of ontology from free-text documents. In this dissertation, I extended these methodologies into biomedical ontology development. First, I reviewed existing methodologies and systems developed in the fields of NLP, IR, and IE, and discussed how existing methods can benefit the development of biomedical ontologies. This previously unconducted review was published in the Journal of Biomedical Informatics. Second, I compared the effectiveness of three methods from two different approaches, the symbolic (the Hearst method) and the statistical (the Church and Lin methods), using clinical free-text documents. Third, I developed a methodological framework for Ontology Learning (OL) evaluation and comparison. This framework permits evaluation of the two types of OL approaches that include three OL methods. The significance of this work is as follows: 1) The results from the comparative study showed the potential of these methods for biomedical ontology enrichment. For the two targeted domains (NCIT and RadLex), the Hearst method revealed an average of 21% and 11% new concept acceptance rates, respectively. The Lin method produced a 74% acceptance rate for NCIT; the Church method, 53%. As a result of this study (published in the Journal of Methods of Information in Medicine), many suggested candidates have been incorporated into the NCIT; 2) The evaluation framework is flexible and general enough that it can analyze the performance of ontology enrichment methods for many domains, thus expediting the process of automation and minimizing the likelihood that key concepts and relationships would be missed as domain knowledge evolves

Design of a Controlled Language for Critical Infrastructures Protection

We describe a project for the construction of controlled language for critical infrastructures protection (CIP). This project originates from the need to coordinate and categorize the communications on CIP at the European level. These communications can be physically represented by official documents, reports on incidents, informal communications and plain e-mail. We explore the application of traditional library science tools for the construction of controlled languages in order to achieve our goal. Our starting point is an analogous work done during the sixties in the field of nuclear science known as the Euratom Thesaurus.JRC.G.6-Security technology assessmen

Automatic Summarization

It has now been 50 years since the publication of Luhn’s seminal paper on automatic summarization. During these years the practical need for automatic summarization has become increasingly urgent and numerous papers have been published on the topic. As a result, it has become harder to find a single reference that gives an overview of past efforts or a complete view of summarization tasks and necessary system components. This article attempts to fill this void by providing a comprehensive overview of research in summarization, including the more traditional efforts in sentence extraction as well as the most novel recent approaches for determining important content, for domain and genre specific summarization and for evaluation of summarization. We also discuss the challenges that remain open, in particular the need for language generation and deeper semantic understanding of language that would be necessary for future advances in the field

Knowledge Expansion of a Statistical Machine Translation System using Morphological Resources

Translation capability of a Phrase-Based Statistical Machine Translation (PBSMT) system mostly depends on parallel data and phrases that are not present in the training data are not correctly translated. This paper describes a method that efficiently expands the existing knowledge of a PBSMT system without adding more parallel data but using external morphological resources. A set of new phrase associations is added to translation and reordering models; each of them corresponds to a morphological variation of the source/target/both phrases of an existing association. New associations are generated using a string similarity score based on morphosyntactic information. We tested our approach on En-Fr and Fr-En translations and results showed improvements of the performance in terms of automatic scores (BLEU and Meteor) and reduction of out-of-vocabulary (OOV) words. We believe that our knowledge expansion framework is generic and could be used to add different types of information to the model.JRC.G.2-Global security and crisis managemen