54 research outputs found

    Computational Modeling of Facial Response for Detecting Differential Traits in Autism Spectrum Disorders

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    This dissertation proposes novel computational modeling and computer vision methods for the analysis and discovery of differential traits in subjects with Autism Spectrum Disorders (ASD) using video and three-dimensional (3D) images of face and facial expressions. ASD is a neurodevelopmental disorder that impairs an individual’s nonverbal communication skills. This work studies ASD from the pathophysiology of facial expressions which may manifest atypical responses in the face. State-of-the-art psychophysical studies mostly employ na¨ıve human raters to visually score atypical facial responses of individuals with ASD, which may be subjective, tedious, and error prone. A few quantitative studies use intrusive sensors on the face of the subjects with ASD, which in turn, may inhibit or bias the natural facial responses of these subjects. This dissertation proposes non-intrusive computer vision methods to alleviate these limitations in the investigation for differential traits from the spontaneous facial responses of individuals with ASD. Two IRB-approved psychophysical studies are performed involving two groups of age-matched subjects: one for subjects diagnosed with ASD and the other for subjects who are typically-developing (TD). The facial responses of the subjects are computed from their facial images using the proposed computational models and then statistically analyzed to infer about the differential traits for the group with ASD. A novel computational model is proposed to represent the large volume of 3D facial data in a small pose-invariant Frenet frame-based feature space. The inherent pose-invariant property of the proposed features alleviates the need for an expensive 3D face registration in the pre-processing step. The proposed modeling framework is not only computationally efficient but also offers competitive performance in 3D face and facial expression recognition tasks when compared with that of the state-ofthe-art methods. This computational model is applied in the first experiment to quantify subtle facial muscle response from the geometry of 3D facial data. Results show a statistically significant asymmetry in specific pair of facial muscle activation (p\u3c0.05) for the group with ASD, which suggests the presence of a psychophysical trait (also known as an ’oddity’) in the facial expressions. For the first time in the ASD literature, the facial action coding system (FACS) is employed to classify the spontaneous facial responses based on facial action units (FAUs). Statistical analyses reveal significantly (p\u3c0.01) higher prevalence of smile expression (FAU 12) for the ASD group when compared with the TD group. The high prevalence of smile has co-occurred with significantly averted gaze (p\u3c0.05) in the group with ASD, which is indicative of an impaired reciprocal communication. The metric associated with incongruent facial and visual responses suggests a behavioral biomarker for ASD. The second experiment shows a higher prevalence of mouth frown (FAU 15) and significantly lower correlations between the activation of several FAU pairs (p\u3c0.05) in the group with ASD when compared with the TD group. The proposed computational modeling in this dissertation offers promising biomarkers, which may aid in early detection of subtle ASD-related traits, and thus enable an effective intervention strategy in the future

    Social and Affective Neuroscience of Everyday Human Interaction

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    This Open Access book presents the current state of the art knowledge on social and affective neuroscience based on empirical findings. This volume is divided into several sections first guiding the reader through important theoretical topics within affective neuroscience, social neuroscience and moral emotions, and clinical neuroscience. Each chapter addresses everyday social interactions and various aspects of social interactions from a different angle taking the reader on a diverse journey. The last section of the book is of methodological nature. Basic information is presented for the reader to learn about common methodologies used in neuroscience alongside advanced input to deepen the understanding and usability of these methods in social and affective neuroscience for more experienced readers

    Pilot study for subgroup classification for autism spectrum disorder based on dysmorphology and physical measurements in Chinese children

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    Poster Sessions: 157 - Comorbid Medical Conditions: abstract 157.058 58BACKGROUND: Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder affecting individuals along a continuum of severity in communication, social interaction and behaviour. The impact of ASD significantly varies amongst individuals, and the cause of ASD can originate broadly between genetic and environmental factors. Objectives: Previous ASD researches indicate that early identification combined with a targeted treatment plan involving behavioural interventions and multidisciplinary therapies can provide substantial improvement for ASD patients. Currently there is no cure for ASD, and the clinical variability and uncertainty of the disorder still remains. Hence, the search to unravel heterogeneity within ASD by subgroup classification may provide clinicians with a better understanding of ASD and to work towards a more definitive course of action. METHODS: In this study, a norm of physical measurements including height, weight, head circumference, ear length, outer and inner canthi, interpupillary distance, philtrum, hand and foot length was collected from 658 Typical Developing (TD) Chinese children aged 1 to 7 years (mean age of 4.19 years). The norm collected was compared against 80 ASD Chinese children aged 1 to 12 years (mean age of 4.36 years). We then further attempted to find subgroups within ASD based on identifying physical abnormalities; individuals were classified as (non) dysmorphic with the Autism Dysmorphology Measure (ADM) from physical examinations of 12 body regions. RESULTS: Our results show that there were significant differences between ASD and TD children for measurements in: head circumference (p=0.009), outer (p=0.021) and inner (p=0.021) canthus, philtrum length (p=0.003), right (p=0.023) and left (p=0.20) foot length. Within the 80 ASD patients, 37(46%) were classified as dysmorphic (p=0.00). CONCLUSIONS: This study attempts to identify subgroups within ASD based on physical measurements and dysmorphology examinations. The information from this study seeks to benefit ASD community by identifying possible subtypes of ASD in Chinese population; in seek for a more definitive diagnosis, referral and treatment plan.published_or_final_versio

