4,686 research outputs found
Investigating the Innate Immune Systems of Bats and Their Roles as Zoonotic Viral Reservoirs
The zoonotic spillover of viral pathogens from wild animal reservoirs into human populations remains the leading cause of emerging and re-emerging infectious diseases globally. Bats represent important viral reservoirs, notorious for the diversity and richness of the viruses they host, several of which are highly pathogenic when transmitted to humans. Remarkably, bats appear to host an abundance of these viruses without exhibiting any clinical signs of disease. A dominant hypothesis for this ability suggests that bats can control viral replication early in the innate immune response, which acts as the first line of defence against infection. However, bat immunology remains fundamentally understudied, largely due to their high species diversity and the lack of accessible reagents required for bat research. Therefore, in this work we explored and characterised key components of bat innate immunity to gain a better understanding of bats as viral reservoirs and contribute to the currently limited literature. Here, we demonstrated the in vitro transcriptomic response of the bat model species, Pteropus alecto (P.alecto) upon stimulation with the bat henipavirus Cedar virus and also with a type III bat interferon (paIFNĪ»). These investigations highlighted key transcripts, some of which were immune-related, in the response of bats to the separate stimuli and presents a foundation for further research into significant genes concerned in bat viral infection. Building from genome-wide transcriptomics, three distinctive bat innate immune genes representative of different stages of interferon signalling were selected for comparative genomics and functional characterisation. Our work demonstrated the conservation of genes between bats and humans, including IRF7, IFIT5 and IFI35. Specific findings for IRF7 included its successful translocation to the cell nucleus upon stimulation. IFIT5 and IFI35 were specifically selected for exploration due to previous research demonstrating the respective antiviral and conflicting anti- or pro-viral roles of these genes in humans. Significantly, our research demonstrated the direct antiviral action of P.alecto IFIT5 against negative-sense RNA viruses. Collectively, our findings offer valuable contributions to the field of bat antiviral immunity and provide the framework for future investigative studies into the role and function of the bat innate immune system and bat viral tolerance mechanisms
NURSING AND MIDWIFERY STUDENTSā LENS: CONNECTING THEORETICAL KNOWLEDGE WITH CLINICAL PRACTICE: AN INTERPRETATIVE PHENOMENOLOGICAL STUDY
Aim: To explore and critically analyse the strategies employed by final-year BSc pre-registration nursing and midwifery students at an inner London university to connect theoretical knowledge with clinical practice, to promote their learning and professional development. Background: Navigating the theory-practice gap has been a significant challenge for nursing and midwifery students. While there are many perspectives from academics and clinicians, how theoretical knowledge is connected with clinical practice is rarely discussed and studied from the studentsā perspectives. Design: Interpretative phenomenological analysis was used to understand nursing and midwifery students' experiences in connecting theoretical knowledge with clinical practice. Rather than attempting to establish objective truth, this thesis focused on participantsā subjective experiences. Method: This study employed a qualitative research design. The data was obtained using semi-structured interviews and analysed using an inductive approach. The study population included (n=12) pre-registration nursing and midwifery students enrolled on a Bachelor of Science programs. Findings: Four themes emerged (1) Complexity of embodied knowledge; (2) Sensing the meaning of personal and professional learning; (3) Demographic attributes and self-understanding; (4) Sense-making of COVID-19. Conclusion: The process by which pre-registration nursing and midwifery students connect theoretical knowledge with clinical practice is complex and multifaceted. It intersects with other factors and cannot be understood in isolation. This interconnectedness necessitates a thorough examination of all the variables involved
āNot the story you want, Iām sureā: Mental health recovery and the narratives of people from marginalised communities
Background: The dominant narrative in mental health policy and practice has shifted in the 21st century from one of chronic ill health or incurability to an orientation towards recovery. A recovery-based approach is now the most frequently used in services in the Global North, and its relevance has also been explored in Global South settings. Despite the ubiquity of the recovery approach, people experiencing poverty, homelessness, intersecting oppressions (based for example on race, ethnicity, gender, sexuality or ability), and other forms of social marginalisation remain under-represented within recovery-oriented research. More inclusive research has been called for to ensure that knowledge of recovery processes is not based solely on the experiences of the relatively well-resourced.
Personal narratives of recovery from mental distress have played a central role in the establishment of the recovery approach within mental health policy and practice. Originating in survivor/service-user movements, the use of ārecovery narrativesā has now become widespread for diverse purposes, including staff training to improve service delivery and increase empathy, public health campaigns to challenge stigma, online interventions to increase access to self-care resources, and as a distinctive feature of peer support. Research suggests that recovery-focused narratives can have benefits and also risks for narrators and recipients. At the same time, the elicitation of such narratives by healthcare researchers, educators and practitioners has been problematised by survivor-researchers and other critical theorists, as a co-option of lived experience for neoliberal purposes.
