Comparison of automated post-processing techniques for measurement of body surface area from 3D photonic scans

Body surface area (BSA) measurement is important in engineering and medicine fields to determine parameters for various applications. Three-dimensional scanning techniques may be used to acquire the BSA directly. Nevertheless, the raw data obtained from 3D scanning usually requires some manual post-processing which is time-consuming and requires technical expertise. Automated post-processing of 3D scans enables expedient BSA calculation with minimal technical expertise. The purpose of this research was to compare the accuracy and reliability of three different automated post-processing techniques including Stitched Puppet (SP), Poisson surface reconstruction (PSR), and screened Poisson surface reconstruction (SPSR) using manual post-processing as the criterion. Twenty-nine participants were scanned twice, and raw data were processed with the manual operation and automated techniques to acquire BSAs separately. The reliability of BSAs acquired from these approaches was represented by the relative technical error of measurements (TEM). Pearson’s regressions were applied to correct BSAs acquired from the automated techniques. The limits of agreement (LOA) were used to quantify the accuracy of BSAs acquired from the automated techniques and corrected by regression models. The reliability (relative TEM) of BSAs obtained from PSR, SPSR and SP were 0.32%, 0.30%, 0.82% respectively. After removing bias with the regression models, the LOA for PSR, SPSR and SP were (-0.0134 m2, 0.0135 m2), ±0.0131 m2, ±0.0573 m2 respectively. It is concluded that PSR and SPSR are good alternative approaches to manual post-processing for applications that need reliable and accurate measurements of BSAs with large populations

Automated body volume acquisitions from 3D structured-light scanning

Whole-body volumes and segmental volumes are highly related to the health and medical condition of individuals. However, the traditional manual post-processing of raw 3D scanned data is time-consuming and needs technical expertise. The purpose of this study was to develop bespoke software for obtaining whole-body volumes and segmental volumes from raw 3D scanned data automatically and to establish its accuracy and reliability. The bespoke software applied Stitched Puppet model fitting techniques to deform template models to fit the 3D raw scanned data to identify the segmental endpoints and determine their locations. Finally, the bespoke software used the location information of segmental endpoints to set segmental boundaries on the reconstructed meshes and to calculate body volume. The whole-body volumes and segmental volumes (head & neck, torso, arms, and legs) of 29 participants processed by the traditional manual operation were regarded as the references and compared to the measurements obtained with the bespoke software using the intra-method and inter-method relative technical errors of measurement. The results showed that the errors in whole-body volumes and most segmental volumes acquired from the bespoke software were less than 5%. Overall, the bespoke software developed in this study can complete the post-processing tasks without any technical expertise, and the obtained whole-body volumes and segmental volumes can achieve good accuracy for some applications in health and medicine

Raman Spectroscopy Detects Distant Invasive Brain Cancer Cells Centimeters beyond MRI Capability in Humans

Surgical treatment of brain cancer is limited by the inability of current imaging capabilities such as magnetic resonance imaging (MRI) to detect the entirety of this locally invasive cancer. This results in residual cancer cells remaining following surgery, leading to recurrence and death. We demonstrate that intraoperative Raman spectroscopy can detect invasive cancer cells centimeters beyond pathological T1-contrast-enhanced and T2-weighted MRI signals. This intraoperative optical guide can be used to detect invasive cancer cells and minimize post-surgical cancer burden. The detection of distant invasive cancer cells beyond MRI signal has the potential to increase the effectiveness of surgery and directly lengthen patient survival

Sub-clinical assessment of atopic dermatitis severity using angiographic optical coherence tomography

Measurement of sub-clinical atopic dermatitis (AD) is important for determining how long therapies should be continued after clinical clearance of visible AD lesions. An important biomarker of sub-clinical AD is epidermal hypertrophy, the structural measures of which often make optical coherence tomography (OCT) challenging due to the lack of a clearly delineated dermal-epidermal junction in AD patients. Alternatively, angiographic OCT measurements of vascular depth and morphology may represent a robust biomarker for quantifying the severity of clinical and sub-clinical AD. To investigate this, angiographic data sets were acquired from 32 patients with a range of AD severities. Deeper vascular layers within skin were found to correlate with increasing clinical severity. Furthermore, for AD patients exhibiting no clinical symptoms, the superficial plexus depth was found to be significantly deeper than healthy patients at both the elbow (p = 0.04) and knee (p < 0.001), suggesting that sub-clinical changes in severity can be detected. Furthermore, the morphology of vessels appeared altered in patients with severe AD, with significantly different vessel diameter, length, density and fractal dimension. These metrics provide valuable insight into the sub-clinical severity of the condition, allowing the effects of treatments to be monitored past the point of clinical remission

The use of consumer depth cameras for 3D surface imaging of people with obesity: a feasibility study

Objective Three dimensional (3D) surface imaging is a viable alternative to traditional body morphology measures, but the feasibility of using this technique with people with obesity has not been fully established. Therefore, the aim of this study was to investigate the validity, repeatability and acceptability of a consumer depth camera 3D surface imaging system in imaging people with obesity. Methods The concurrent validity of the depth camera based system was investigated by comparing measures of mid-trunk volume to a gold-standard. The repeatability and acceptability of the depth camera system was assessed in people with obesity at a clinic. Results There was evidence of a fixed systematic difference between the depth camera system and the gold standard but excellent correlation between volume estimates (r2 = 0.997), with little evidence of proportional bias. The depth camera system was highly repeatable – low typical error (0.192 L), high intraclass correlation coefficient (>0.999) and low technical error of measurement (0.64%). Depth camera based 3D surface imaging was also acceptable to people with obesity. Conclusion It is feasible (valid, repeatable and acceptable) to use a low cost, flexible 3D surface imaging system to monitor the body size and shape of people with obesity in a clinical setting

