2,360 research outputs found
SMART: Unique splitting-while-merging framework for gene clustering
Copyright @ 2014 Fa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted
use, distribution, and reproduction in any medium, provided the original author and source are credited.Successful clustering algorithms are highly dependent on parameter settings. The clustering performance degrades significantly unless parameters are properly set, and yet, it is difficult to set these parameters a priori. To address this issue, in this paper, we propose a unique splitting-while-merging clustering framework, named “splitting merging awareness tactics” (SMART), which does not require any a priori knowledge of either the number of clusters or even the possible range of this number. Unlike existing self-splitting algorithms, which over-cluster the dataset to a large number of clusters and then merge some similar clusters, our framework has the ability to split and merge clusters automatically during the process and produces the the most reliable clustering results, by intrinsically integrating many clustering techniques and tasks. The SMART framework is implemented with two distinct clustering paradigms in two algorithms: competitive learning and finite mixture model. Nevertheless, within the proposed SMART framework, many other algorithms can be derived for different clustering paradigms. The minimum message length algorithm is integrated into the framework as the clustering selection criterion. The usefulness of the SMART framework and its algorithms is tested in demonstration datasets and simulated gene expression datasets. Moreover, two real microarray gene expression datasets are studied using this approach. Based on the performance of many metrics, all numerical results show that SMART is superior to compared existing self-splitting algorithms and traditional algorithms. Three main properties of the proposed SMART framework are summarized as: (1) needing no parameters dependent on the respective dataset or a priori knowledge about the datasets, (2) extendible to many different applications, (3) offering superior performance compared with counterpart algorithms.National Institute for Health Researc
Clustering analysis for gene expression data: a methodological review
Clustering is one of most useful tools for the microarray gene expression data analysis. Although there have been many reviews and surveys in the literature, many good and effective clustering ideas have not been collected in a systematic way for some reasons. In this paper, we review five clustering families representing five clustering concepts rather than five algorithms. We also review some clustering validations and collect a list of benchmark gene expression datasets
Solution Path Clustering with Adaptive Concave Penalty
Fast accumulation of large amounts of complex data has created a need for
more sophisticated statistical methodologies to discover interesting patterns
and better extract information from these data. The large scale of the data
often results in challenging high-dimensional estimation problems where only a
minority of the data shows specific grouping patterns. To address these
emerging challenges, we develop a new clustering methodology that introduces
the idea of a regularization path into unsupervised learning. A regularization
path for a clustering problem is created by varying the degree of sparsity
constraint that is imposed on the differences between objects via the minimax
concave penalty with adaptive tuning parameters. Instead of providing a single
solution represented by a cluster assignment for each object, the method
produces a short sequence of solutions that determines not only the cluster
assignment but also a corresponding number of clusters for each solution. The
optimization of the penalized loss function is carried out through an MM
algorithm with block coordinate descent. The advantages of this clustering
algorithm compared to other existing methods are as follows: it does not
require the input of the number of clusters; it is capable of simultaneously
separating irrelevant or noisy observations that show no grouping pattern,
which can greatly improve data interpretation; it is a general methodology that
can be applied to many clustering problems. We test this method on various
simulated datasets and on gene expression data, where it shows better or
competitive performance compared against several clustering methods.Comment: 36 page
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A niching memetic algorithm for simultaneous clustering and feature selection
Clustering is inherently a difficult task, and is made even more difficult when the selection of relevant features is also an issue. In this paper we propose an approach for simultaneous clustering and feature selection using a niching memetic algorithm. Our approach (which we call NMA_CFS) makes feature selection an integral part of the global clustering search procedure and attempts to overcome the problem of identifying less promising locally optimal solutions in both clustering and feature selection, without making any a priori assumption about the number of clusters. Within the NMA_CFS procedure, a variable composite representation is devised to encode both feature selection and cluster centers with different numbers of clusters. Further, local search operations are introduced to refine feature selection and cluster centers encoded in the chromosomes. Finally, a niching method is integrated to preserve the population diversity and prevent premature convergence. In an experimental evaluation we demonstrate the effectiveness of the proposed approach and compare it with other related approaches, using both synthetic and real data
Supervised clustering of genes
BACKGROUND: We focus on microarray data where experiments monitor gene expression in different tissues and where each experiment is equipped with an additional response variable such as a cancer type. Although the number of measured genes is in the thousands, it is assumed that only a few marker components of gene subsets determine the type of a tissue. Here we present a new method for finding such groups of genes by directly incorporating the response variables into the grouping process, yielding a supervised clustering algorithm for genes. RESULTS: An empirical study on eight publicly available microarray datasets shows that our algorithm identifies gene clusters with excellent predictive potential, often superior to classification with state-of-the-art methods based on single genes. Permutation tests and bootstrapping provide evidence that the output is reasonably stable and more than a noise artifact. CONCLUSIONS: In contrast to other methods such as hierarchical clustering, our algorithm identifies several gene clusters whose expression levels clearly distinguish the different tissue types. The identification of such gene clusters is potentially useful for medical diagnostics and may at the same time reveal insights into functional genomics
CLUSTERING ALGORITHMS FOR CATEGORICAL DATA USING CONCEPTS OF SIGNIFICANCE AND DEPENDENCE OF ATTRIBUTES
Clustering categorical data is an essential and integral part of data mining. In this paper, we propose two new algorithms for clustering categorical data, namely, the Standard Deviation of Standard Deviation Significance and Standard Deviation of Standard Deviation Dependence algorithms. The proposed techniques are based mainly on rough set theory, taking into account the significance and dependence of attributes of database concepts. Analysis of the performance of the proposed algorithms compared with others shows their efficiency as well as ability to handle uncertainty together with categorical data
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