Colorectal Cancer Classification using Deep Convolutional Networks - An Experimental Study

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Quantifying the effects of data augmentation and stain color normalization in convolutional neural networks for computational pathology

Stain variation is a phenomenon observed when distinct pathology laboratories stain tissue slides that exhibit similar but not identical color appearance. Due to this color shift between laboratories, convolutional neural networks (CNNs) trained with images from one lab often underperform on unseen images from the other lab. Several techniques have been proposed to reduce the generalization error, mainly grouped into two categories: stain color augmentation and stain color normalization. The former simulates a wide variety of realistic stain variations during training, producing stain-invariant CNNs. The latter aims to match training and test color distributions in order to reduce stain variation. For the first time, we compared some of these techniques and quantified their effect on CNN classification performance using a heterogeneous dataset of hematoxylin and eosin histopathology images from 4 organs and 9 pathology laboratories. Additionally, we propose a novel unsupervised method to perform stain color normalization using a neural network. Based on our experimental results, we provide practical guidelines on how to use stain color augmentation and stain color normalization in future computational pathology applications.Comment: Accepted in the Medical Image Analysis journa

Research on Rectal Tumor Identification Method by Convolutional Neural Network Based on Multi-Feature Fusion

Aiming at the obscure features of tumors in rectal CT images and their complexity, this paper proposes a multi-feature fusion-based convolutional neural network rectal tumor recognition method and uses it to model rectal tumors for classification experiments. This method extracts the convolutional features from rectal CT images using Alexnet, VGG16, ResNet, and DenseNet, respectively. At the same time, local features such as histogram of oriented gradient, local binary pattern, and HU moment invariants are extracted from this image. The above local features are fused linearly with the convolutional features. Then we put the new fused features into the fully connected layer for image classification. The experimental results finally reached the accuracy rates of 92.6 %, 93.1 %, 91.7 %, and 91.1 %, respectively. Comparative experiments show that this method improves the accuracy of rectal tumor recognition

Deep Functional Mapping For Predicting Cancer Outcome

The effective understanding of the biological behavior and prognosis of cancer subtypes is becoming very important in-patient administration. Cancer is a diverse disorder in which a significant medical progression and diagnosis for each subtype can be observed and characterized. Computer-aided diagnosis for early detection and diagnosis of many kinds of diseases has evolved in the last decade. In this research, we address challenges associated with multi-organ disease diagnosis and recommend numerous models for enhanced analysis. We concentrate on evaluating the Magnetic Resonance Imaging (MRI), Computed Tomography (CT), and Positron Emission Tomography (PET) for brain, lung, and breast scans to detect, segment, and classify types of cancer from biomedical images. Moreover, histopathological, and genomic classification of cancer prognosis has been considered for multi-organ disease diagnosis and biomarker recommendation. We considered multi-modal, multi-class classification during this study. We are proposing implementing deep learning techniques based on Convolutional Neural Network and Generative Adversarial Network. In our proposed research we plan to demonstrate ways to increase the performance of the disease diagnosis by focusing on a combined diagnosis of histology, image processing, and genomics. It has been observed that the combination of medical imaging and gene expression can effectively handle the cancer detection situation with a higher diagnostic rate rather than considering the individual disease diagnosis. This research puts forward a blockchain-based system that facilitates interpretations and enhancements pertaining to automated biomedical systems. In this scheme, a secured sharing of the biomedical images and gene expression has been established. To maintain the secured sharing of the biomedical contents in a distributed system or among the hospitals, a blockchain-based algorithm is considered that generates a secure sequence to identity a hash key. This adaptive feature enables the algorithm to use multiple data types and combines various biomedical images and text records. All data related to patients, including identity, pathological records are encrypted using private key cryptography based on blockchain architecture to maintain data privacy and secure sharing of the biomedical contents

Decomposition of color wavelet with higher order statistical texture and convolutional neural network features set based classification of colorectal polyps from video endoscopy

Gastrointestinal cancer is one of the leading causes of death across the world. The gastrointestinal polyps are considered as the precursors of developing this malignant cancer. In order to condense the probability of cancer, early detection and removal of colorectal polyps can be cogitated. The most used diagnostic modality for colorectal polyps is video endoscopy. But the accuracy of diagnosis mostly depends on doctors' experience that is crucial to detect polyps in many cases. Computer-aided polyp detection is promising to reduce the miss detection rate of the polyp and thus improve the accuracy of diagnosis results. The proposed method first detects polyp and non-polyp then illustrates an automatic polyp classification technique from endoscopic video through color wavelet with higher-order statistical texture feature and Convolutional Neural Network (CNN). Gray Level Run Length Matrix (GLRLM) is used for higher-order statistical texture features of different directions (Ɵ = 0o, 45o, 90o, 135o). The features are fed into a linear support vector machine (SVM) to train the classifier. The experimental result demonstrates that the proposed approach is auspicious and operative with residual network architecture, which triumphs the best performance of accuracy, sensitivity, and specificity of 98.83%, 97.87%, and 99.13% respectively for classification of colorectal polyps on standard public endoscopic video databases