128,537 research outputs found
Designer cell signal processing circuits for biotechnology
Microorganisms are able to respond effectively to diverse signals from their environment and internal metabolism owing to their inherent sophisticated information processing capacity. A central aim of synthetic biology is to control and reprogramme the signal processing pathways within living cells so as to realise repurposed, beneficial applications ranging from disease diagnosis and environmental sensing to chemical bioproduction. To date most examples of synthetic biological signal processing have been built based on digital information flow, though analogue computing is being developed to cope with more complex operations and larger sets of variables. Great progress has been made in expanding the categories of characterised biological components that can be used for cellular signal manipulation, thereby allowing synthetic biologists to more rationally programme increasingly complex behaviours into living cells. Here we present a current overview of the components and strategies that exist for designer cell signal processing and decision making, discuss how these have been implemented in prototype systems for therapeutic, environmental, and industrial biotechnological applications, and examine emerging challenges in this promising field
Latency Optimized Asynchronous Early Output Ripple Carry Adder based on Delay-Insensitive Dual-Rail Data Encoding
Asynchronous circuits employing delay-insensitive codes for data
representation i.e. encoding and following a 4-phase return-to-zero protocol
for handshaking are generally robust. Depending upon whether a single
delay-insensitive code or multiple delay-insensitive code(s) are used for data
encoding, the encoding scheme is called homogeneous or heterogeneous
delay-insensitive data encoding. This article proposes a new latency optimized
early output asynchronous ripple carry adder (RCA) that utilizes single-bit
asynchronous full adders (SAFAs) and dual-bit asynchronous full adders (DAFAs)
which incorporate redundant logic and are based on the delay-insensitive
dual-rail code i.e. homogeneous data encoding, and follow a 4-phase
return-to-zero handshaking. Amongst various RCA, carry lookahead adder (CLA),
and carry select adder (CSLA) designs, which are based on homogeneous or
heterogeneous delay-insensitive data encodings which correspond to the
weak-indication or the early output timing model, the proposed early output
asynchronous RCA that incorporates SAFAs and DAFAs with redundant logic is
found to result in reduced latency for a dual-operand addition operation. In
particular, for a 32-bit asynchronous RCA, utilizing 15 stages of DAFAs and 2
stages of SAFAs leads to reduced latency. The theoretical worst-case latencies
of the different asynchronous adders were calculated by taking into account the
typical gate delays of a 32/28nm CMOS digital cell library, and a comparison is
made with their practical worst-case latencies estimated. The theoretical and
practical worst-case latencies show a close correlation....Comment: arXiv admin note: text overlap with arXiv:1704.0761
Indicating Asynchronous Array Multipliers
Multiplication is an important arithmetic operation that is frequently
encountered in microprocessing and digital signal processing applications, and
multiplication is physically realized using a multiplier. This paper discusses
the physical implementation of many indicating asynchronous array multipliers,
which are inherently elastic and modular and are robust to timing, process and
parametric variations. We consider the physical realization of many indicating
asynchronous array multipliers using a 32/28nm CMOS technology. The
weak-indication array multipliers comprise strong-indication or weak-indication
full adders, and strong-indication 2-input AND functions to realize the partial
products. The multipliers were synthesized in a semi-custom ASIC design style
using standard library cells including a custom-designed 2-input C-element. 4x4
and 8x8 multiplication operations were considered for the physical
implementations. The 4-phase return-to-zero (RTZ) and the 4-phase return-to-one
(RTO) handshake protocols were utilized for data communication, and the
delay-insensitive dual-rail code was used for data encoding. Among several
weak-indication array multipliers, a weak-indication array multiplier utilizing
a biased weak-indication full adder and the strong-indication 2-input AND
function is found to have reduced cycle time and power-cycle time product with
respect to RTZ and RTO handshaking for 4x4 and 8x8 multiplications. Further,
the 4-phase RTO handshaking is found to be preferable to the 4-phase RTZ
handshaking for achieving enhanced optimizations of the design metrics.Comment: arXiv admin note: text overlap with arXiv:1903.0943
Asynchronous Early Output Dual-Bit Full Adders Based on Homogeneous and Heterogeneous Delay-Insensitive Data Encoding
This paper presents the designs of asynchronous early output dual-bit full
adders without and with redundant logic (implicit) corresponding to homogeneous
and heterogeneous delay-insensitive data encoding. For homogeneous
delay-insensitive data encoding only dual-rail i.e. 1-of-2 code is used, and
for heterogeneous delay-insensitive data encoding 1-of-2 and 1-of-4 codes are
used. The 4-phase return-to-zero protocol is used for handshaking. To
demonstrate the merits of the proposed dual-bit full adder designs, 32-bit
