Polynomial-Time Reasoning Support for Design and Maintenance of Large-Scale Biomedical Ontologies

Description Logics (DLs) belong to a successful family of knowledge representation formalisms with two key assets: formally well-defined semantics which allows to represent knowledge in an unambiguous way and automated reasoning which allows to infer implicit knowledge from the one given explicitly. This thesis investigates various reasoning techniques for tractable DLs in the EL family which have been implemented in the CEL system. It suggests that the use of the lightweight DLs, in which reasoning is tractable, is beneficial for ontology design and maintenance both in terms of expressivity and scalability. The claim is supported by a case study on the renown medical ontology SNOMED CT and extensive empirical evaluation on several large-scale biomedical ontologies

Standard and Non-standard reasoning in Description Logics

The present work deals with Description Logics (DLs), a class of knowledge representation formalisms used to represent and reason about classes of individuals and relations between such classes in a formally well-defined way. We provide novel results in three main directions. (1) Tractable reasoning revisited: in the 1990s, DL research has largely answered the question for practically relevant yet tractable DL formalisms in the negative. Due to novel application domains, especially the Life Sciences, and a surprising tractability result by Baader, we have re-visited this question, this time looking in a new direction: general terminologies (TBoxes) and extensions thereof defined over the DL EL and extensions thereof. As main positive result, we devise EL++(D)-CBoxes as a tractable DL formalism with optimal expressivity in the sense that every additional standard DL constructor, every extension of the TBox formalism, or every more powerful concrete domain, makes reasoning intractable. (2) Non-standard inferences for knowledge maintenance: non-standard inferences, such as matching, can support domain experts in maintaining DL knowledge bases in a structured and well-defined way. In order to extend their availability and promote their use, the present work extends the state of the art of non-standard inferences both w.r.t. theory and implementation. Our main results are implementations and performance evaluations of known matching algorithms for the DLs ALE and ALN, optimal non-deterministic polynomial time algorithms for matching under acyclic side conditions in ALN and sublanguages, and optimal algorithms for matching w.r.t. cyclic (and hybrid) EL-TBoxes. (3) Non-standard inferences over general concept inclusion (GCI) axioms: the utility of GCIs in modern DL knowledge bases and the relevance of non-standard inferences to knowledge maintenance naturally motivate the question for tractable DL formalism in which both can be provided. As main result, we propose hybrid EL-TBoxes as a solution to this hitherto open question

On the Computation of Common Subsumers in Description Logics

Description logics (DL) knowledge bases are often build by users with expertise in the application domain, but little expertise in logic. To support this kind of users when building their knowledge bases a number of extension methods have been proposed to provide the user with concept descriptions as a starting point for new concept definitions. The inference service central to several of these approaches is the computation of (least) common subsumers of concept descriptions. In case disjunction of concepts can be expressed in the DL under consideration, the least common subsumer (lcs) is just the disjunction of the input concepts. Such a trivial lcs is of little use as a starting point for a new concept definition to be edited by the user. To address this problem we propose two approaches to obtain "meaningful" common subsumers in the presence of disjunction tailored to two different methods to extend DL knowledge bases. More precisely, we devise computation methods for the approximation-based approach and the customization of DL knowledge bases, extend these methods to DLs with number restrictions and discuss their efficient implementation

Constructing and Extending Description Logic Ontologies using Methods of Formal Concept Analysis

Description Logic (abbrv. DL) belongs to the field of knowledge representation and reasoning. DL researchers have developed a large family of logic-based languages, so-called description logics (abbrv. DLs). These logics allow their users to explicitly represent knowledge as ontologies, which are finite sets of (human- and machine-readable) axioms, and provide them with automated inference services to derive implicit knowledge. The landscape of decidability and computational complexity of common reasoning tasks for various description logics has been explored in large parts: there is always a trade-off between expressibility and reasoning costs. It is therefore not surprising that DLs are nowadays applied in a large variety of domains: agriculture, astronomy, biology, defense, education, energy management, geography, geoscience, medicine, oceanography, and oil and gas. Furthermore, the most notable success of DLs is that these constitute the logical underpinning of the Web Ontology Language (abbrv. OWL) in the Semantic Web. Formal Concept Analysis (abbrv. FCA) is a subfield of lattice theory that allows to analyze data-sets that can be represented as formal contexts. Put simply, such a formal context binds a set of objects to a set of attributes by specifying which objects have which attributes. There are two major techniques that can be applied in various ways for purposes of conceptual clustering, data mining, machine learning, knowledge management, knowledge visualization, etc. On the one hand, it is possible to describe the hierarchical structure of such a data-set in form of a formal concept lattice. On the other hand, the theory of implications (dependencies between attributes) valid in a given formal context can be axiomatized in a sound and complete manner by the so-called canonical base, which furthermore contains a minimal number of implications w.r.t. the properties of soundness and completeness. In spite of the different notions used in FCA and in DLs, there has been a very fruitful interaction between these two research areas. My thesis continues this line of research and, more specifically, I will describe how methods from FCA can be used to support the automatic construction and extension of DL ontologies from data