Following a systematic review of empirical research studies undertaken on characteristics of recovery narratives (presented in Chapter 4), a need for empirical research on the narratives of people from socially marginalised groups was identified. What kinds of stories might we/they be telling, and what are their experiences of telling their stories? What do their experiences tell us about the use of stories within a recovery approach?
Aim: Drawing on a body of critical scholarship, my aim is to conduct an empirical inquiry into (i) characteristics of recovery stories told by people from socially marginalised groups, and (ii) their experiences of telling their stories in formal and everyday settings.
Method: I undertook a critical narrative inquiry based on the stories of 77 people from marginalised groups, collected in the context of a wider study. This comprised narratives from people with lived experience of mental distress who additionally met one or more of the following criteria: (i) had experiences of psychosis; (ii) were from Black, Asian and other minoritised ethnic communities; (iii) are under-served by services (operationalised as lesbian, gay, bi, trans, queer + communities (LGBTQ+) or people identified as having multiple and complex needs); or (iv) had peer support roles. Two-part interviews were conducted (18 conducted by me). Part A consisted of an open-ended question designed to elicit a narrative, and part B was a semi-structured interview inviting participants to reflect on their experiences of telling their recovery stories in different contexts. Following Riessmanās analytical approach, I undertook three forms of analysis: a structural narrative analysis of Part A across the dataset (informed by a preliminary conceptual framework developed in Chapter 4); a thematic analysis of Part B where participants additionally reflected on telling their stories; and an in-depth performative narrative analysis of two accounts (parts A and B) from people with multiple and complex needs.
Findings: In a structural analysis of Part A, the recovery narratives told by people from marginalised groups were found to be diverse and multidimensional. Most (97%) could be characterised by the nine dimensions described in the preliminary conceptual framework (Genre; Positioning; Emotional Tone; Relationship with Recovery; Trajectory; Turning Points; Narrative Sequence; Protagonists; and Use of Metaphors). Each dimension of the framework contained a number of different types. These were expanded as a result of the structural analysis to contain more types: for example, a ācyclicalā type of trajectory was added), and a more comprehensive typology of recovery narratives was produced. Two narratives were found to be āoutliersā, in that their structure, form and content could not adequately be described by the majority of existing dimensions and types. These served as exemplars of the frameworkās limitations.
In a thematic analysis of Part B, my overarching finding was that power differentials between narrators and recipients could be seen as the key factor affecting participantsā experiences of telling their recovery stories in formal and everyday settings. Four themes describing the possibilities and problems raised by telling their stories were identified: (i) āChallenging the status quoā; (ii) āRisky consequencesā; (iii) āProducing acceptable storiesā and (iv) āUntellable storiesā.
In a performative analysis of two narratives of people with multiple and complex needs (Parts A and B), I found two contrasting ways of responding to the invitation to tell a recovery story: a ānarrative of personal lackā and a ānarrative of resistanceā. I demonstrate how the genre of ārecovery narrativeā, with its focus on transformation at the level of personal identity, may function to occlude social and structural causes of distress, and reinforce ideas of personal responsibility for ongoing distress in the face of unchanging living conditions.
Conclusion: The recovery narratives of people from socially marginalised groups are diverse and multidimensional. Told in some contexts, they may hold power to challenge the status quo. However, telling stories of lived experience and recovery is risky, and there may be pressure on narrators to produce āacceptableā stories, or to omit or de-emphasise experiences which challenge dominant cultural narratives. A recovery-based approach to the use of lived experience narratives in research and practice may be contributing towards an over-emphasis on individualist approaches to the reduction of distress. This over-emphasis can be seen to reflect what has been identified as a global trend towards the āinstrumentalā use of personal narratives for utilitarian purposes based on market values. Attention to power differentials and structural as well as agentic factors is vital to ensure that the use of narratives in research and practice does not contribute towards a decontextualised, reductionist form of recovery which pays insufficient attention to the economic, institutional and political injustices that people experiencing mental distress may systematically endure. A sensitive and socially just use of lived experience narratives will remain alert to a variety of power dimensions present within the contexts in which they are shared and hear
Tradition and Innovation in Construction Project Management
This book is a reprint of the Special Issue 'Tradition and Innovation in Construction Project Management' that was published in the journal Buildings
Decolonising Higher Education in the Era of Globalisation and Internationalisation
Conceived within a context of transdisciplinarity and pluriversalism, and in rigorous response to the Eurocentric, globalising and nationalising structures of power that undergird and inhabit contemporary praxis in higher education ā especially in African higher education ā this collection of essays brings to the on-going discourse on decolonisation fresh, rich, probing and multilayered perspectives that should accelerate the process of decolonisation, not only in higher education in Africa, but also in the global imaginary. A remarkable, courageous and potentially revolutionary achievement, this book deserves a special place on curricula throughout the world of higher education
Latin America in Times of Turbulence: Presidentialism under Stress
This book accounts for and analyses the latest developments in Latin American presidential democracies, with a special focus on political institutions. The stellar line-up of renowned scholars of Latin American politics and institutions from Latin America, Europe, and the United States offer new insights into how democratic institutions have operated within the critical context that marked the political and social life of the region in the last few years: the eruption of popular protest and discontent, the widespread distrust of political institutions, and, of course, the COVID-19 pandemic. Combining different methodological approaches, including cross-national studies, small-N studies, case studies, and quantitative and qualitative data, the contributions cluster around three themes: the problem with fixed terms and other features of presidentialism, inter-institutional relations and executive accountability, and old and new threats to democracy in these times of turmoil. The volume concludes with an assessment of the political consequences of the COVID-19 pandemic in Latin America.
