Gray’s revised Reinforcement Sensitivity Theory in relation to Attention-Deficit/Hyperactivity and Tourette-like behaviors in the general population

Attention-Deficit/Hyperactivity Disorder (ADHD) and Tourette Syndrome (TS) present as distinct conditions clinically; however, they show comorbidity and inhibitory control deficits have been proposed to underlie both. The role of reinforcement sensitivity in ADHD has been studied previously, but no study has addressed this in relation to TS-like behaviors in the general population. The present study examined these associations within the remit of the revised Reinforcement Sensitivity Theory (rRST). One hundred and thirty-eight participants completed psychometric measures of the rRST, and self-report checklists for ADHD- and TS-like behaviors

Representations of sources and data: working with exceptions to hierarchy in historical documents

No abstract available

Genome-Wide Studies of Histone Demethylation Catalysed by the Fission Yeast Homologues of Mammalian LSD1

In order to gain a more global view of the activity of histone demethylases, we report here genome-wide studies of the fission yeast SWIRM and polyamine oxidase (PAO) domain homologues of mammalian LSD1. Consistent with previous work we find that the two S. pombe proteins, which we name Swm1 and Swm2 (after SWIRM1 and SWIRM2), associate together in a complex. However, we find that this complex specifically demethylates lysine 9 in histone H3 (H3K9) and both up- and down-regulates expression of different groups of genes. Using chromatin-immunoprecipitation, to isolate fragments of chromatin containing either H3K4me2 or H3K9me2, and DNA microarray analysis (ChIP-chip), we have studied genome-wide changes in patterns of histone methylation, and their correlation with gene expression, upon deletion of the swm1+ gene. Using hyper-geometric probability comparisons we uncover genetic links between lysine-specific demethylases, the histone deacetylase Clr6, and the chromatin remodeller Hrp1. The data presented here demonstrate that in fission yeast the SWIRM/PAO domain proteins Swm1 and Swm2 are associated in complexes that can remove methyl groups from lysine 9 methylated histone H3. In vitro, we show that bacterially expressed Swm1 also possesses lysine 9 demethylase activity. In vivo, loss of Swm1 increases the global levels of both H3K9me2 and H3K4me2. A significant accumulation of H3K4me2 is observed at genes that are up-regulated in a swm1 deletion strain. In addition, H3K9me2 accumulates at some genes known to be direct Swm1/2 targets that are down-regulated in the swm1¿ strain. The in vivo data indicate that Swm1 acts in concert with the HDAC Clr6 and the chromatin remodeller Hrp1 to repress gene expression. In addition, our in vitro analyses suggest that the H3K9 demethylase activity requires an unidentified post-translational modification to allow it to act. Thus, our results highlight complex interactions between histone demethylase, deacetylase and chromatin remodelling activities in the regulation of gene expression

Short range correlations in relativistic nuclear matter models

Short range correlations are introduced using unitary correlation method in a relativistic approach to the equation of state of the infinite nuclear matter in the framework of the Hartree-Fock approximation. It is shown that the correlations give rise to an extra node in the ground-state wave-function in the nucleons, contrary to what happens in non-relativistic calculations with a hard core. The effect of the correlations in the ground state properties of the nuclear matter and neutron matter is studied. The nucleon effective mass and equation of state (EOS) are very sensitive to short range correlations. In particular, if the pion contact term is neglected a softening of the EOS is predicted. Correlations have also an important effect on the neutron matter EOS which presents no binding but only a very shallow minimum contrary to the Walecka model.Comment: 8pages, 4 figure

