Remodelage de la chromatine lors de l'activation transcriptionnelle synergique de cdx1 par l'acide rétinoïque et par Wnt3a

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal

The reproductive system of Opisthogonimus philodryadum (West, 1896) (Digenea)

O sistema reprodutor do adulto de Opisthogonimus philodryadum(West, 1896) foi estudado anatomica e histologicamente ao microscópio. Esta análise mostra que o canal de Laurer, metratermo, cirro e duto ejaculatório possuem um epitélio aprofundado. 0 metratermo e a franja citoplasmática do cirro ou tectum tem uma camada esclerótica diferenciada, semelhante em aspecto e cor às dos espinhos do tegumento do animal

Implication des modifications épigénétiques dans les cancers : développement de nouvelles approches thérapeutiques

Involvement of epigenetic modifications in cancers: development of new therapeutic approaches. Since cancer is the second cause of death after cardiovascular diseases in industrialized countries, it is urgent to elaborate new therapeutic approaches. Besides DNA mutations of essential genes, expansion of a cancer cell is frequently associated with epigenetic modifications i.e. not directly coded by the DNA sequence. Amongst epigenetic modifications, histones acetylation and DNA methylation are known to play important roles. In this context, a very promising anticancer therapy would be to correct epigenetic errors using compounds modulating histone acetylation and DNA methylation alone or in combination with other chemotherapeutic agents

Rôle d’une désorganisation de la chromatine dans la neurodégénérescence due à une expansion de polyglutamine dans l’ataxine-7

International audienc

Chromatin Flavors: Chromatin composition and domain organization in Drosophila melanogaster

Chromatin was originally identified by W. Flemming in 1882 as not much more than the stainable substance of the cell nucleus. Flemming named this substance according to the Greek word “chroma”, meaning color. In 1911 chromatin was characterized as proteins, named histones, that were attached to nucleic acid (DNA). In the following years it became clear that chromatin formed the structural basis of genetic information. Not until more than 30 years later the DNA, and not the histone proteins as was widely expected, was identified as the carrier of the genetic information. In 1952 the role of DNA in inheritance was confirmed and not much later Watson and Crick discovered the double-helical structure of DNA based on the DNA crystal analyses of Franklin, Gosling and Wilkins