3,650 research outputs found
Changes in the electroencephalographic spectrum in response to smoking cues in smokers and ex-smokers
Aims: To investigate the changes in the electroencephalographic (EEG) spectrum in smokers during exposure to a neutral and a smoking-related cue to determine whether these EEG changes are still present in ex-smokers after prolonged abstinence and to examine the relationship between the power in each spectral bandwidth and subjective craving. Methods: EEG frequencies in response to a smoking-related and a neutral cue were examined in 23 smokers and 21 ex-smokers, who quit smoking for 1.4 years on average. Additionally, self-report measures of cigarette craving and nicotine dependence were obtained. The spectral power of each bandwidth was computed, log-transformed, and analyzed using a within-subject design. Differences between EEG activity under neutral and smoking conditions were correlated with differences between pre- and postexperimental subjective craving. Results: Increases in reward craving (desire and intention to smoke) were associated with reduced theta activity, whereas increases in withdrawal craving (reduction of negative affect and withdrawal symptoms) were correlated with increases in both delta and higher alpha power. Furthermore, in smokers, but not in ex-smokers, a significant beta power increase was observed between the neutral condition and the smoking condition. Conclusion: Since the beta band is associated with arousal, attention, and alertness, it is suggested that the beta increase in response to the smoking cue might reflect an enhanced allocation of resources to smoking-related stimuli, i.e. a processing bias, which is an important feature of substance abuse. Since ex-smokers do not respond to the smoking cue with beta activity enhancement, we preliminarily conclude that smoking cues do not arouse ex-smokers or capture their attention as much as they do in smokers
Neurophysiological Profile of Antismoking Campaigns
Over the past few decades, antismoking public service announcements (PSAs) have been used by governments to promote healthy
behaviours in citizens, for instance, against drinking before the drive and against smoke. Effectiveness of such PSAs has been
suggested especially for young persons. By now, PSAs efficacy is still mainly assessed through traditional methods (questionnaires
and metrics) and could be performed only after the PSAs broadcasting, leading to waste of economic resources and time in the
case of Ineffective PSAs. One possible countermeasure to such ineffective use of PSAs could be promoted by the evaluation of the
cerebral reaction to the PSA of particular segments of population (e.g., old, young, and heavy smokers). In addition, it is crucial to
gather such cerebral activity in front of PSAs that have been assessed to be effective against smoke (Effective PSAs), comparing
results to the cerebral reactions to PSAs that have been certified to be not effective (Ineffective PSAs). &e eventual differences
between the cerebral responses toward the two PSA groups will provide crucial information about the possible outcome of new
PSAs before to its broadcasting. &is study focused on adult population, by investigating the cerebral reaction to the vision of
different PSA images, which have already been shown to be Effective and Ineffective for the promotion of an antismoking
behaviour. Results showed how variables as gender and smoking habits can influence the perception of PSA images, and how
different communication styles of the antismoking campaigns could facilitate the comprehension of PSA’s message and then
enhance the related impac
Electrophysiological responses to alcohol cues are not associated with Pavlovian-to-Instrumental Transfer in social drinkers
Peer reviewedPublisher PD
Biomarkers and neuromodulation techniques in substance use disorders
Addictive disorders are a severe health concern. Conventional therapies have just moderate success and the probability of relapse after treatment remains high. Brain stimulation techniques, such as transcranial Direct Current Stimulation (tDCS) and Deep Brain Stimulation (DBS), have been shown to be effective in reducing subjectively rated substance craving. However, there are few objective and measurable parameters that reflect neural mechanisms of addictive disorders and relapse. Key electrophysiological features that characterize substance related changes in neural processing are Event-Related Potentials (ERP). These high temporal resolution measurements of brain activity are able to identify neurocognitive correlates of addictive behaviours. Moreover, ERP have shown utility as biomarkers to predict treatment outcome and relapse probability. A future direction for the treatment of addiction might include neural interfaces able to detect addiction-related neurophysiological parameters and deploy neuromodulation adapted to the identified pathological features in a closed-loop fashion. Such systems may go beyond electrical recording and stimulation to employ sensing and neuromodulation in the pharmacological domain as well as advanced signal analysis and machine learning algorithms. In this review, we describe the state-of-the-art in the treatment of addictive disorders with electrical brain stimulation and its effect on addiction-related neurophysiological markers. We discuss advanced signal processing approaches and multi-modal neural interfaces as building blocks in future bioelectronics systems for treatment of addictive disorders
Intentional modulation of the late positive potential in response to smoking cues by cognitive strategies in smokers