The Calibration of Mid-Infrared Star Formation Rate Indicators

With the goal of investigating the degree to which the mid-infrared emission traces the star formation rate (SFR), we analyze Spitzer 8 um and 24 um data of star-forming regions in a sample of 33 nearby galaxies with available HST/NICMOS images in the Paschen-alpha (1.8756 um) emission line. The galaxies are drawn from the Spitzer Infrared Nearby Galaxies Survey (SINGS) sample, and cover a range of morphologies and a factor ~10 in oxygen abundance. Published data on local low-metallicity starburst galaxies and Luminous Infrared Galaxies are also included in the analysis. Both the stellar-continuum-subtracted 8 um emission and the 24 um emission correlate with the extinction-corrected Pa-alpha line emission, although neither relationship is linear. Simple models of stellar populations and dust extinction and emission are able to reproduce the observed non-linear trend of the 24 um emission versus number of ionizing photons, including the modest deficiency of 24 um emission in the low metallicity regions, which results from a combination of decreasing dust opacity and dust temperature at low luminosities. Conversely, the trend of the 8 um emission as a function of the number of ionizing photons is not well reproduced by the same models. The 8 um emission is contributed, in larger measure than the 24 um emission, by dust heated by non-ionizing stellar populations, in agreement with previous findings. Two SFR calibrations, one using the 24 um emission and the other using a combination of the 24 um and H-alpha luminosities (Kennicutt et al. 2007), are presented. No calibration is presented for the 8 um emission, because of its significant dependence on both metallicity and environment. The calibrations presented here should be directly applicable to systems dominated by on-going star formation.Comment: 67 pages, 15 figures, accepted for publication on the Astrophysical Journal; replacement contains: correction to equation 8; important tweaks to equation 9; various typos correcte

A Scalable Byzantine Grid

Modern networks assemble an ever growing number of nodes. However, it remains difficult to increase the number of channels per node, thus the maximal degree of the network may be bounded. This is typically the case in grid topology networks, where each node has at most four neighbors. In this paper, we address the following issue: if each node is likely to fail in an unpredictable manner, how can we preserve some global reliability guarantees when the number of nodes keeps increasing unboundedly ? To be more specific, we consider the problem or reliably broadcasting information on an asynchronous grid in the presence of Byzantine failures -- that is, some nodes may have an arbitrary and potentially malicious behavior. Our requirement is that a constant fraction of correct nodes remain able to achieve reliable communication. Existing solutions can only tolerate a fixed number of Byzantine failures if they adopt a worst-case placement scheme. Besides, if we assume a constant Byzantine ratio (each node has the same probability to be Byzantine), the probability to have a fatal placement approaches 1 when the number of nodes increases, and reliability guarantees collapse. In this paper, we propose the first broadcast protocol that overcomes these difficulties. First, the number of Byzantine failures that can be tolerated (if they adopt the worst-case placement) now increases with the number of nodes. Second, we are able to tolerate a constant Byzantine ratio, however large the grid may be. In other words, the grid becomes scalable. This result has important security applications in ultra-large networks, where each node has a given probability to misbehave.Comment: 17 page

Risk as reward: Reinforcement sensitivity theory and psychopathic personality perspectives on everyday risk-taking

This study updates and synthesises research on the extent to which impulsive and antisocial disposition predicts everyday pro- and antisocial risk-taking behaviour. We use the Reinforcement Sensitivity Theory (RST) of personality to measure approach, avoidance, and inhibition dispositions, as well as measures of Callous-Unemotional and psychopathic personalities. In an international sample of 454 respondents, results showed that RST, psychopathic personality, and callous-unemotional measures accounted for different aspects of risk-taking behaviour. Specifically, traits associated with ‘fearlessness’ related more to ‘prosocial’ (recreational and social) risk-taking, whilst traits associated with ‘impulsivity’ related more to ‘antisocial’ (ethical and health) risk-taking. Further, we demonstrate that psychopathic personality may be demonstrated by combining the RST and callous-unemotional traits (high impulsivity, callousness, and low fear). Overall this study showed how impulsive, fearless and antisocial traits can be used in combination to identify pro- and anti-social risk-taking behaviours; suggestions for future research are indicated

Theory of the 2S-2P Lamb shift and 2S hyperfine splitting in muonic hydrogen

The 7 standard deviations between the proton rms charge radius from muonic hydrogen and the CODATA-10 value from hydrogen spectroscopy and electron-scattering has caused considerable discussions. Here, we review the theory of the 2S-2P Lamb shift and 2S hyperfine splitting in muonic hydrogen combining the published contributions and theoretical approaches. The prediction of these quantities is necessary for the determination of both proton charge and Zemach radii from the two 2S-2P transition frequencies measured in muonic hydrogen.Comment: 20 pages with 3 Tables summarising the contributions to the muonic hydrogen Lamb shift and hyperfine splittin