Cloud-Assisted Read Alignment and Privacy

Thanks to the rapid advances in sequencing technologies, genomic data is now being produced at an unprecedented rate. To adapt to this growth, several algorithms and paradigm shifts have been proposed to increase the throughput of the classical DNA workflow, e.g. by relying on the cloud to perform CPU intensive operations. However, the scientific community raised an alarm due to the possible privacy-related attacks that can be executed on genomic data. In this paper we review the state of the art in cloud-based alignment algorithms that have been developed for performance. We then present several privacy-preserving mechanisms that have been, or could be, used to align reads at an incremental performance cost. We finally argue for the use of risk analysis throughout the DNA workflow, to strike a balance between performance and protection of data

ERP implementation methodologies and frameworks: a literature review

Enterprise Resource Planning (ERP) implementation is a complex and vibrant process, one that involves a combination of technological and organizational interactions. Often an ERP implementation project is the single largest IT project that an organization has ever launched and requires a mutual fit of system and organization. Also the concept of an ERP implementation supporting business processes across many different departments is not a generic, rigid and uniform concept and depends on variety of factors. As a result, the issues addressing the ERP implementation process have been one of the major concerns in industry. Therefore ERP implementation receives attention from practitioners and scholars and both, business as well as academic literature is abundant and not always very conclusive or coherent. However, research on ERP systems so far has been mainly focused on diffusion, use and impact issues. Less attention has been given to the methods used during the configuration and the implementation of ERP systems, even though they are commonly used in practice, they still remain largely unexplored and undocumented in Information Systems research. So, the academic relevance of this research is the contribution to the existing body of scientific knowledge. An annotated brief literature review is done in order to evaluate the current state of the existing academic literature. The purpose is to present a systematic overview of relevant ERP implementation methodologies and frameworks as a desire for achieving a better taxonomy of ERP implementation methodologies. This paper is useful to researchers who are interested in ERP implementation methodologies and frameworks. Results will serve as an input for a classification of the existing ERP implementation methodologies and frameworks. Also, this paper aims also at the professional ERP community involved in the process of ERP implementation by promoting a better understanding of ERP implementation methodologies and frameworks, its variety and history

DR.SGX: Hardening SGX Enclaves against Cache Attacks with Data Location Randomization

Recent research has demonstrated that Intel's SGX is vulnerable to various software-based side-channel attacks. In particular, attacks that monitor CPU caches shared between the victim enclave and untrusted software enable accurate leakage of secret enclave data. Known defenses assume developer assistance, require hardware changes, impose high overhead, or prevent only some of the known attacks. In this paper we propose data location randomization as a novel defensive approach to address the threat of side-channel attacks. Our main goal is to break the link between the cache observations by the privileged adversary and the actual data accesses by the victim. We design and implement a compiler-based tool called DR.SGX that instruments enclave code such that data locations are permuted at the granularity of cache lines. We realize the permutation with the CPU's cryptographic hardware-acceleration units providing secure randomization. To prevent correlation of repeated memory accesses we continuously re-randomize all enclave data during execution. Our solution effectively protects many (but not all) enclaves from cache attacks and provides a complementary enclave hardening technique that is especially useful against unpredictable information leakage