Improved Lower Bounds for Constant GC-Content DNA Codes

The design of large libraries of oligonucleotides having constant GC-content and satisfying Hamming distance constraints between oligonucleotides and their Watson-Crick complements is important in reducing hybridization errors in DNA computing, DNA microarray technologies, and molecular bar coding. Various techniques have been studied for the construction of such oligonucleotide libraries, ranging from algorithmic constructions via stochastic local search to theoretical constructions via coding theory. We introduce a new stochastic local search method which yields improvements up to more than one third of the benchmark lower bounds of Gaborit and King (2005) for n-mer oligonucleotide libraries when n <= 14. We also found several optimal libraries by computing maximum cliques on certain graphs.Comment: 4 page

Recent Advances in Graph Partitioning

We survey recent trends in practical algorithms for balanced graph partitioning together with applications and future research directions

Decision-making and strategic thinking through analogies

When faced with a complex scenario, how does understanding arise in one’s mind? How does one integrate disparate cues into a global, meaningful whole? Consider the chess game: how do humans avoid the combinatorial explosion? How are abstract ideas represented? The purpose of this paper is to propose a new computational model of human chess intuition and intelligence. We suggest that analogies and abstract roles are crucial to solving these landmark problems. We present a proof-of-concept model, in the form of a computational architecture, which may be able to account for many crucial aspects of human intuition, such as (i) concentration of attention to relevant aspects, (ii) \ud how humans may avoid the combinatorial explosion, (iii) perception of similarity at a strategic level, and (iv) a state of meaningful anticipation over how a global scenario \ud may evolve