Attentional bias is considered an important concept in addiction since it has been found to correlate with subjective craving and is strongly associated with relapse after periods of abstinence. Hence, investigating in ways to regulate attention for drug cues would be of major clinical relevance. The present study examined deliberate, cognitive modulation of motivated attention for smoking cues in smokers. The effects of three different reappraisal strategies on an electrophysiological measure of attentive processing were investigated. Early and late LPP components in response to passively viewed neutral and smoking pictures were compared with LPPs in response to smoking pictures that were reappraised with three different reappraisal strategies. Results show that when smokers actively imagine how pleasant it would be to smoke (pleasant condition), their early LPP in response to smoking cues increases, but when smokers actively focus on an alternative stimulus (distraction condition) or think of a rational, uninvolved interpretation of the situation (rational condition), smoking-related late LPP amplitude decreases to the processing level of neutral stimuli. Present results are the first to indicate that smoking cue-elicited LPP amplitudes can be modulated by cognitive strategies, suggesting that attentive processing of smoking cues can be intentionally regulated by smokers with various levels of dependence. Although cognitive strategies can lead to enhanced processing of smoking cues, it is not completely clear whether cognitive strategies are also successful in reducing smoking-related motivated attention. Although findings do point in this direction, present study is best considered preliminary and a starting point for other research on this topic. A focus on the distraction strategy is proposed, as there are indications that this strategy is more successful than the rational strategy in decreasing LPP amplitude
Emotional Graphic Cigarette Warning Labels Reduce the Electrophysiological Brain Response to Smoking Cues
There is an ongoing public debate about the new graphic warning labels (GWLs) that the Food and Drug Administration (FDA) proposes to place on cigarette packs. Tobacco companies argued that the strongly emotional images FDA proposed to include in the GWLs encroached on their constitutional rights. The court ruled that FDA did not provide sufficient scientific evidence of compelling public interest in such encroachment. This study\u27s objectives were to examine the effects of the GWLs on the electrophysiological and behavioral correlates of smoking addiction and to determine whether labels rated higher on the emotional reaction (ER) scale are associated with greater effects. We studied 25 non-treatment-seeking smokers. Event-related potentials (ERPs) were recorded while participants viewed a random sequence of paired images, in which visual smoking (Cues) or non-smoking (non-Cues) images were preceded by GWLs or neutral images. Participants reported their cigarette craving after viewing each pair. Dependent variables were magnitude of P300 ERPs and self-reported cigarette craving in response to Cues. We found that subjective craving response to Cues was significantly reduced by preceding GWLs, whereas the P300 amplitude response to Cues was reduced only by preceding GWLs rated high on the ER scale. In conclusion, our study provides experimental neuroscience evidence that weighs in on the ongoing public and legal debate about how to balance the constitutional and public health aspects of the FDA-proposed GWLs. The high toll of smoking-related illness and death adds urgency to the debate and prompts consideration of our findings while longitudinal studies of GWLs are underway
Nicotine enhances an auditory Event-Related Potential component which is inversely related to habituation
Nicotine is a psychoactive substance that is commonly consumed in the
context of music. However, the reason why music and nicotine are coconsumed
is uncertain. One possibility is that nicotine affects cognitive
processes relevant to aspects of music appreciation in a beneficial way.
Here we investigated this possibility using Event-Related Potentials (ERPs).
Participants underwent a simple decision-making task (to maintain
attentional focus), responses to which were signaled by auditory stimuli.
Unlike most previous research looking at the effects of nicotine on auditory
processing, we used tones of different pitch, a fundamental element of
music. In addition, unlike most other studies, we tested non-smoking
subjects to avoid withdrawal-related complications. We found that nicotine
(4.0 mg, administered as gum) increased P2 amplitude in the frontal
region. Since a decrease in P2 amplitude and latency is related to
habituation processes, and an enhanced ability to disengage from
irrelevant stimuli, our findings suggest that nicotine may cause a reduction
in habituation, resulting in non-smokers being less able to adapt to
repeated stimuli. A corollary of that decrease in adaptation may be that
nicotine extends the temporal window during which a listener is able and
willing to engage with a piece of music
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Reduction in N2 amplitude in response to deviant drug-related stimuli during a two-choice oddball task in long-term heroin abstainers
Rationale: Chronic heroin use can cause deficits in response inhibition, leading to a loss of control over drug use, particularly in the context of drug-related cues. Unfortunately, heightened incentive salience and motivational bias in response to drug-related cues may exist following abstinence from heroin use.
Objectives: The present study aimed to examine the effect of drug-related cues on response inhibition in long-term heroin abstainers.
Methods: Sixteen long-term (8–24 months) male heroin abstainers and 16 male healthy controls completed a modified two-choice oddball paradigm, in which a neutral “chair” picture served as frequent standard stimuli; the neutral and drug-related pictures served as infrequent deviant stimuli of different conditions respectively. Event-related potentials were compared across groups and conditions.
Results: Our results showed that heroin abstainers exhibited smaller N2d amplitude (deviant minus standard) in the drug cue condition compared to the neutral condition, due to smaller drug-cue deviant-N2 amplitude compared to neutral deviant-N2. Moreover, heroin abstainers had smaller N2d amplitude compared with the healthy controls in the drug cue condition, due to the heroin abstainers having reduced deviant-N2 amplitude compared to standard-N2 in the drug cue condition, which reversed in the healthy controls.
Conclusions: Our findings suggested that heroin addicts still show response inhibition deficits specifically for drug-related cues after longer-term abstinence. The inhibition-related N2 modulation for drug-related could be used as a novel electrophysiological index with clinical implications for assessing the risk of relapse and treatment outcome for heroin users
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