REDUCED PEAK POWER SUPPLY USING CLOCK-TREE DRIVERS

Power noise analysis involves the straightforward Ohm low of multiplying peak current through the power network impedance. The noise can therefore be reduced by decreasing the impedance or staying away from high current peaks. We suggested lessening the height supply current and it is time derivative by distributing with time the switching from the clock-tree motorists, while keeping low skew in the sinks from the tree. We concentrate on lowering the peak current and it is time derivative, which has additionally been treated by various techniques. The time network thus remains an all natural candidate to deal with for optimum current remedy. To acquire proper and powerful sequencing from the logic, the time skew must stay within prescribed limits, not often exceeding 5% from the clock cycle. Once the recursion goes into a node (top-lower), fork substitution happens. Once the recursion returns in the node (bottom-up), delay equalization is resolved. Considerable noise reduction was recently explained using resonant clock distribution systems, generating sinusoidal signal. Its applicability to ordinary CMOS design is questionable because the short-circuit power within the clocked devices is considerably elevated. Driver's incoming wire inherits its triplet in the driver. Within the above convention the wires connecting outputs from the leaf motorists for their loads are assumed to call home at level 3. The very first is a high-lower traversal, in which the clock-tree is built along with a small peak current is acquired. Additionally, it helps to ensure that the skew in the tree's leaves doesn't escape. This is an excellent beginning point for any second, bottom-up traversal phase, aiming at skew nullification by fine adjustments from the clock-motorists positions. The 2nd phase includes a really small effect on the height current, which was already reduced within the first phase

Systems chronotherapeutics

Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms, which moderate xenobiotic metabolism and cellular drug response. The molecular clocks present in individual cells involve approximately fifteen clock genes interconnected in regulatory feedback loops. They are coordinated by the suprachiasmatic nuclei, a hypothalamic pacemaker, which also adjusts the circadian rhythms to environmental cycles. As a result, many mechanisms of diseases and drug effects are controlled by the circadian timing system. Thus, the tolerability of nearly 500 medications varies by up to fivefold according to circadian scheduling, both in experimental models and/or patients. Moreover, treatment itself disrupted, maintained, or improved the circadian timing system as a function of drug timing. Improved patient outcomes on circadian-based treatments (chronotherapy) have been demonstrated in randomized clinical trials, especially for cancer and inflammatory diseases. However, recent technological advances have highlighted large interpatient differences in circadian functions resulting in significant variability in chronotherapy response. Such findings advocate for the advancement of personalized chronotherapeutics through interdisciplinary systems approaches. Thus, the combination of mathematical, statistical, technological, experimental, and clinical expertise is now shaping the development of dedicated devices and diagnostic and delivery algorithms enabling treatment individualization. In particular, multiscale systems chronopharmacology approaches currently combine mathematical modeling based on cellular and whole-body physiology to preclinical and clinical investigations toward the design of patient-tailored chronotherapies. We review recent systems research works aiming to the individualization of disease treatment, with emphasis on both cancer management and circadian timing system–resetting strategies for improving chronic disease control and patient outcomes

Faculty Publications and Creative Works 2003

Faculty Publications & Creative Works is an annual compendium of scholarly and creative activities of University of New Mexico faculty during the noted calendar year. It serves to illustrate the robust and active intellectual pursuits conducted by the faculty in support of teaching and research at UNM

2011 IMSAloquium, Student Investigation Showcase

Inquiry Without Boundaries reflects our students’ infinite possibilities to explore their unique passions, develop new interests, and collaborate with experts around the globe.https://digitalcommons.imsa.edu/archives_sir/1003/thumbnail.jp

NASA SBIR abstracts of 1990 phase 1 projects

The research objectives of the 280 projects placed under contract in the National Aeronautics and Space Administration (NASA) 1990 Small Business Innovation Research (SBIR) Phase 1 program are described. The basic document consists of edited, non-proprietary abstracts of the winning proposals submitted by small businesses in response to NASA's 1990 SBIR Phase 1 Program Solicitation. The abstracts are presented under the 15 technical topics within which Phase 1 proposals were solicited. Each project was assigned a sequential identifying number from 001 to 280, in order of its appearance in the body of the report. The document also includes Appendixes to provide additional information about the SBIR program and permit cross-reference in the 1990 Phase 1 projects by company name, location by state, principal investigator, NASA field center responsible for management of each project, and NASA contract number