APEX2S: A Two-Layer Machine Learning Model for Discovery of host-pathogen protein-protein Interactions on Cloud-based Multiomics Data

Presented by the avalanche of biological interactions data, computational biology is now facing greater challenges on big data analysis and solicits more studies to mine and integrate cloud-based multiomics data, especially when the data are related to infectious diseases. Meanwhile, machine learning techniques have recently succeeded in different computational biology tasks. In this article, we have calibrated the focus for host-pathogen protein-protein interactions study, aiming to apply the machine learning techniques for learning the interactions data and making predictions. A comprehensive and practical workflow to harness different cloud-based multiomics data is discussed. In particular, a novel two-layer machine learning model, namely APEX2S, is proposed for discovery of the protein-protein interactions data. The results show that our model can better learn and predict from the accumulated host-pathogen protein-protein interactions

Still Wrong Use of Pairings in Cryptography

Several pairing-based cryptographic protocols are recently proposed with a wide variety of new novel applications including the ones in emerging technologies like cloud computing, internet of things (IoT), e-health systems and wearable technologies. There have been however a wide range of incorrect use of these primitives. The paper of Galbraith, Paterson, and Smart (2006) pointed out most of the issues related to the incorrect use of pairing-based cryptography. However, we noticed that some recently proposed applications still do not use these primitives correctly. This leads to unrealizable, insecure or too inefficient designs of pairing-based protocols. We observed that one reason is not being aware of the recent advancements on solving the discrete logarithm problems in some groups. The main purpose of this article is to give an understandable, informative, and the most up-to-date criteria for the correct use of pairing-based cryptography. We thereby deliberately avoid most of the technical details and rather give special emphasis on the importance of the correct use of bilinear maps by realizing secure cryptographic protocols. We list a collection of some recent papers having wrong security assumptions or realizability/efficiency issues. Finally, we give a compact and an up-to-date recipe of the correct use of pairings.Comment: 25 page