9 research outputs found

    Linguistic- and Acoustic-based Automatic Dementia Detection using Deep Learning Methods

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    Dementia can affect a person's speech and language abilities, even in the early stages. Dementia is incurable, but early detection can enable treatment that can slow down and maintain mental function. Therefore, early diagnosis of dementia is of great importance. However, current dementia detection procedures in clinical practice are expensive, invasive, and sometimes inaccurate. In comparison, computational tools based on the automatic analysis of spoken language have the potential to be applied as a cheap, easy-to-use, and objective clinical assistance tool for dementia detection. In recent years, several studies have shown promise in this area. However, most studies focus heavily on the machine learning aspects and, as a consequence, often lack sufficient incorporation of clinical knowledge. Many studies also concentrate on clinically less relevant tasks such as the distinction between HC and people with AD which is relatively easy and therefore less interesting both in terms of the machine learning and the clinical application. The studies in this thesis concentrate on automatically identifying signs of neurodegenerative dementia in the early stages and distinguishing them from other clinical, diagnostic categories related to memory problems: (FMD, MCI, and HC). A key focus, when designing the proposed systems has been to better consider (and incorporate) currently used clinical knowledge and also to bear in mind how these machine-learning based systems could be translated for use in real clinical settings. Firstly, a state-of-the-art end-to-end system is constructed for extracting linguistic information from automatically transcribed spontaneous speech. The system's architecture is based on hierarchical principles thereby mimicking those used in clinical practice where information at both word-, sentence- and paragraph-level is used when extracting information to be used for diagnosis. Secondly, hand-crafted features are designed that are based on clinical knowledge of the importance of pausing and rhythm. These are successfully joined with features extracted from the end-to-end system. Thirdly, different classification tasks are explored, each set up so as to represent the types of diagnostic decision-making that is relevant in clinical practice. Finally, experiments are conducted to explore how to better deal with the known problem of confounding and overlapping symptoms on speech and language from age and cognitive decline. A multi-task system is constructed that takes age into account while predicting cognitive decline. The studies use the publicly available DementiaBank dataset as well as the IVA dataset, which has been collected by our collaborators at the Royal Hallamshire Hospital, UK. In conclusion, this thesis proposes multiple methods of using speech and language information for dementia detection with state-of-the-art deep learning technologies, confirming the automatic system's potential for dementia detection

    The radiological investigation of musculoskeletal tumours : chairperson's introduction

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    Infective/inflammatory disorders

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    A Framework For Enhancing Speaker Age And Gender Classification By Using A New Feature Set And Deep Neural Network Architectures

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    Speaker age and gender classification is one of the most challenging problems in speech processing. Recently with developing technologies, identifying a speaker age and gender has become a necessity for speaker verification and identification systems such as identifying suspects in criminal cases, improving human-machine interaction, and adapting music for awaiting people queue. Although many studies have been carried out focusing on feature extraction and classifier design for improvement, classification accuracies are still not satisfactory. The key issue in identifying speaker鈥檚 age and gender is to generate robust features and to design an in-depth classifier. Age and gender information is concealed in speaker鈥檚 speech, which is liable for many factors such as, background noise, speech contents, and phonetic divergences. In this work, different methods are proposed to enhance the speaker age and gender classification based on the deep neural networks (DNNs) as a feature extractor and classifier. First, a model for generating new features from a DNN is proposed. The proposed method uses the Hidden Markov Model toolkit (HTK) tool to find tied-state triphones for all utterances, which are used as labels for the output layer in the DNN. The DNN with a bottleneck layer is trained in an unsupervised manner for calculating the initial weights between layers, then it is trained and tuned in a supervised manner to generate transformed mel-frequency cepstral coefficients (T-MFCCs). Second, the shared class labels method is introduced among misclassified classes to regularize the weights in DNN. Third, DNN-based speakers models using the SDC feature set is proposed. The speakers-aware model can capture the characteristics of the speaker age and gender more effectively than a model that represents a group of speakers. In addition, AGender-Tune system is proposed to classify the speaker age and gender by jointly fine-tuning two DNN models; the first model is pre-trained to classify the speaker age, and second model is pre-trained to classify the speaker gender. Moreover, the new T-MFCCs feature set is used as the input of a fusion model of two systems. The first system is the DNN-based class model and the second system is the DNN-based speaker model. Utilizing the T-MFCCs as input and fusing the final score with the score of a DNN-based class model enhanced the classification accuracies. Finally, the DNN-based speaker models are embedded into an AGender-Tune system to exploit the advantages of each method for a better speaker age and gender classification. The experimental results on a public challenging database showed the effectiveness of the proposed methods for enhancing the speaker age and gender classification and achieved the state of the art on this database

    Tagungsband der 12. Tagung Phonetik und Phonologie im deutschsprachigen Raum

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    Evaluation of preprocessors for neural network speaker verification

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