High-order regularized regression in Electrical Impedance Tomography

We present a novel approach for the inverse problem in electrical impedance tomography based on regularized quadratic regression. Our contribution introduces a new formulation for the forward model in the form of a nonlinear integral transform, that maps changes in the electrical properties of a domain to their respective variations in boundary data. Using perturbation theory the transform is approximated to yield a high-order misfit unction which is then used to derive a regularized inverse problem. In particular, we consider the nonlinear problem to second-order accuracy, hence our approximation method improves upon the local linearization of the forward mapping. The inverse problem is approached using Newton's iterative algorithm and results from simulated experiments are presented. With a moderate increase in computational complexity, the method yields superior results compared to those of regularized linear regression and can be implemented to address the nonlinear inverse problem

Methods for the Electrical Impedance Tomography Inverse Problem: Deep Learning and Regularization with Wavelets

Electrical impedance tomography, also known as EIT, is a type of diffusive imaging modality that is non-invasive, radiation-free, and cost-effective for recovering electrical properties within a closed domain from surface measurements. The process involves injecting electrical current into a set of electrodes to measure the voltage on the smooth surface of the domain. The recovered EIT images show how well different materials or tissues within the domain conduct or impede electrical flow, which is helpful in detecting and locating anomalies. For the EIT inverse problem, it is challenging to recover reliable and resolvable electrical conductivity images since it is highly nonlinear and severely ill-posed, especially when the data is corrupted with noise. To address this issue, we propose (1) a wavelet-based modified Gauss-Newton (WGN) method that uses wavelets as a form of regularization and parameter reduction. In (1), we enforce regularization through the use of wavelet coefficients by projecting the original formulation to the wavelet domain and then only retaining the wavelet coefficients of highest power. The projected wavelet formulation is of a smaller dimension and, therefore, shows promise in improving the ill-posedness of the EIT inverse problem. Different wavelet families are implemented to capture localized features, smoothness, and irregularities within the domain. In addition, we also propose (2) a novel deep learning algorithm to solve the EIT inverse problem. In (2), we develop a deep neural network (DNN) with multiple transposed convolutional layers and activation functions to recover the EIT images. The DNN is first trained on a large set of EIT images and data, and then we recover EIT images in real-time from the trained DNN. We compare the image reconstructions from the DNN with a benchmark algorithm. For model validation, we employed a set of synthetic examples with various anomalies to test the performance and efficacy of both the DNN and WGN method. The results from both methods show promise in improving EIT image reconstructions

Analytical and Iterative Regularization Methods for Nonlinear Ill-posed Inverse Problems: Applications to Diffuse Optical and Electrical Impedance Tomography

Electrical impedance tomography (EIT) and Diffuse Optical Tomography (DOT) are imaging methods that have been gaining more popularity due to their ease of use and non-ivasiveness. EIT and DOT can potentially be used as alternatives to traditional imaging techniques, such as computed tomography (CT) scans, to reduce the damaging effects of radiation on tissue. The process of imaging using either EIT or DOT involves measuring the ability for tissue to impede electrical flow or absorb light, respectively. For EIT, the inner distribution of resistivity, which corresponds to different resistivity properties of different tissues, is estimated from the voltage potentials measured on the boundary of the object being imaged. In DOT, the optical properties of the tissue, mainly scattering and absorption, are estimated by measuring the light on the boundary of the tissue illuminated by a near-infrared source at the tissue\u27s surface. In this dissertation, we investigate a direct method for solving the EIT inverse problem using mollifier regularization, which is then modified and extended to solve the inverse problem in DOT. First, the mollifier method is formulated and then its efficacy is verified by developing an appropriate algorithm. For EIT and DOT, a comprehensive numerical and computational comparison, using several types of regularization techniques ranging from analytical to iterative to statistical method, is performed. Based on the comparative results using the aforementioned regularization methods, a novel hybrid method combining the deterministic (mollifier and iterative) and statistical (iterative and statistical) is proposed. The efficacy of the proposed method is then further investigated via simulations and using experimental data for damage detection in concrete

Multifrequency methods for Electrical Impedance Tomography

Multifrequency Electrical Impedance Tomography (MFEIT) is an emerging imaging modality which exploits the dependence of tissue impedance on frequency to recover images of conductivity. Given the low cost and portability of EIT scanners, MFEIT could provide emergency diagnosis of pathologies such as acute stroke, brain injury and breast cancer. Whereas time-difference, or dynamic, EIT is an established technique for monitoring lung ventilation, MFEIT has received less attention in the literature, and the imaging methodology is at an early stage of development. MFEIT holds the unique potential to form images from static data, but high sensitivity to noise and modelling errors must be overcome. The subject of this doctoral thesis is the investigation of novel techniques for including spectral information in the image reconstruction process. The aim is to improve the ill-posedness of the inverse problem and deliver the first imaging methodology with sufficient robustness for clinical application. First, a simple linear model for the conductivity is defined and a simultaneous multifrequency method is developed. Second, the method is applied to a realistic numerical model of a human head, and the robustness to modelling errors is investigated. Third, a combined image reconstruction and classification method is developed, which allows for the simultaneous recovery of the conductivity and the spectral information by introducing a Gaussian-mixture model for the conductivity. Finally, a graph-cut image segmentation technique is integrated in the imaging method. In conclusion, this work identifies spectral information as a key resource for producing MFEIT images and points to a new direction for the development of MFEIT algorithms

Data driven regularization models of non-linear ill-posed inverse problems in imaging

Imaging technologies are widely used in application fields such as natural sciences, engineering, medicine, and life sciences. A broad class of imaging problems reduces to solve ill-posed inverse problems (IPs). Traditional strategies to solve these ill-posed IPs rely on variational regularization methods, which are based on minimization of suitable energies, and make use of knowledge about the image formation model (forward operator) and prior knowledge on the solution, but lack in incorporating knowledge directly from data. On the other hand, the more recent learned approaches can easily learn the intricate statistics of images depending on a large set of data, but do not have a systematic method for incorporating prior knowledge about the image formation model. The main purpose of this thesis is to discuss data-driven image reconstruction methods which combine the benefits of these two different reconstruction strategies for the solution of highly nonlinear ill-posed inverse problems. Mathematical formulation and numerical approaches for image IPs, including linear as well as strongly nonlinear problems are described. More specifically we address the Electrical impedance Tomography (EIT) reconstruction problem by unrolling the regularized Gauss-Newton method and integrating the regularization learned by a data-adaptive neural network. Furthermore we investigate the solution of non-linear ill-posed IPs introducing a deep-PnP framework that integrates the graph convolutional denoiser into the proximal Gauss-Newton method with a practical application to the EIT, a recently introduced promising imaging technique. Efficient algorithms are then applied to the solution of the limited electrods problem in EIT, combining compressive sensing techniques and deep learning strategies. Finally, a transformer-based neural network architecture is adapted to restore the noisy solution of the Computed Tomography problem recovered using the filtered back-projection method