7,922 research outputs found
The Small World of Osteocytes: Connectomics of the Lacuno-Canalicular Network in Bone
Osteocytes and their cell processes reside in a large, interconnected network
of voids pervading the mineralized bone matrix of most vertebrates. This
osteocyte lacuno-canalicular network (OLCN) is believed to play important roles
in mechanosensing, mineral homeostasis, and for the mechanical properties of
bone. While the extracellular matrix structure of bone is extensively studied
on ultrastructural and macroscopic scales, there is a lack of quantitative
knowledge on how the cellular network is organized. Using a recently introduced
imaging and quantification approach, we analyze the OLCN in different bone
types from mouse and sheep that exhibit different degrees of structural
organization not only of the cell network but also of the fibrous matrix
deposited by the cells. We define a number of robust, quantitative measures
that are derived from the theory of complex networks. These measures enable us
to gain insights into how efficient the network is organized with regard to
intercellular transport and communication. Our analysis shows that the cell
network in regularly organized, slow-growing bone tissue from sheep is less
connected, but more efficiently organized compared to irregular and
fast-growing bone tissue from mice. On the level of statistical topological
properties (edges per node, edge length and degree distribution), both network
types are indistinguishable, highlighting that despite pronounced differences
at the tissue level, the topological architecture of the osteocyte canalicular
network at the subcellular level may be independent of species and bone type.
Our results suggest a universal mechanism underlying the self-organization of
individual cells into a large, interconnected network during bone formation and
mineralization
3次元アトムプローブ法を用いたシリコンデバイス中の不純物分布のナノスケール分析
Tohoku University永井康介課
Biomedical Signal and Image Processing
Written for senior-level and first year graduate students in biomedical signal and image processing, this book describes fundamental signal and image processing techniques that are used to process biomedical information. The book also discusses application of these techniques in the processing of some of the main biomedical signals and images, such as EEG, ECG, MRI, and CT. New features of this edition include the technical updating of each chapter along with the addition of many more examples, the majority of which are MATLAB based
Revealing atomic-scale vacancy-solute interaction in nickel
Imaging individual vacancies in solids and revealing their interactions with
solute atoms remains one of the frontiers in microscopy and microanalysis. Here
we study a creep-deformed binary Ni-2 at.% Ta alloy. Atom probe tomography
reveals a random distribution of Ta. Field ion microscopy, with contrast
interpretation supported by density-functional theory and time-of-flight mass
spectrometry, evidences a positive correlation of tantalum with vacancies. Our
results support solute-vacancy binding, which explains improvement in creep
resistance of Ta-containing Ni-based superalloys and helps guide future
material design strategies.Comment: Submitted to Physics Review Lette
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Imaging of a fluid injection process using geophysical data - A didactic example
In many subsurface industrial applications, fluids are injected into or withdrawn from a geologic formation. It is of practical interest to quantify precisely where, when, and by how much the injected fluid alters the state of the subsurface. Routine geophysical monitoring of such processes attempts to image the way that geophysical properties, such as seismic velocities or electrical conductivity, change through time and space and to then make qualitative inferences as to where the injected fluid has migrated. The more rigorous formulation of the time-lapse geophysical inverse problem forecasts how the subsurface evolves during the course of a fluid-injection application. Using time-lapse geophysical signals as the data to be matched, the model unknowns to be estimated are the multiphysics forward-modeling parameters controlling the fluid-injection process. Properly reproducing the geophysical signature of the flow process, subsequent simulations can predict the fluid migration and alteration in the subsurface. The dynamic nature of fluid-injection processes renders imaging problems more complex than conventional geophysical imaging for static targets. This work intents to clarify the related hydrogeophysical parameter estimation concepts
Complex networks in brain electrical activity
We analyze the complex networks associated with brain electrical activity.
Multichannel EEG measurements are first processed to obtain 3D voxel
activations using the tomographic algorithm LORETA. Then, the correlation of
the current intensity activation between voxel pairs is computed to produce a
voxel cross-correlation coefficient matrix. Using several correlation
thresholds, the cross-correlation matrix is then transformed into a network
connectivity matrix and analyzed. To study a specific example, we selected data
from an earlier experiment focusing on the MMN brain wave. The resulting
analysis highlights significant differences between the spatial activations
associated with Standard and Deviant tones, with interesting physiological
implications. When compared to random data networks, physiological networks are
more connected, with longer links and shorter path lengths. Furthermore, as
compared to the Deviant case, Standard data networks are more connected, with
longer links and shorter path lengths--i.e., with a stronger ``small worlds''
character. The comparison between both networks shows that areas known to be
activated in the MMN wave are connected. In particular, the analysis supports
the idea that supra-temporal and inferior frontal data work together in the
processing of the differences between sounds by highlighting an increased
connectivity in the response to a novel sound.Comment: 22 pages, 5 figures. Starlab preprint. This version is an attempt to
include better figures (no content change
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