Towards population coding principles in the primate premotor and parietal grasping network

As humans, the only way for us to interact with the world around us is by utilizing our highly trained motor system. Therefore, understanding how the brain generates movement is essential to understanding all aspects of human behavior. Despite the importance the motor system, the manner in which the brain prepares and executes movements, especially grasping movements, is still unclear. In this thesis I undertake a number of electrophysiological and computational experiments on macaque monkeys, primates showing similar grasping behavior to humans, to shed light on how grasping movements are planned and executed across distributed brain regions in both parietal and premotor cortices. Through these experiments, I reveal how the use of large-scale electrophysiological recording of hundreds of neurons simultaneously in primates allows the investigation of network computational principles essential for grasping, and I develop a series of analytical techniques for dissecting the large data sets collected from these experiments. In chapter 2.1 I show how large-scale parallel recordings can be leveraged to make behavioral predictions on single trials. The methods used to extract single-trial predictions varied in their performance, but population-based methods provided the most consistent and meaningful interpretation of the data. In addition, the success of these behavioral predictions could be used to make inferences about how areas differ in their contribution to preparation of grasping movements. It was found that while reaction time could be predicted from the population activity of either area, performance was significantly higher using the data from premotor cortex, suggesting that population activity in premotor cortex may have a more direct effect on behavior. In chapter 2.2 I show how preparation and movement intermingle and interact with one another on the continuum between immediate and withheld movement. Our population-based and dimensionality reduction techniques enable interpretation of the data, even when single neuron tuning properties are highly temporally and functionally complex. Activity in parietal cortex stabilizes during the memory period, while it continues to evolve in premotor cortex, revealing a decodable signature of time. Furthermore, activity during movement initiation clusters into two groups, movements initiated as fast as possible and movements from memory, showing how a state shift likely occurs on the border between these two types of actions. In chapter 2.3 I show that the question of how motor cortex controls movement is an ongoing issue in the field. I address crucial details about recent methodology used to extract rotational dynamics in motor cortex. I show how a simple neural network simulation and novel statistical test reveal properties of motor cortex not examined before, showing how models of movement generation can be essential tools in adding perspective to empirical results. Finally, in chapter 2.4 I show how the specificity of hand use can be used as a tool to dissociate levels of abstraction in the visual to motor transformation in parietal and premotor cortex. While preparatory activity is mostly hand-invariant in parietal cortex, activity in premotor cortex dissociates the intended hand use well before movement. Importantly, we show how appropriate dimensionality reduction techniques can disentangle the effects of multiple task parameters and find latent dimensions consistent between areas and animals. Together, the results of my experiments reinforce the importance of seeing the motor system not as a collection of individually tuned neurons, but as a dynamic network of neurons continuously acting together to produce the complex and flexible behavior we observe in all primates

Statistical and Dynamical Modeling of Riemannian Trajectories with Application to Human Movement Analysis

abstract: The data explosion in the past decade is in part due to the widespread use of rich sensors that measure various physical phenomenon -- gyroscopes that measure orientation in phones and fitness devices, the Microsoft Kinect which measures depth information, etc. A typical application requires inferring the underlying physical phenomenon from data, which is done using machine learning. A fundamental assumption in training models is that the data is Euclidean, i.e. the metric is the standard Euclidean distance governed by the L-2 norm. However in many cases this assumption is violated, when the data lies on non Euclidean spaces such as Riemannian manifolds. While the underlying geometry accounts for the non-linearity, accurate analysis of human activity also requires temporal information to be taken into account. Human movement has a natural interpretation as a trajectory on the underlying feature manifold, as it evolves smoothly in time. A commonly occurring theme in many emerging problems is the need to \emph{represent, compare, and manipulate} such trajectories in a manner that respects the geometric constraints. This dissertation is a comprehensive treatise on modeling Riemannian trajectories to understand and exploit their statistical and dynamical properties. Such properties allow us to formulate novel representations for Riemannian trajectories. For example, the physical constraints on human movement are rarely considered, which results in an unnecessarily large space of features, making search, classification and other applications more complicated. Exploiting statistical properties can help us understand the \emph{true} space of such trajectories. In applications such as stroke rehabilitation where there is a need to differentiate between very similar kinds of movement, dynamical properties can be much more effective. In this regard, we propose a generalization to the Lyapunov exponent to Riemannian manifolds and show its effectiveness for human activity analysis. The theory developed in this thesis naturally leads to several benefits in areas such as data mining, compression, dimensionality reduction, classification, and regression.Dissertation/ThesisDoctoral Dissertation Electrical Engineering 201

