8,543 research outputs found
A combination of transcriptional and microRNA regulation improves the stability of the relative concentrations of target genes
It is well known that, under suitable conditions, microRNAs are able to fine
tune the relative concentration of their targets to any desired value. We show
that this function is particularly effective when one of the targets is a
Transcription Factor (TF) which regulates the other targets. This combination
defines a new class of feed-forward loops (FFLs) in which the microRNA plays
the role of master regulator. Using both deterministic and stochastic equations
we show that these FFLs are indeed able not only to fine-tune the TF/target
ratio to any desired value as a function of the miRNA concentration but also,
thanks to the peculiar topology of the circuit, to ensures the stability of
this ratio against stochastic fluctuations. These two effects are due to the
interplay between the direct transcriptional regulation and the indirect
TF/Target interaction due to competition of TF and target for miRNA binding
(the so called "sponge effect"). We then perform a genome wide search of these
FFLs in the human regulatory network and show that they are characterizedby a
very peculiar enrichment pattern. In particular they are strongly enriched in
all the situations in which the TF and its target have to be precisely kept at
the same concentration notwithstanding the environmental noise. As an example
we discuss the FFL involving E2F1 as Transcription Factor, RB1 as target and
miR-17 family as master regulator. These FFLs ensure a tight control of the
E2F/RB ratio which in turns ensures the stability of the transition from the
G0/G1 to the S phase in quiescent cells.Comment: 23 pages, 10 figure
Other Challenges in the Development of the Orbiter Environmental Control Hardware
Development of the Space Shuttle orbiter environmental control and life support system (ECLSS) included the identification and resolution of several interesting problems in several systems. Some of these problems occurred late in the program, including the flight phase. Problems and solutions related to the ammonia boiler system (ABS), smoke detector, water/hydrogen separator, and waste collector system (WCS) are addressed
Index to 1984 NASA Tech Briefs, volume 9, numbers 1-4
Short announcements of new technology derived from the R&D activities of NASA are presented. These briefs emphasize information considered likely to be transferrable across industrial, regional, or disciplinary lines and are issued to encourage commercial application. This index for 1984 Tech B Briefs contains abstracts and four indexes: subject, personal author, originating center, and Tech Brief Number. The following areas are covered: electronic components and circuits, electronic systems, physical sciences, materials, life sciences, mechanics, machinery, fabrication technology, and mathematics and information sciences
A Computer Algorithm For Engineering Off-Shell Multiplets With Four Supercharges On The World Sheet
We present an adinkra-based computer algorithm implemented in a Mathematica
code and use it in a limited demonstration of how to engineer off-shell,
arbitrary N-extended world-sheet supermultiplets. Using one of the outputs from
this algorithm, we present evidence for the unexpected discovery of a
previously unknown 8 - 8 representation of N = 2 world sheet supersymmetry. As
well, we uncover a menagerie of (p, q) = (3, 1) world sheet supermultiplets.Comment: 52 pages, 64 figures, LaTeX twice, added note in proof, addition of
comments about gauge invariance for 4D vector & tensor supermultiplet
Spacecraft high-voltage power supply construction
The design techniques, circuit components, fabrication techniques, and past experience used in successful high-voltage power supplies for spacecraft flight systems are described. A discussion of the basic physics of electrical discharges in gases is included and a design rationale for the prevention of electrical discharges is provided. Also included are typical examples of proven spacecraft high-voltage power supplies with typical specifications for design, fabrication, and testing
How Does the Cerebral Cortex Work? Developement, Learning, Attention, and 3D Vision by Laminar Circuits of Visual Cortex
A key goal of behavioral and cognitive neuroscience is to link brain mechanisms to behavioral functions. The present article describes recent progress towards explaining how the visual cortex sees. Visual cortex, like many parts of perceptual and cognitive neocortex, is organized into six main layers of cells, as well as characteristic sub-lamina. Here it is proposed how these layered circuits help to realize the processes of developement, learning, perceptual grouping, attention, and 3D vision through a combination of bottom-up, horizontal, and top-down interactions. A key theme is that the mechanisms which enable developement and learning to occur in a stable way imply properties of adult behavior. These results thus begin to unify three fields: infant cortical developement, adult cortical neurophysiology and anatomy, and adult visual perception. The identified cortical mechanisms promise to generalize to explain how other perceptual and cognitive processes work.Air Force Office of Scientific Research (F49620-01-1-0397); Office of Naval Research (N00014-01-1-0624
High-speed civil transport flight- and propulsion-control technological issues
Technology advances required in the flight and propulsion control system disciplines to develop a high speed civil transport (HSCT) are identified. The mission and requirements of the transport and major flight and propulsion control technology issues are discussed. Each issue is ranked and, for each issue, a plan for technology readiness is given. Certain features are unique and dominate control system design. These features include the high temperature environment, large flexible aircraft, control-configured empennage, minimizing control margins, and high availability and excellent maintainability. The failure to resolve most high-priority issues can prevent the transport from achieving its goals. The flow-time for hardware may require stimulus, since market forces may be insufficient to ensure timely production. Flight and propulsion control technology will contribute to takeoff gross weight reduction. Similar technology advances are necessary also to ensure flight safety for the transport. The certification basis of the HSCT must be negotiated between airplane manufacturers and government regulators. Efficient, quality design of the transport will require an integrated set of design tools that support the entire engineering design team
Active Temporal Multiplexing of Photons
Photonic qubits constitute a leading platform to disruptive quantum
technologies due to their unique low-noise properties. The cost of the photonic
approach is the non-deterministic nature of many of the processes, including
single-photon generation, which arises from parametric sources and negligible
interaction between photons. Active temporal multiplexing - repeating a
generation process in time and rerouting to single modes using an optical
switching network - is a promising approach to overcome this challenge and will
likely be essential for large-scale applications with greatly reduced resource
complexity and system sizes. Requirements include the precise synchronization
of a system of low-loss switches, delay lines, fast photon detectors, and
feed-forward. Here we demonstrate temporal multiplexing of 8 'bins' from a
double-passed heralded photon source and observe an increase in the heralding
and heralded photon rates. This system points the way to harnessing temporal
multiplexing in quantum technologies, from single-photon sources to large-scale
computation.Comment: Minor revision
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