Efficient Two-Stage Group Testing Algorithms for Genetic Screening

Efficient two-stage group testing algorithms that are particularly suited for rapid and less-expensive DNA library screening and other large scale biological group testing efforts are investigated in this paper. The main focus is on novel combinatorial constructions in order to minimize the number of individual tests at the second stage of a two-stage disjunctive testing procedure. Building on recent work by Levenshtein (2003) and Tonchev (2008), several new infinite classes of such combinatorial designs are presented.Comment: 14 pages; to appear in "Algorithmica". Part of this work has been presented at the ICALP 2011 Group Testing Workshop; arXiv:1106.368

Optimal Partitioned Cyclic Difference Packings for Frequency Hopping and Code Synchronization

Optimal partitioned cyclic difference packings (PCDPs) are shown to give rise to optimal frequency-hopping sequences and optimal comma-free codes. New constructions for PCDPs, based on almost difference sets and cyclic difference matrices, are given. These produce new infinite families of optimal PCDPs (and hence optimal frequency-hopping sequences and optimal comma-free codes). The existence problem for optimal PCDPs in ${\mathbb Z}_{3m}$, with $m$ base blocks of size three, is also solved for all $m\not\equiv 8,16\pmod{24}$.Comment: to appear in IEEE Transactions on Information Theor

Hadamard partitioned difference families and their descendants

If $D$ is a $(4u^2,2u^2-u,u^2-u)$ Hadamard difference set (HDS) in $G$, then $\{G,G\setminus D\}$ is clearly a $(4u^2,[2u^2-u,2u^2+u],2u^2)$ partitioned difference family (PDF). Any $(v,K,\lambda)$-PDF will be said of Hadamard-type if $v=2\lambda$ as the one above. We present a doubling construction which, starting from any such PDF, leads to an infinite class of PDFs. As a special consequence, we get a PDF in a group of order $4u^2(2n+1)$ and three block-sizes $4u^2-2u$, $4u^2$ and $4u^2+2u$, whenever we have a $(4u^2,2u^2-u,u^2-u)$-HDS and the maximal prime power divisors of $2n+1$ are all greater than $4u^2+2u$