The coming decade of digital brain research - A vision for neuroscience at the intersection of technology and computing

Brain research has in recent years indisputably entered a new epoch, driven by substantial methodological advances and digitally enabled data integration and modeling at multiple scales – from molecules to the whole system. Major advances are emerging at the intersection of neuroscience with technology and computing. This new science of the brain integrates high-quality basic research, systematic data integration across multiple scales, a new culture of large-scale collaboration and translation into applications. A systematic approach, as pioneered in Europe’s Human Brain Project (HBP), will be essential in meeting the pressing medical and technological challenges of the coming decade. The aims of this paper are: To develop a concept for the coming decade of digital brain research To discuss it with the research community at large, with the aim of identifying points of convergence and common goals. To provide a scientific framework for current and future development of EBRAINS. To inform and engage stakeholders, funding organizations and research institutions regarding future digital brain research. To identify and address key ethical and societal issues. While we do not claim that there is a ‘one size fits all’ approach to addressing these aspects, we are convinced that discussions around the theme of digital brain research will help drive progress in the broader field of neuroscience

Brain simulation as a cloud service: The Virtual Brain on EBRAINS

The Virtual Brain (TVB) is now available as open-source services on the cloud research platform EBRAINS (ebrains.eu). It offers software for constructing, simulating and analysing brain network models including the TVB simulator; magnetic resonance imaging (MRI) processing pipelines to extract structural and functional brain networks; combined simulation of large-scale brain networks with small-scale spiking networks; automatic conversion of user-specified model equations into fast simulation code; simulation-ready brain models of patients and healthy volunteers; Bayesian parameter optimization in epilepsy patient models; data and software for mouse brain simulation; and extensive educational material. TVB cloud services facilitate reproducible online collaboration and discovery of data assets, models, and software embedded in scalable and secure workflows, a precondition for research on large cohort data sets, better generalizability, and clinical translation

Brain simulation as a cloud service: The Virtual Brain on EBRAINS

open access articleThe Virtual Brain (TVB) is now available as open-source services on the cloud research platform EBRAINS (ebrains.eu). It offers software for constructing, simulating and analysing brain network models including the TVB simulator; magnetic resonance imaging (MRI) processing pipelines to extract structural and functional brain networks; combined simulation of large-scale brain networks with small-scale spiking networks; automatic con- version of user-specified model equations into fast simulation code; simulation-ready brain models of patients and healthy volunteers; Bayesian parameter optimization in epilepsy patient models; data and software for mouse brain simulation; and extensive educational material. TVB cloud services facilitate reproducible online collabo- ration and discovery of data assets, models, and software embedded in scalable and secure workflows, a precondition for research on large cohort data sets, better generalizability, and clinical translation

The effect of roles on computer-supported collaborative learning.

Strijbos, J. W. (2004). The effect of roles on computer-supported collaborative learning. Unpublished doctoral dissertation, Open University of the Netherlands, The Netherlands

Control Architecture Modeling for Future Power Systems

Uncontrollable power generation, distributed energy resources, controllable demand, etc. are fundamental aspects of energy systems largely based on renewable energy supply. These technologies have in common that they contradict the conventional categories of electric power system operation. As their introduction has proceeded incrementally in the past, operation strategies of the power system could be adapted. For example much more wind power could be integrated than originally anticipated, largely due to the flexibility reserves already present in the power system, and the possibility of interregional electricity exchange. However, at the same time, it seems that the overall system design cannot keep up by simply adapting in response to changes, but that also new strategies have to be designed in anticipation. Changes to the electricity markets have been suggested to adapt to the limited predictability of wind power, and several new control strategies have been proposed, in particular to enable the control of distributed energy resources, including for example, distributed generation or electric vehicles. Market designs addressing the procurement of balancing resources are highly dependent on the operation strategies specifying the resource requirements. How should one decide which control strategy and market configuration is best for a future power system? Most research up to this point has addressed single isolated aspects of this design problem. Those of the ideas that fit with current markets and operation concepts are lucky; they can be evaluated on the present design. But how could they be evaluated on a potential future power system? Approaches are required that support the design and evaluation of power system operation and control in context of future energy scenarios. This work addresses this challenge, not by providing a universal solution, but by providing basic modeling methodology that enables better problem formulation and by suggesting an approach to addressing the general chicken/egg problem of planning and re-design of system operation and control. The dissertation first focuses on the development of models, diagrams, that support the conceptual design of control and operation strategies, where a central theme is the focus on modeling system goals and functions rather than system structure. The perspective is then shifted toward long-term energy scenarios and adaptation of power system operation, considering the integration of energy scenario models with the re-design of operation strategies. The main contributions in the first part are, firstly, by adaptation of an existing functional modeling approach called Multilevel Flow Modeling (MFM) to the power systems domain, identifying the means-ends composition of control levels and development of principles for the consistent modeling of control structures, a formalization of control-as-a-service; secondly, the formal mapping of fluctuating and controllable resources to a multi-scale and multi-stage representation of control and operation structures; and finally the application to some concrete study cases, including a present system balancing, and proposed control structures such as Microgrids and Cells. In the second part, the main contributions are the outline of a formation strategy, integrating the design and model-based evaluation of future power system operation concepts with iterative energy scenario development. Finally, a new modeling framework for development and evaluation of power system operation in context of energy-storage based power system balancing is introduced.<br/

Emerging Converter Topologies and Control for Grid Connected Photovoltaic Systems

Continuous cost reduction of photovoltaic (PV) systems and the rise of power auctions resulted in the establishment of PV power not only as a green energy source but also as a cost-effective solution to the electricity generation market. Various commercial solutions for grid-connected PV systems are available at any power level, ranging from multi-megawatt utility-scale solar farms to sub-kilowatt residential PV installations. Compared to utility-scale systems, the feasibility of small-scale residential PV installations is still limited by existing technologies that have not yet properly address issues like operation in weak grids, opaque and partial shading, etc. New market drivers such as warranty improvement to match the PV module lifespan, operation voltage range extension for application flexibility, and embedded energy storage for load shifting have again put small-scale PV systems in the spotlight. This Special Issue collects the latest developments in the field of power electronic converter topologies, control, design, and optimization for better energy yield, power conversion efficiency, reliability, and longer lifetime of the small-scale PV systems. This Special Issue will serve as a reference and update for academics, researchers, and practicing engineers to inspire new research and developments that pave the way for next-generation PV systems for residential and small commercial applications

High-Performance Modelling and Simulation for Big Data Applications

This open access book was prepared as a Final Publication of the COST Action IC1406 “High-Performance Modelling and Simulation for Big Data Applications (cHiPSet)“ project. Long considered important pillars of the scientific method, Modelling and Simulation have evolved from traditional discrete numerical methods to complex data-intensive continuous analytical optimisations. Resolution, scale, and accuracy have become essential to predict and analyse natural and complex systems in science and engineering. When their level of abstraction raises to have a better discernment of the domain at hand, their representation gets increasingly demanding for computational and data resources. On the other hand, High Performance Computing typically entails the effective use of parallel and distributed processing units coupled with efficient storage, communication and visualisation systems to underpin complex data-intensive applications in distinct scientific and technical domains. It is then arguably required to have a seamless interaction of High Performance Computing with Modelling and Simulation in order to store, compute, analyse, and visualise large data sets in science and engineering. Funded by the European Commission, cHiPSet has provided a dynamic trans-European forum for their members and distinguished guests to openly discuss novel perspectives and topics of interests for these two communities. This cHiPSet compendium presents a set of selected case studies related to healthcare, biological data, computational advertising, multimedia, finance, bioinformatics, and telecommunications