Computerized Analysis of Magnetic Resonance Images to Study Cerebral Anatomy in Developing Neonates

The study of cerebral anatomy in developing neonates is of great importance for the understanding of brain development during the early period of life. This dissertation therefore focuses on three challenges in the modelling of cerebral anatomy in neonates during brain development. The methods that have been developed all use Magnetic Resonance Images (MRI) as source data. To facilitate study of vascular development in the neonatal period, a set of image analysis algorithms are developed to automatically extract and model cerebral vessel trees. The whole process consists of cerebral vessel tracking from automatically placed seed points, vessel tree generation, and vasculature registration and matching. These algorithms have been tested on clinical Time-of- Flight (TOF) MR angiographic datasets. To facilitate study of the neonatal cortex a complete cerebral cortex segmentation and reconstruction pipeline has been developed. Segmentation of the neonatal cortex is not effectively done by existing algorithms designed for the adult brain because the contrast between grey and white matter is reversed. This causes pixels containing tissue mixtures to be incorrectly labelled by conventional methods. The neonatal cortical segmentation method that has been developed is based on a novel expectation-maximization (EM) method with explicit correction for mislabelled partial volume voxels. Based on the resulting cortical segmentation, an implicit surface evolution technique is adopted for the reconstruction of the cortex in neonates. The performance of the method is investigated by performing a detailed landmark study. To facilitate study of cortical development, a cortical surface registration algorithm for aligning the cortical surface is developed. The method first inflates extracted cortical surfaces and then performs a non-rigid surface registration using free-form deformations (FFDs) to remove residual alignment. Validation experiments using data labelled by an expert observer demonstrate that the method can capture local changes and follow the growth of specific sulcus

Efficient Acoustic Simulation for Immersive Media and Digital Fabrication

Sound is a crucial part of our life. Well-designed acoustic behaviors can lead to significant improvement in both physical and virtual interactions. In computer graphics, most existing methods focused primarily on improving the accuracy. It remained underexplored on how to develop efficient acoustic simulation algorithms for interactive practical applications. The challenges arise from the dilemma between expensive accurate simulations and fast feedback demanded by intuitive user interaction: traditional physics-based acoustic simulations are computationally expensive; yet, for end users to benefit from the simulations, it is crucial to give prompt feedback during interactions. In this thesis, I investigate how to develop efficient acoustic simulations for real-world applications such as immersive media and digital fabrication. To address the above-mentioned challenges, I leverage precomputation and optimization to significantly improve the speed while preserving the accuracy of complex acoustic phenomena. This work discusses three efforts along this research direction: First, to ease sound designer's workflow, we developed a fast keypoint-based precomputation algorithm to enable interactive acoustic transfer values in virtual sound simulations. Second, for realistic audio editing in 360° videos, we proposed an inverse material optimization based on fast sound simulation and a hybrid ambisonic audio synthesis that exploits the directional isotropy in spatial audios. Third, we devised a modular approach to efficiently simulate and optimize fabrication-ready acoustic filters, achieving orders of magnitudes speedup while maintaining the simulation accuracy. Through this series of projects, I demonstrate a wide range of applications made possible by efficient acoustic simulations