Knowledge-Intensive Processes: Characteristics, Requirements and Analysis of Contemporary Approaches

Engineering of knowledge-intensive processes (KiPs) is far from being mastered, since they are genuinely knowledge- and data-centric, and require substantial flexibility, at both design- and run-time. In this work, starting from a scientific literature analysis in the area of KiPs and from three real-world domains and application scenarios, we provide a precise characterization of KiPs. Furthermore, we devise some general requirements related to KiPs management and execution. Such requirements contribute to the definition of an evaluation framework to assess current system support for KiPs. To this end, we present a critical analysis on a number of existing process-oriented approaches by discussing their efficacy against the requirements

Computerization of workflows, guidelines and care pathways: a review of implementation challenges for process-oriented health information systems

There is a need to integrate the various theoretical frameworks and formalisms for modeling clinical guidelines, workflows, and pathways, in order to move beyond providing support for individual clinical decisions and toward the provision of process-oriented, patient-centered, health information systems (HIS). In this review, we analyze the challenges in developing process-oriented HIS that formally model guidelines, workflows, and care pathways. A qualitative meta-synthesis was performed on studies published in English between 1995 and 2010 that addressed the modeling process and reported the exposition of a new methodology, model, system implementation, or system architecture. Thematic analysis, principal component analysis (PCA) and data visualisation techniques were used to identify and cluster the underlying implementation ‘challenge’ themes. One hundred and eight relevant studies were selected for review. Twenty-five underlying ‘challenge’ themes were identified. These were clustered into 10 distinct groups, from which a conceptual model of the implementation process was developed. We found that the development of systems supporting individual clinical decisions is evolving toward the implementation of adaptable care pathways on the semantic web, incorporating formal, clinical, and organizational ontologies, and the use of workflow management systems. These architectures now need to be implemented and evaluated on a wider scale within clinical settings

Possibilistic Information Flow Control for Workflow Management Systems

In workflows and business processes, there are often security requirements on both the data, i.e. confidentiality and integrity, and the process, e.g. separation of duty. Graphical notations exist for specifying both workflows and associated security requirements. We present an approach for formally verifying that a workflow satisfies such security requirements. For this purpose, we define the semantics of a workflow as a state-event system and formalise security properties in a trace-based way, i.e. on an abstract level without depending on details of enforcement mechanisms such as Role-Based Access Control (RBAC). This formal model then allows us to build upon well-known verification techniques for information flow control. We describe how a compositional verification methodology for possibilistic information flow can be adapted to verify that a specification of a distributed workflow management system satisfies security requirements on both data and processes.Comment: In Proceedings GraMSec 2014, arXiv:1404.163

Comparative ergonomic workflow and user experience analysis of MRI versus fluoroscopy-guided vascular interventions:an iliac angioplasty exemplar case study

Purpose A methodological framework is introduced to assess and compare a conventional fluoroscopy protocol for peripheral angioplasty with a new magnetic resonant imaging (MRI)-guided protocol. Different scenarios were considered during interventions on a perfused arterial phantom with regard to time-based and cognitive task analysis, user experience and ergonomics. Methods Three clinicians with different expertise performed a total of 43 simulated common iliac angioplasties (9 fluoroscopic, 34 MRI-guided) in two blocks of sessions. Six different configurations for MRI guidance were tested in the first block. Four of them were evaluated in the second block and compared to the fluoroscopy protocol. Relevant stages’ durations were collected, and interventions were audio-visually recorded from different perspectives. A cued retrospective protocol analysis (CRPA) was undertaken, including personal interviews. In addition, ergonomic constraints in the MRI suite were evaluated. Results Significant differences were found when comparing the performance between MRI configurations versus fluoroscopy. Two configurations [with times of 8.56 (0.64) and 9.48 (1.13) min] led to reduce procedure time for MRI guidance, comparable to fluoroscopy [8.49 (0.75) min]. The CRPA pointed out the main influential factors for clinical procedure performance. The ergonomic analysis quantified musculoskeletal risks for interventional radiologists when utilising MRI. Several alternatives were suggested to prevent potential low-back injuries. Conclusions This work presents a step towards the implementation of efficient operational protocols for MRI-guided procedures based on an integral and multidisciplinary framework, applicable to the assessment of current vascular protocols. The use of first-user perspective raises the possibility of establishing new forms of clinical training and education

MITK-ModelFit: A generic open-source framework for model fits and their exploration in medical imaging -- design, implementation and application on the example of DCE-MRI

