33,266 research outputs found
Comparison of Brain Networks based on Predictive Models of Connectivity
In this study we adopt predictive modelling to identify simultaneously
commonalities and differences in multi-modal brain networks acquired within
subjects. Typically, predictive modelling of functional connectomes from
structural connectomes explores commonalities across multimodal imaging data.
However, direct application of multivariate approaches such as sparse Canonical
Correlation Analysis (sCCA) applies on the vectorised elements of functional
connectivity across subjects and it does not guarantee that the predicted
models of functional connectivity are Symmetric Positive Matrices (SPD). We
suggest an elegant solution based on the transportation of the connectivity
matrices on a Riemannian manifold, which notably improves the prediction
performance of the model. Randomised lasso is used to alleviate the dependency
of the sCCA on the lasso parameters and control the false positive rate.
Subsequently, the binomial distribution is exploited to set a threshold
statistic that reflects whether a connection is selected or rejected by chance.
Finally, we estimate the sCCA loadings based on a de-noising approach that
improves the estimation of the coefficients. We validate our approach based on
resting-state fMRI and diffusion weighted MRI data. Quantitative validation of
the prediction performance shows superior performance, whereas qualitative
results of the identification process are promising.Comment: 7 pages, 4 figure
Learning and comparing functional connectomes across subjects
Functional connectomes capture brain interactions via synchronized
fluctuations in the functional magnetic resonance imaging signal. If measured
during rest, they map the intrinsic functional architecture of the brain. With
task-driven experiments they represent integration mechanisms between
specialized brain areas. Analyzing their variability across subjects and
conditions can reveal markers of brain pathologies and mechanisms underlying
cognition. Methods of estimating functional connectomes from the imaging signal
have undergone rapid developments and the literature is full of diverse
strategies for comparing them. This review aims to clarify links across
functional-connectivity methods as well as to expose different steps to perform
a group study of functional connectomes
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Preliminary prediction of individual response to electroconvulsive therapy using whole-brain functional magnetic resonance imaging data.
Electroconvulsive therapy (ECT) works rapidly and has been widely used to treat depressive disorders (DEP). However, identifying biomarkers predictive of response to ECT remains a priority to individually tailor treatment and understand treatment mechanisms. This study used a connectome-based predictive modeling (CPM) approach in 122 patients with DEP to determine if pre-ECT whole-brain functional connectivity (FC) predicts depressive rating changes and remission status after ECT (47 of 122 total subjects or 38.5% of sample), and whether pre-ECT and longitudinal changes (pre/post-ECT) in regional brain network biomarkers are associated with treatment-related changes in depression ratings. Results show the networks with the best predictive performance of ECT response were negative (anti-correlated) FC networks, which predict the post-ECT depression severity (continuous measure) with a 76.23% accuracy for remission prediction. FC networks with the greatest predictive power were concentrated in the prefrontal and temporal cortices and subcortical nuclei, and include the inferior frontal (IFG), superior frontal (SFG), superior temporal (STG), inferior temporal gyri (ITG), basal ganglia (BG), and thalamus (Tha). Several of these brain regions were also identified as nodes in the FC networks that show significant change pre-/post-ECT, but these networks were not related to treatment response. This study design has limitations regarding the longitudinal design and the absence of a control group that limit the causal inference regarding mechanism of post-treatment status. Though predictive biomarkers remained below the threshold of those recommended for potential translation, the analysis methods and results demonstrate the promise and generalizability of biomarkers for advancing personalized treatment strategies
Sparse Predictive Structure of Deconvolved Functional Brain Networks
The functional and structural representation of the brain as a complex
network is marked by the fact that the comparison of noisy and intrinsically
correlated high-dimensional structures between experimental conditions or
groups shuns typical mass univariate methods. Furthermore most network
estimation methods cannot distinguish between real and spurious correlation
arising from the convolution due to nodes' interaction, which thus introduces
additional noise in the data. We propose a machine learning pipeline aimed at
identifying multivariate differences between brain networks associated to
different experimental conditions. The pipeline (1) leverages the deconvolved
individual contribution of each edge and (2) maps the task into a sparse
classification problem in order to construct the associated "sparse deconvolved
predictive network", i.e., a graph with the same nodes of those compared but
whose edge weights are defined by their relevance for out of sample predictions
in classification. We present an application of the proposed method by decoding
the covert attention direction (left or right) based on the single-trial
functional connectivity matrix extracted from high-frequency
magnetoencephalography (MEG) data. Our results demonstrate how network
deconvolution matched with sparse classification methods outperforms typical
approaches for MEG decoding
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