The Boston University Photonics Center annual report 2016-2017

This repository item contains an annual report that summarizes activities of the Boston University Photonics Center in the 2016-2017 academic year. The report provides quantitative and descriptive information regarding photonics programs in education, interdisciplinary research, business innovation, and technology development. The Boston University Photonics Center (BUPC) is an interdisciplinary hub for education, research, scholarship, innovation, and technology development associated with practical uses of light.This has undoubtedly been the Photonics Center’s best year since I became Director 10 years ago. In the following pages, you will see highlights of the Center’s activities in the past year, including more than 100 notable scholarly publications in the leading journals in our field, and the attraction of more than 22 million dollars in new research grants/contracts. Last year I had the honor to lead an international search for the first recipient of the Moustakas Endowed Professorship in Optics and Photonics, in collaboration with ECE Department Chair Clem Karl. This professorship honors the Center’s most impactful scholar and one of the Center’s founding visionaries, Professor Theodore Moustakas. We are delighted to haveawarded this professorship to Professor Ji-Xin Cheng, who joined our faculty this year.The past year also marked the launch of Boston University’s Neurophotonics Center, which will be allied closely with the Photonics Center. Leading that Center will be a distinguished new faculty member, Professor David Boas. David and I are together leading a new Neurophotonics NSF Research Traineeship Program that will provide $3M to promote graduate traineeships in this emerging new field. We had a busy summer hosting NSF Sites for Research Experiences for Undergraduates, Research Experiences for Teachers, and the BU Student Satellite Program. As a community, we emphasized the theme of “Optics of Cancer Imaging” at our annual symposium, hosted by Darren Roblyer. We entered a five-year second phase of NSF funding in our Industry/University Collaborative Research Center on Biophotonic Sensors and Systems, which has become the centerpiece of our translational biophotonics program. That I/UCRC continues to focus on advancing the health care and medical device industries

New Trends and Applications in Femtosecond Laser Micromachining

This book contains the scientific contributions to the Special Issue entitled: "New Trends and Applications in Femtosecond Laser Micromachining". It covers an array of subjects, from the basics of femtosecond laser micromachining to specific applications in a broad spectra of fields such biology, photonics and medicine

Material modifications due to nonlinear effects created by multiphoton absorption in single crystalline silicon

Material modification inside its bulk via high powered lasers involves much more than just heat transfer and melting of materials. It entails with it complex nonlinear physical phenomena such as multiphoton absorption, self-phase modulation, and self-focussing, amongst many others. These phenomena occur only with ultrafast lasers at very high intensities. Realising subsurface or bulk modifications in semiconductors such as silicon, opens up new avenues in the fields of optoelectronics and optical computation with the potential of increasing current computational speeds by orders of magnitude. The technology of three dimensional volume modification in materials via ultrafast lasers and nonlinear physics, is however, still in its nascent stages. This work explores the possibility of realising bulk modification in silicon and other polymers, and as well as their integration with optoelectronic devices; thus paving way for the future of optical computation

Advances in femtosecond micromachining and inscription of micro and nano photonic devices

This thesis has focused on three key areas of interest for femtosecond micromachining and inscription. The first area is micromachining where the work has focused on the ability to process highly repeatable, high precision machining with often extremely complex geometrical structures with little or no damage. High aspect ratio features have been demonstrated in transparent materials, metals and ceramics. Etch depth control was demonstrated especially in the work on phase mask fabrication. Practical chemical sensing and microfluidic devices were also fabricated to demonstrate the capability of the techniques developed during this work. The second area is femtosecond inscription. Here, the work has utilised the non-linear absorption mechanisms associated with femtosecond pulse-material interactions to create highly localised refractive index changes in transparent materials to create complex 3D structures. The techniques employed were then utilised in the fabrication of Phase masks and Optical Coherence Tomography (OCT) phantom calibration artefacts both of which show the potential to fill voids in the development of the fields. This especially the case for the OCT phantoms where there exists no previous artefacts of known shape, allowing for the initial specification of parameters associated with the quality of OCT machines that are being taken up across the world in industry and research. Finally the third area of focus was the combination of all of the techniques developed through work in planar samples to create a range of artefacts in optical fibres. The development of techniques and methods for compensating for the geometrical complexities associated with working with the cylindrical samples with varying refractive indices allowed for fundamental inscription parameters to be examined, structures for use as power monitors and polarisers with the optical fibres and finally the combination of femtosecond inscription and ablation techniques to create a magnetic field sensor with an optical fibre coated in Terfenol-D with directional capability. Through the development of understanding, practical techniques and equipment the work presented here demonstrates several novel pieces of research in the field of femtosecond micromachining and inscription that has provided a broad range of related fields with practical devices that were previously unavailable or that would take great cost and time to facilitate

Development of High-speed Optical Coherence Tomography for Time-lapse Non-destructive Characterization of Samples

Optical coherence tomography (OCT) is an established optical imaging modality which can obtain label-free, non-destructive 3D images of samples with micron-scale resolution and millimeter penetration. OCT has been widely adopted for biomedical researches