Genome Reduction Is Associated with Bacterial Pathogenicity across Different Scales of Temporal and Ecological Divergence.

Emerging bacterial pathogens threaten global health and food security, and so it is important to ask whether these transitions to pathogenicity have any common features. We present a systematic study of the claim that pathogenicity is associated with genome reduction and gene loss. We compare broad-scale patterns across all bacteria, with detailed analyses of Streptococcus suis, an emerging zoonotic pathogen of pigs, which has undergone multiple transitions between disease and carriage forms. We find that pathogenicity is consistently associated with reduced genome size across three scales of divergence (between species within genera, and between and within genetic clusters of S. suis). Although genome reduction is also found in mutualist and commensal bacterial endosymbionts, genome reduction in pathogens cannot be solely attributed to the features of their ecology that they share with these species, that is, host restriction or intracellularity. Moreover, other typical correlates of genome reduction in endosymbionts (reduced metabolic capacity, reduced GC content, and the transient expansion of nonfunctional elements) are not consistently observed in pathogens. Together, our results indicate that genome reduction is a consistent correlate of pathogenicity in bacteria

Stereotactic body radiotherapy for treatment of liver metastasis

В данной работе было изучено методологию планирования VMAT. Роль предварительной обработки топометрии, планирования лечения, планов контроля качества, и доставки лечения пяти пациентам с метастазами в печени в Томском Областном Онкологическом Центре.In this work was study the planning methodology of VMAT. the role of pre-treatment topometry, treatment planning, quality control plans, and delivery of treatment to five patients with liver metastases in the Tomsk Regional Oncology Center