Identifying Potential Adverse Effects Using the Web: A New Approach to Medical Hypothesis Generation

Medical message boards are online resources where users with a particular condition exchange information, some of which they might not otherwise share with medical providers. Many of these boards contain a large number of posts and contain patient opinions and experiences that would be potentially useful to clinicians and researchers. We present an approach that is able to collect a corpus of medical message board posts, de-identify the corpus, and extract information on potential adverse drug effects discussed by users. Using a corpus of posts to breast cancer message boards, we identified drug event pairs using co-occurrence statistics. We then compared the identified drug event pairs with adverse effects listed on the package labels of tamoxifen, anastrozole, exemestane, and letrozole. Of the pairs identified by our system, 75–80% were documented on the drug labels. Some of the undocumented pairs may represent previously unidentified adverse drug effects

Feat: A Facebook Extraction And Analysis Toolkit

Social media usage has become mainstream. According to a recent study done by Edison Research in 2016, 78% of the U.S. population has a social media profile [8]. The number of active Facebook users is over one billion. In addition, 71% of adults use Facebook, which is the target of this thesis. Because Facebook is so widely used, it is also a popular medium for those wanting to promote their products and ideas, including presidential candidates. Many researchers have extracted data from social media sites, including Facebook, to predict the outcome of elections, to predict election turnout by political party, and to determine voter opinions. This thesis will discuss the development and use of a suite of tools for gathering and analyzing data collected from the social media site, Facebook. Although the suite of tools can be used to collect data from any public Facebook site, this thesis will specifically focus on using the tools to extract data from the pages of presidential candidates. In addition to extracting Facebook data and storing the data in a database, tools in the suite can be used to analyze and visualize the collected data

Text Mining Methods for Analyzing Online Health Information and Communication

The Internet provides an alternative way to share health information. Specifically, social network systems such as Twitter, Facebook, Reddit, and disease specific online support forums are increasingly being used to share information on health related topics. This could be in the form of personal health information disclosure to seek suggestions or answering other patients\u27 questions based on their history. This social media uptake gives a new angle to improve the current health communication landscape with consumer generated content from social platforms. With these online modes of communication, health providers can offer more immediate support to the people seeking advice. Non-profit organizations and federal agencies can also diffuse preventative information in such networks for better outcomes. Researchers in health communication can mine user generated content on social networks to understand themes and derive insights into patient experiences that may be impractical to glean through traditional surveys. The main difficulty in mining social health data is in separating the signal from the noise. Social data is characterized by informal nature of content, typos, emoticons, tonal variations (e.g. sarcasm), and ambiguities arising from polysemous words, all of which make it difficult in building automated systems for deriving insights from such sources. In this dissertation, we present four efforts to mine health related insights from user generated social data. In the first effort, we build a model to identify marketing tweets on electronic cigarettes (e-cigs) and assess different topics in marketing and non-marketing messages on e-cigs on Twitter. In our next effort, we build ensemble models to classify messages on a mental health forum for triaging posts whose authors need immediate attention from trained moderators to prevent self-harm. The third effort deals with models from our participation in a shared task on identifying tweets that discuss adverse drug reactions and those that mention medication intake. In the final task, we build a classifier that identifies whether a particular tweet about the popular Juul e-cig indicates the tweeter actually using the product. Our methods range from linear classifiers (e.g., logistic regression), classical nonlinear models (e.g., nearest neighbors), recent deep neural networks (e.g., convolutional neural networks), and ensembles of all these models in using different supervised training regimens (e.g., co-training). The focus is more on task specific system building than on building specific individual models. Overall, we demonstrate that it is possible to glean insights from social data on health related topics through natural language processing and machine learning with use-cases from substance use and mental health

Principles and Applications of Data Science

Data science is an emerging multidisciplinary field which lies at the intersection of computer science, statistics, and mathematics, with different applications and related to data mining, deep learning, and big data. This Special Issue on “Principles and Applications of Data Science” focuses on the latest developments in the theories, techniques, and applications of data science. The topics include data cleansing, data mining, machine learning, deep learning, and the applications of medical and healthcare, as well as social media