Acoustic Approaches to Gender and Accent Identification

There has been considerable research on the problems of speaker and language recognition from samples of speech. A less researched problem is that of accent recognition. Although this is a similar problem to language identification, di�erent accents of a language exhibit more fine-grained di�erences between classes than languages. This presents a tougher problem for traditional classification techniques. In this thesis, we propose and evaluate a number of techniques for gender and accent classification. These techniques are novel modifications and extensions to state of the art algorithms, and they result in enhanced performance on gender and accent recognition. The first part of the thesis focuses on the problem of gender identification, and presents a technique that gives improved performance in situations where training and test conditions are mismatched. The bulk of this thesis is concerned with the application of the i-Vector technique to accent identification, which is the most successful approach to acoustic classification to have emerged in recent years. We show that it is possible to achieve high accuracy accent identification without reliance on transcriptions and without utilising phoneme recognition algorithms. The thesis describes various stages in the development of i-Vector based accent classification that improve the standard approaches usually applied for speaker or language identification, which are insu�cient. We demonstrate that very good accent identification performance is possible with acoustic methods by considering di�erent i-Vector projections, frontend parameters, i-Vector configuration parameters, and an optimised fusion of the resulting i-Vector classifiers we can obtain from the same data. We claim to have achieved the best accent identification performance on the test corpus for acoustic methods, with up to 90% identification rate. This performance is even better than previously reported acoustic-phonotactic based systems on the same corpus, and is very close to performance obtained via transcription based accent identification. Finally, we demonstrate that the utilization of our techniques for speech recognition purposes leads to considerably lower word error rates. Keywords: Accent Identification, Gender Identification, Speaker Identification, Gaussian Mixture Model, Support Vector Machine, i-Vector, Factor Analysis, Feature Extraction, British English, Prosody, Speech Recognition

Learning disentangled speech representations

A variety of informational factors are contained within the speech signal and a single short recording of speech reveals much more than the spoken words. The best method to extract and represent informational factors from the speech signal ultimately depends on which informational factors are desired and how they will be used. In addition, sometimes methods will capture more than one informational factor at the same time such as speaker identity, spoken content, and speaker prosody. The goal of this dissertation is to explore different ways to deconstruct the speech signal into abstract representations that can be learned and later reused in various speech technology tasks. This task of deconstructing, also known as disentanglement, is a form of distributed representation learning. As a general approach to disentanglement, there are some guiding principles that elaborate what a learned representation should contain as well as how it should function. In particular, learned representations should contain all of the requisite information in a more compact manner, be interpretable, remove nuisance factors of irrelevant information, be useful in downstream tasks, and independent of the task at hand. The learned representations should also be able to answer counter-factual questions. In some cases, learned speech representations can be re-assembled in different ways according to the requirements of downstream applications. For example, in a voice conversion task, the speech content is retained while the speaker identity is changed. And in a content-privacy task, some targeted content may be concealed without affecting how surrounding words sound. While there is no single-best method to disentangle all types of factors, some end-to-end approaches demonstrate a promising degree of generalization to diverse speech tasks. This thesis explores a variety of use-cases for disentangled representations including phone recognition, speaker diarization, linguistic code-switching, voice conversion, and content-based privacy masking. Speech representations can also be utilised for automatically assessing the quality and authenticity of speech, such as automatic MOS ratings or detecting deep fakes. The meaning of the term "disentanglement" is not well defined in previous work, and it has acquired several meanings depending on the domain (e.g. image vs. speech). Sometimes the term "disentanglement" is used interchangeably with the term "factorization". This thesis proposes that disentanglement of speech is distinct, and offers a viewpoint of disentanglement that can be considered both theoretically and practically

Interactive game for the training of portuguese vowels

Tese de mestrado integrado. Engenharia Electrotécnica e de Computadores. Faculdade de Engenharia. Universidade do Porto. 200

Making music through real-time voice timbre analysis: machine learning and timbral control

PhDPeople can achieve rich musical expression through vocal sound { see for example human beatboxing, which achieves a wide timbral variety through a range of extended techniques. Yet the vocal modality is under-exploited as a controller for music systems. If we can analyse a vocal performance suitably in real time, then this information could be used to create voice-based interfaces with the potential for intuitive and ful lling levels of expressive control. Conversely, many modern techniques for music synthesis do not imply any particular interface. Should a given parameter be controlled via a MIDI keyboard, or a slider/fader, or a rotary dial? Automatic vocal analysis could provide a fruitful basis for expressive interfaces to such electronic musical instruments. The principal questions in applying vocal-based control are how to extract musically meaningful information from the voice signal in real time, and how to convert that information suitably into control data. In this thesis we address these questions, with a focus on timbral control, and in particular we develop approaches that can be used with a wide variety of musical instruments by applying machine learning techniques to automatically derive the mappings between expressive audio input and control output. The vocal audio signal is construed to include a broad range of expression, in particular encompassing the extended techniques used in human beatboxing. The central contribution of this work is the application of supervised and unsupervised machine learning techniques to automatically map vocal timbre to synthesiser timbre and controls. Component contributions include a delayed decision-making strategy for low-latency sound classi cation, a regression-tree method to learn associations between regions of two unlabelled datasets, a fast estimator of multidimensional di erential entropy and a qualitative method for evaluating musical interfaces based on discourse analysis