Wired, wireless and wearable bioinstrumentation for high-precision recording of bioelectrical signals in bidirectional neural interfaces

It is widely accepted by the scientific community that bioelectrical signals, which can be used for the identification of neurophysiological biomarkers indicative of a diseased or pathological state, could direct patient treatment towards more effective therapeutic strategies. However, the design and realisation of an instrument that can precisely record weak bioelectrical signals in the presence of strong interference stemming from a noisy clinical environment is one of the most difficult challenges associated with the strategy of monitoring bioelectrical signals for diagnostic purposes. Moreover, since patients often have to cope with the problem of limited mobility being connected to bulky and mains-powered instruments, there is a growing demand for small-sized, high-performance and ambulatory biopotential acquisition systems in the Intensive Care Unit (ICU) and in High-dependency wards. Furthermore, electrical stimulation of specific target brain regions has been shown to alleviate symptoms of neurological disorders, such as Parkinson’s disease, essential tremor, dystonia, epilepsy etc. In recent years, the traditional practice of continuously stimulating the brain using static stimulation parameters has shifted to the use of disease biomarkers to determine the intensity and timing of stimulation. The main motivation behind closed-loop stimulation is minimization of treatment side effects by providing only the necessary stimulation required within a certain period of time, as determined from a guiding biomarker. Hence, it is clear that high-quality recording of local field potentials (LFPs) or electrocorticographic (ECoG) signals during deep brain stimulation (DBS) is necessary to investigate the instantaneous brain response to stimulation, minimize time delays for closed-loop neurostimulation and maximise the available neural data. To our knowledge, there are no commercial, small, battery-powered, wearable and wireless recording-only instruments that claim the capability of recording ECoG signals, which are of particular importance in closed-loop DBS and epilepsy DBS. In addition, existing recording systems lack the ability to provide artefact-free high-frequency (> 100 Hz) LFP recordings during DBS in real time primarily because of the contamination of the neural signals of interest by the stimulation artefacts. To address the problem of limited mobility often encountered by patients in the clinic and to provide a wide variety of high-precision sensor data to a closed-loop neurostimulation platform, a low-noise (8 nV/√Hz), eight-channel, battery-powered, wearable and wireless multi-instrument (55 × 80 mm2) was designed and developed. The performance of the realised instrument was assessed by conducting both ex vivo and in vivo experiments. The combination of desirable features and capabilities of this instrument, namely its small size (~one business card), its enhanced recording capabilities, its increased processing capabilities, its manufacturability (since it was designed using discrete off-the-shelf components), the wide bandwidth it offers (0.5 – 500 Hz) and the plurality of bioelectrical signals it can precisely record, render it a versatile tool to be utilized in a wide range of applications and environments. Moreover, in order to offer the capability of sensing and stimulating via the same electrode, novel real-time artefact suppression methods that could be used in bidirectional (recording and stimulation) system architectures are proposed and validated. More specifically, a novel, low-noise and versatile analog front-end (AFE), which uses a high-order (8th) analog Chebyshev notch filter to suppress the artefacts originating from the stimulation frequency, is presented. After defining the system requirements for concurrent LFP recording and DBS artefact suppression, the performance of the realised AFE is assessed by conducting both in vitro and in vivo experiments using unipolar and bipolar DBS (monophasic pulses, amplitude ranging from 3 to 6 V peak-to-peak, frequency 140 Hz and pulse width 100 µs). Under both in vitro and in vivo experimental conditions, the proposed AFE provided real-time, low-noise and artefact-free LFP recordings (in the frequency range 0.5 – 250 Hz) during stimulation. Finally, a family of tunable hardware filter designs and a novel method for real-time artefact suppression that enables wide-bandwidth biosignal recordings during stimulation are also presented. This work paves the way for the development of miniaturized research tools for closed-loop neuromodulation that use a wide variety of bioelectrical signals as control signals.Open Acces

Adaptive multibeam phased array design for a Spacelab experiment

The parametric tradeoff analyses and design for an Adaptive Multibeam Phased Array (AMPA) for a Spacelab experiment are described. This AMPA Experiment System was designed with particular emphasis to maximize channel capacity and minimize implementation and cost impacts for future austere maritime and aeronautical users, operating with a low gain hemispherical coverage antenna element, low effective radiated power, and low antenna gain-to-system noise temperature ratio

The design and implementation of a wideband digital radio receiver

Historically radio has been implemented using largely analogue circuitry. Improvements in mixed signal and digital signal processing technology are rapidly leading towards a largely digital approach, with down-conversion and filtering moving to the digital signal processing domain. Advantages of this technology include increased performance and functionality, as well as reduced cost. Wideband receivers place the heaviest demands on both mixed signal and digital signal processing technology, requiring high spurious free dynamic range (SFDR) and signal processing bandwidths. This dissertation investigates the extent to which current digital technology is able to meet these demands and compete with the proven architectures of analogue receivers. A scalable generalised digital radio receiver capable of operating in the HF and VHF bands was designed, implemented and tested, yielding instantaneous bandwidths in excess of 10 MHz with a spurious-free dynamic range exceeding 80 decibels below carrier (dBc). The results achieved reflect favourably on the digital receiver architecture. While the necessity for minimal analogue circuitry will possibly always exist, digital radio architectures are currently able to compete with analogue counterparts. The digital receiver is simple to manufacture, based on the use of largely commercial off-the-shelf (COTS) components, and exhibits extreme flexibility and high performance when compared with comparably priced analogue receivers