Predictive Analysis on Twitter: Techniques and Applications

Predictive analysis of social media data has attracted considerable attention from the research community as well as the business world because of the essential and actionable information it can provide. Over the years, extensive experimentation and analysis for insights have been carried out using Twitter data in various domains such as healthcare, public health, politics, social sciences, and demographics. In this chapter, we discuss techniques, approaches and state-of-the-art applications of predictive analysis of Twitter data. Specifically, we present fine-grained analysis involving aspects such as sentiment, emotion, and the use of domain knowledge in the coarse-grained analysis of Twitter data for making decisions and taking actions, and relate a few success stories

Utilizing Consumer Health Posts for Pharmacovigilance: Identifying Underlying Factors Associated with Patients’ Attitudes Towards Antidepressants

Non-adherence to antidepressants is a major obstacle to antidepressants therapeutic benefits, resulting in increased risk of relapse, emergency visits, and significant burden on individuals and the healthcare system. Several studies showed that non-adherence is weakly associated with personal and clinical variables, but strongly associated with patients’ beliefs and attitudes towards medications. The traditional methods for identifying the key dimensions of patients’ attitudes towards antidepressants are associated with some methodological limitations, such as concern about confidentiality of personal information. In this study, attempts have been made to address the limitations by utilizing patients’ self report experiences in online healthcare forums to identify underlying factors affecting patients attitudes towards antidepressants. The data source of the study was a healthcare forum called “askapatients.com”. 892 patients’ reviews were randomly collected from the forum for the four most commonly prescribed antidepressants including Sertraline (Zoloft) and Escitalopram (Lexapro) from SSRI class, and Venlafaxine (Effexor) and duloxetine (Cymbalta) from SNRI class. Methodology of this study is composed of two main phases: I) generating structured data from unstructured patients’ drug reviews and testing hypotheses concerning attitude, II) identification and normalization of Adverse Drug Reactions (ADRs), Withdrawal Symptoms (WDs) and Drug Indications (DIs) from the posts, and mapping them to both The UMLS and SNOMED CT concepts. Phase II also includes testing the association between ADRs and attitude. The result of the first phase of this study showed that “experience of adverse drug reactions”, “perceived distress received from ADRs”, “lack of knowledge about medication’s mechanism”, “withdrawal experience”, “duration of usage”, and “drug effectiveness” are strongly associated with patients attitudes. However, demographic variables including “age” and “gender” are not associated with attitude. Analysis of the data in second phase of the study showed that from 6,534 identified entities, 73% are ADRs, 12% are WDs, and 15 % are drug indications. In addition, psychological and cognitive expressions have higher variability than physiological expressions. All three types of entities were mapped to 811 UMLS and SNOMED CT concepts. Testing the association between ADRs and attitude showed that from twenty-one physiological ADRs specified in the ASEC questionnaire, “dry mouth”, “increased appetite”, “disorientation”, “yawning”, “weight gain”, and “problem with sexual dysfunction” are associated with attitude. A set of psychological and cognitive ADRs, such as “emotional indifference” and “memory problem were also tested that showed significance association between these types of ADRs and attitude. The findings of this study have important implications for designing clinical interventions aiming to improve patients\u27 adherence towards antidepressants. In addition, the dataset generated in this study has significant implications for improving performance of text-mining algorithms aiming to identify health related information from consumer health posts. Moreover, the dataset can be used for generating and testing hypotheses related to ADRs associated with psychiatric mediations, and identifying factors associated with discontinuation of antidepressants. The dataset and guidelines of this study are available at https://sites.google.com/view/pharmacovigilanceinpsychiatry/hom

Sentiment Analysis for Social Media

Sentiment analysis is a branch of natural language processing concerned with the study of the intensity of the emotions expressed in a piece of text. The automated analysis of the multitude of messages delivered through social media is one of the hottest research fields, both in academy and in industry, due to its extremely high potential applicability in many different domains. This Special Issue describes both technological contributions to the field, mostly based on deep learning techniques, and specific applications in areas like health insurance, gender classification, recommender systems, and cyber aggression detection