ripple carry adders (RCAs) are constructed comprising dual-bit full adders. The
proposed dual-bit full adders based 32-bit RCAs incorporating redundant logic
feature reduced latency and area compared to their non-redundant counterparts
with no accompanying power penalty. In comparison with the weakly indicating
32-bit RCA constructed using homogeneously encoded dual-bit full adders
containing redundant logic, the early output 32-bit RCA comprising the proposed
homogeneously encoded dual-bit full adders with redundant logic reports
corresponding reductions in latency and area by 22.2% and 15.1% with no
associated power penalty. On the other hand, the early output 32-bit RCA
constructed using the proposed heterogeneously encoded dual-bit full adder
which incorporates redundant logic reports respective decreases in latency and
area than the weakly indicating 32-bit RCA that consists of heterogeneously
encoded dual-bit full adders with redundant logic by 21.5% and 21.3% with nil
power overhead. The simulation results obtained are based on a 32/28nm CMOS
process technology
Configurable 3D-integrated focal-plane sensor-processor array architecture
A mixed-signal Cellular Visual Microprocessor architecture with digital processors is
described. An ASIC implementation is also demonstrated. The architecture is composed of a
regular sensor readout circuit array, prepared for 3D face-to-face type integration, and one or
several cascaded array of mainly identical (SIMD) processing elements. The individual array
elements derived from the same general HDL description and could be of different in size, aspect
ratio, and computing resources
Efficient FPGA implementation of high-throughput mixed radix multipath delay commutator FFT processor for MIMO-OFDM
This article presents and evaluates pipelined architecture designs for an improved high-frequency Fast Fourier
Transform (FFT) processor implemented on Field Programmable Gate Arrays (FPGA) for Multiple Input Multiple Output
Orthogonal Frequency Division Multiplexing (MIMO-OFDM). The architecture presented is a Mixed-Radix Multipath Delay
Commutator. The presented parallel architecture utilizes fewer hardware resources compared to Radix-2 architecture,
while maintaining simple control and butterfly structures inherent to Radix-2 implementations. The high-frequency
design presented allows enhancing system throughput without requiring additional parallel data paths common in
other current approaches, the presented design can process two and four independent data streams in parallel
and is suitable for scaling to any power of two FFT size N. FPGA implementation of the architecture demonstrated
significant resource efficiency and high-throughput in comparison to relevant current approaches within
literature. The proposed architecture designs were realized with Xilinx System Generator (XSG) and evaluated
on both Virtex-5 and Virtex-7 FPGA devices. Post place and route results demonstrated maximum frequency
values over 400 MHz and 470 MHz for Virtex-5 and Virtex-7 FPGA devices respectively
Communication channel analysis and real time compressed sensing for high density neural recording devices
Next generation neural recording and Brain-
Machine Interface (BMI) devices call for high density or distributed
systems with more than 1000 recording sites. As the
recording site density grows, the device generates data on the
scale of several hundred megabits per second (Mbps). Transmitting
such large amounts of data induces significant power
consumption and heat dissipation for the implanted electronics.
Facing these constraints, efficient on-chip compression techniques
become essential to the reduction of implanted systems power
consumption. This paper analyzes the communication channel
constraints for high density neural recording devices. This paper
then quantifies the improvement on communication channel
using efficient on-chip compression methods. Finally, This paper
describes a Compressed Sensing (CS) based system that can
reduce the data rate by > 10x times while using power on
the order of a few hundred nW per recording channel
An efficient error resilience scheme based on wyner-ziv coding for region-of-Interest protection of wavelet based video transmission
In this paper, we propose a bandwidth efficient error resilience scheme for wavelet based video
transmission over wireless channel by introducing an additional Wyner-Ziv (WZ) stream to protect region of
interest (ROI) in a frame. In the proposed architecture, the main video stream is compressed by a generic
wavelet domain coding structure and passed through the error prone channel without any protection.
Meanwhile, the predefined ROI area related wavelet coefficients obtained after an integer wavelet transform
will be specially protected by WZ codec in an additional channel during transmission. At the decoder side, the error-prone ROI related wavelet coefficients will be used as side information to help decoding the WZ stream. Different size of WZ bit streams can be applied in order to meet different bandwidth condition and different
requirement of end users. The simulation results clearly revealed that the proposed scheme has distinct advantages in saving bandwidth comparing with fully applied FEC algorithm to whole video stream and in the meantime offer the robust transmission over error prone channel for certain video applications
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