    Social and Affective Neuroscience of Everyday Human Interaction

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    This Open Access book presents the current state of the art knowledge on social and affective neuroscience based on empirical findings. This volume is divided into several sections first guiding the reader through important theoretical topics within affective neuroscience, social neuroscience and moral emotions, and clinical neuroscience. Each chapter addresses everyday social interactions and various aspects of social interactions from a different angle taking the reader on a diverse journey. The last section of the book is of methodological nature. Basic information is presented for the reader to learn about common methodologies used in neuroscience alongside advanced input to deepen the understanding and usability of these methods in social and affective neuroscience for more experienced readers

    Music Listening, Music Therapy, Phenomenology and Neuroscience

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    Facial EMG – Investigating the Interplay of Facial Muscles and Emotions

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    This chapter provides information about facial electromyography (EMG) as a method of investigating emotions and affect, including examples of application and methods for analysis. This chapter begins with a short introduction to emotion theory followed by an operationalisation of facial emotional expressions as an underlying requirement for their study using facial EMG. This chapter ends by providing practical information on the use of facial EMG

    Social and Affective Neuroscience of Embodiment

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    Embodiment has been discussed in the context of social, affective, and cognitive psychology, and also in the investigations of neuroscience in order to understand the relationship between biological mechanisms, body and cognitive, and social and affective processes. New theoretical models have been presented by researchers considering not only the sensory–motor interaction and the environment but also biological mechanisms regulating homeostasis and neural processes (Tsakiris M, Q J Exp Psychol 70(4):597–609, 2017). Historically, the body and the mind were comprehended as separate entities. The body was considered to function as a machine, responsible for providing sensory information to the mind and executing its commands. The mind, however, would process information in an isolated way, similar to a computer (Pecher D, Zwaan RA, Grounding cognition: the role of perception and action in memory, language, and thinking. Cambridge University Press, 2005). This mind and body perspective (Marmeleira J, Duarte Santos G, Percept Motor Skills 126, 2019; Marshall PJ, Child Dev Perspect 10(4):245–250, 2016), for many years, was the basis for studies in social and cognitive areas, in neuroscience, and clinical psychology

    Presence 2005: the eighth annual international workshop on presence, 21-23 September, 2005 University College London (Conference proceedings)

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    OVERVIEW (taken from the CALL FOR PAPERS) Academics and practitioners with an interest in the concept of (tele)presence are invited to submit their work for presentation at PRESENCE 2005 at University College London in London, England, September 21-23, 2005. The eighth in a series of highly successful international workshops, PRESENCE 2005 will provide an open discussion forum to share ideas regarding concepts and theories, measurement techniques, technology, and applications related to presence, the psychological state or subjective perception in which a person fails to accurately and completely acknowledge the role of technology in an experience, including the sense of 'being there' experienced by users of advanced media such as virtual reality. The concept of presence in virtual environments has been around for at least 15 years, and the earlier idea of telepresence at least since Minsky's seminal paper in 1980. Recently there has been a burst of funded research activity in this area for the first time with the European FET Presence Research initiative. What do we really know about presence and its determinants? How can presence be successfully delivered with today's technology? This conference invites papers that are based on empirical results from studies of presence and related issues and/or which contribute to the technology for the delivery of presence. Papers that make substantial advances in theoretical understanding of presence are also welcome. The interest is not solely in virtual environments but in mixed reality environments. Submissions will be reviewed more rigorously than in previous conferences. High quality papers are therefore sought which make substantial contributions to the field. Approximately 20 papers will be selected for two successive special issues for the journal Presence: Teleoperators and Virtual Environments. PRESENCE 2005 takes place in London and is hosted by University College London. The conference is organized by ISPR, the International Society for Presence Research and is supported by the European Commission's FET Presence Research Initiative through the Presencia and IST OMNIPRES projects and by University College London
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