Conceptual design study for Infrared Limb Experiment (IRLE)

The phase A engineering design study for the Infrared Limb Experiment (IRLE) instrument, the infrared portion of the Mesosphere-Lower Thermosphere Explorer (MELTER) satellite payload is given. The IRLE instrument is a satellite instrument, based on the heritage of the Limb Infrared Monitor of the Stratosphere (LIMS) program, that will make global measurements of O3, CO2, NO, NO2, H2O, and OH from earth limb emissions. These measurements will be used to provide improved understanding of the photochemistry, radiation, dynamics, energetics, and transport phenomena in the lower thermosphere, mesosphere, and stratosphere. The IRLE instrument is the infrared portion of the MELTER satellite payload. MELTER is being proposed to NASA Goddard by a consortium consisting of the University of Michigan, University of Colorado and NASA Langley. It is proposed that the Space Dynamics Laboratory at Utah State University (SDL/USU) build the IRLE instrument for NASA Langley. MELTER is scheduled for launch in November 1994 into a sun-synchronous, 650-km circular orbit with an inclination angle of 97.8 deg and an ascending node at 3:00 p.m. local time

Interference rejection in FM receivers

"September 24, 1956." "This report is based on a thesis submitted to the Department of Electrical Engineering, M.I.T., May 16, 1956, in partial fulfillment of the requirements for the degree of Doctor of Science."Bibliography: p. 106.Army Signal Corps Contract DA36-039-sc-64637 Dept. of the Army Task 3-99-06-108 Project 3-99-00-100Elie J. Baghdady

Induction motor diagnosis by advanced notch FIR filters and the wigner-ville distribution

During the last years, several time-frequency decomposition tools have been applied for the diagnosis of induction motors, for those cases in which the traditional procedures, such as motor current signature analysis, cannot yield the necessary response. Among them, the Cohen distributions have been widely selected to study transient and even stationary operation due to their high-resolution and detailed information provided at all frequencies. Their main drawback, the cross-terms, has been tackled either modifying the distribution, or carrying out a pretreatment of the signal before computing its time-frequency decomposition. In this paper, a filtering process is proposed that uses advanced notch filters in order to remove constant frequency components present in the current of an induction motor, prior to the computation of its distribution, to study rotor asymmetries and mixed eccentricities. In transient operation of machines directly connected to the grid, this procedure effectively eliminates most of the artifacts that have prevented the use of these tools, allowing a wideband analysis and the definition of a precise quantification parameter able to follow the evolution of their state. © 1982-2012 IEEE

High performance continuous-time filters for information transfer systems

Vast attention has been paid to active continuous-time filters over the years. Thus as the cheap, readily available integrated circuit OpAmps replaced their discrete circuit versions, it became feasible to consider active-RC filter circuits using large numbers of OpAmps. Similarly the development of integrated operational transconductance amplifier (OTA) led to new filter configurations. This gave rise to OTA-C filters, using only active devices and capacitors, making it more suitable for integration. The demands on filter circuits have become ever more stringent as the world of electronics and communications has advanced. In addition, the continuing increase in the operating frequencies of modern circuits and systems increases the need for active filters that can perform at these higher frequencies; an area where the LC active filter emerges. What mainly limits the performance of an analog circuit are the non-idealities of the used building blocks and the circuit architecture. This research concentrates on the design issues of high frequency continuous-time integrated filters. Several novel circuit building blocks are introduced. A novel pseudo-differential fully balanced fully symmetric CMOS OTA architecture with inherent common-mode detection is proposed. Through judicious arrangement, the common-mode feedback circuit can be economically implemented. On the level of system architectures, a novel filter low-voltage 4th order RF bandpass filter structure based on emulation of two magnetically coupled resonators is presented. A unique feature of the proposed architecture is using electric coupling to emulate the effect of the coupled-inductors, thus providing bandwidth tuning with small passband ripple. As part of a direct conversion dual-mode 802.11b/Bluetooth receiver, a BiCMOS 5th order low-pass channel selection filter is designed. The filter operated from a single 2.5V supply and achieves a 76dB of out-of-band SFDR. A digital automatic tuning system is also implemented to account for process and temperature variations. As part of a Bluetooth transmitter, a low-power quadrature direct digital frequency synthesizer (DDFS) is presented. Piecewise linear approximation is used to avoid using a ROM look-up table to store the sine values in a conventional DDFS. Significant saving in power consumption, due to the elimination of the ROM, renders the design more suitable for portable wireless communication applications

Hybrid receiver study

The results are presented of a 4 month study to design a hybrid analog/digital receiver for outer planet mission probe communication links. The scope of this study includes functional design of the receiver; comparisons between analog and digital processing; hardware tradeoffs for key components including frequency generators, A/D converters, and digital processors; development and simulation of the processing algorithms for acquisition, tracking, and demodulation; and detailed design of the receiver in order to determine its size, weight, power, reliability, and radiation hardness. In addition, an evaluation was made of the receiver's capabilities to perform accurate measurement of signal strength and frequency for radio science missions