Many medical imaging techniques utilize fitting approaches for quantitative parameter estimation and analysis. Common examples are pharmacokinetic modeling in DCE MRI/CT, ADC calculations and IVIM modeling in diffusion-weighted MRI and Z-spectra analysis in chemical exchange saturation transfer MRI. Most available software tools are limited to a special purpose and do not allow for own developments and extensions. Furthermore, they are mostly designed as stand-alone solutions using external frameworks and thus cannot be easily incorporated natively in the analysis workflow. We present a framework for medical image fitting tasks that is included in MITK, following a rigorous open-source, well-integrated and operating system independent policy. Software engineering-wise, the local models, the fitting infrastructure and the results representation are abstracted and thus can be easily adapted to any model fitting task on image data, independent of image modality or model. Several ready-to-use libraries for model fitting and use-cases, including fit evaluation and visualization, were implemented. Their embedding into MITK allows for easy data loading, pre- and post-processing and thus a natural inclusion of model fitting into an overarching workflow. As an example, we present a comprehensive set of plug-ins for the analysis of DCE MRI data, which we validated on existing and novel digital phantoms, yielding competitive deviations between fit and ground truth. Providing a very flexible environment, our software mainly addresses developers of medical imaging software that includes model fitting algorithms and tools. Additionally, the framework is of high interest to users in the domain of perfusion MRI, as it offers feature-rich, freely available, validated tools to perform pharmacokinetic analysis on DCE MRI data, with both interactive and automatized batch processing workflows.Comment: 31 pages, 11 figures URL: http://mitk.org/wiki/MITK-ModelFi

Identifying and Evaluating Change Patterns and Change Support Features in Process-Aware Information Systems.

In order to provide effective support, the introduction of process-aware information systems (PAIS) must not freeze existing business processes. Instead PAIS should allow authorized users to flexibly deviate from the predefined processes if required and to evolve business processes in a controlled manner over time. Many software vendors promise flexible system solutions for realizing such adaptive PAIS, but are often unable to cope with fundamental issues elated to process change (e.g., correctness and robustness). The existence of different process support paradigms and the lack of methods for comparing existing change approaches makes it difficult for PAIS engineers to choose the adequate technology. In this paper we suggest a set of changes patterns and change support features to foster systematic comparison of existing process management technology with respect to change support. Based on these change patterns and features, we provide a detailed analysis and evaluation of selected systems from both academia and industry

Change Support in Process-Aware Information Systems - A Pattern-Based Analysis

In today's dynamic business world the economic success of an enterprise increasingly depends on its ability to react to changes in its environment in a quick and flexible way. Process-aware information systems (PAIS) offer promising perspectives in this respect and are increasingly employed for operationally supporting business processes. To provide effective business process support, flexible PAIS are needed which do not freeze existing business processes, but allow for loosely specified processes, which can be detailed during run-time. In addition, PAIS should enable authorized users to flexibly deviate from the predefined processes if required (e.g., by allowing them to dynamically add, delete, or move process activities) and to evolve business processes over time. At the same time PAIS must ensure consistency and robustness. The emergence of different process support paradigms and the lack of methods for comparing existing change approaches have made it difficult for PAIS engineers to choose the adequate technology. In this paper we suggest a set of changes patterns and change support features to foster the systematic comparison of existing process management technology with respect to process change support. Based on these change patterns and features, we provide a detailed analysis and evaluation of selected systems from both academia and industry. The identified change patterns and change support features facilitate the comparison of change support frameworks, and consequently will support PAIS engineers in selecting the right technology for realizing flexible PAIS. In addition, this work can be used as a reference for implementing more flexible PAIS

Data in Business Process Models. A Preliminary Empirical Study

Traditional activity-centric process modeling languages treat data as simple black boxes acting as input or output for activities. Many alternate and emerging process modeling paradigms, such as case handling and artifact-centric process modeling, give data a more central role. This is achieved by introducing lifecycles and states for data objects, which is beneficial when modeling data-or knowledge-intensive processes. We assume that traditional activity-centric process modeling languages lack the capabilities to adequately capture the complexity of such processes. To verify this assumption we conducted an online interview among BPM experts. The results not only allow us to identify various profiles of persons modeling business processes, but also the problems that exist in contemporary modeling languages w.r.t. The modeling of business data. Overall, this preliminary empirical study confirms the necessity of data-awareness in process modeling notations in general