Beyond current scholars and students of comparative political scientists, Latin America in Times of Turbulence will be of great interest to a wide spectrum of readers interested in comparative systems of government, democracy studies, and Latin American politics more generally
Expectations and expertise in artificial intelligence: specialist views and historical perspectives on conceptualisation, promise, and funding
Artificial intelligenceās (AI) distinctiveness as a technoscientific field that imitates the ability to think went through a resurgence of interest post-2010, attracting a flood of scientific and popular expectations as to its utopian or dystopian transformative consequences. This thesis offers observations about the formation and dynamics of expectations based on documentary material from the previous periods of perceived AI hype (1960-1975 and 1980-1990, including in-between periods of perceived dormancy), and 25 interviews with UK-based AI specialists, directly involved with its development, who commented on the issues during the crucial period of uncertainty (2017-2019) and intense negotiation through which AI gained momentum prior to its regulation and relatively stabilised new rounds of long-term investment (2020-2021). This examination applies and contributes to longitudinal studies in the sociology of expectations (SoE) and studies of experience and expertise (SEE) frameworks, proposing a historical sociology of expertise and expectations framework. The research questions, focusing on the interplay between hype mobilisation and governance, are: (1) What is the relationship between AI practical development and the broader expectational environment, in terms of funding and conceptualisation of AI? (2) To what extent does informal and non-developer assessment of expectations influence formal articulations of foresight? (3) What can historical examinations of AIās conceptual and promissory settings tell about the current rebranding of AI?
The following contributions are made: (1) I extend SEE by paying greater attention to the interplay between technoscientific experts and wider collective arenas of discourse amongst non-specialists and showing how AIās contemporary research cultures are overwhelmingly influenced by the hype environment but also contribute to it. This further highlights the interaction between competing rationales focusing on exploratory, curiosity-driven scientific research against exploitation-oriented strategies at formal and informal levels. (2) I suggest benefits of examining promissory environments in AI and related technoscientific fields longitudinally, treating contemporary expectations as historical products of sociotechnical trajectories through an authoritative historical reading of AIās shifting conceptualisation and attached expectations as a response to availability of funding and broader national imaginaries. This comes with the benefit of better perceiving technological hype as migrating from social group to social group instead of fading through reductionist cycles of disillusionment; either by rebranding of technical operations, or by the investigation of a given field by non-technical practitioners. It also sensitises to critically examine broader social expectations as factors for shifts in perception about theoretical/basic science research transforming into applied technological fields. Finally, (3) I offer a model for understanding the significance of interplay between conceptualisations, promising, and motivations across groups within competing dynamics of collective and individual expectations and diverse sources of expertise
Understanding an Urban Black Worldview: A Phenomenological Examination of 2020
This action research project was designed to surface and codify a worldview that emerged among black people as a result of the traumatic phenomena of 2020. The program sought to help white pastors in New Yorkās Lower Hudson Valley recognize this new worldview, understand its implications, and desire to intentionally develop their level of Cultural Competence to more effectively counsel and disciple black congregants holding this worldview. The detrimental effects of the phenomena of 2020 exacerbated existing trauma caused by social and institutional racism and resulted in an altered worldview among urban blacks affecting relationships in communities and within church congregations. A practical, immersive intervention program was developed in which ten white, majority culture evangelical ministers participated in a 30-day phenomenologically based lifestyle immersion in black history and urban culture. Group discussions, surveys, and cultural immersion allowed pastors to experience the phenomena of 2020 and black history through the eyes of the minority sub-culture. The pastors grew in Cultural Intelligence and their desire to develop greater Cultural Competence intentionally. It is hoped that this project will inspire and guide a growing examination of identifiable, quantifiable, common-core worldviews by qualified evangelicals within their own sub-cultures. A growing, evolving compendium of cultural knowledge that builds Cultural Intelligence and leads to Cultural Competence within the Evangelical community would greatly benefit the kingdom
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