A phase-resolved XMM-Newton Campaign on the Colliding Wind Binary HD 152248

We report the first results of an XMM-Newton monitoring campaign of the NGC 6231 open cluster in the Sco OB1 association. This first paper focuses on the massive colliding wind binary HD 152248, which is the brightest X-ray source of the cluster. The campaign, with a total duration of 180 ksec, was split into six separate observations, following the orbital motion of HD 152248. The X-ray flux from this system presents a clear, asymmetric modulation with the phase and ranges from 0.73 to 1.18 10-12 erg s-1 cm-2 in the [0.5-10.0 keV] energy band. The maximum of the emission is reached slightly after apastron. The EPIC spectra are quite soft and peak around 0.8-0.9 keV. We characterize their shape using several combinations of mekal models and power-law spectra and we detect significant spectral variability in the [0.5-2.5 keV] energy band. We also perform 2-D hydrodynamical simulations using different sets of parameters that closely reproduce the physical and orbital configuration of the HD 152248 system at the time of the six XMM-Newton pointings. This allows a direct confrontation of the model predictions with the constraints deduced from the X-ray observations of the system. We show that the observed variation of the flux can be explained by a variation of the X-ray emission from the colliding wind zone, diluted by the softer X-ray contribution of the two O-type stars of the system. Our simulations also reveal that the interaction region of HD 152248 should be highly unstable, giving rise to shells of dense gas that are separated by low density regions. Finally, we perform a search for short-term variability in the light curves of the system and we show that trends are present within several of the 30 ksec exposures of our campaign. Further, most of these trends are in good .Comment: Accepted by MNRAS; 22 pages; without figures; complete PS version (including figures) on http://vela.astro.ulg.ac.be/Preprints/index.htm

Magnetized Accretion-Ejection Structures: 2.5D MHD simulations of continuous Ideal Jet launching from resistive accretion disks

We present numerical magnetohydrodynamic (MHD) simulations of a magnetized accretion disk launching trans-Alfvenic jets. These simulations, performed in a 2.5 dimensional time-dependent polytropic resistive MHD framework, model a resistive accretion disk threaded by an initial vertical magnetic field. The resistivity is only important inside the disk, and is prescribed as eta = alpha_m V_AH exp(-2Z^2/H^2), where V_A stands for Alfven speed, H is the disk scale height and the coefficient alpha_m is smaller than unity. By performing the simulations over several tens of dynamical disk timescales, we show that the launching of a collimated outflow occurs self-consistently and the ejection of matter is continuous and quasi-stationary. These are the first ever simulations of resistive accretion disks launching non-transient ideal MHD jets. Roughly 15% of accreted mass is persistently ejected. This outflow is safely characterized as a jet since the flow becomes super-fastmagnetosonic, well-collimated and reaches a quasi-stationary state. We present a complete illustration and explanation of the `accretion-ejection' mechanism that leads to jet formation from a magnetized accretion disk. In particular, the magnetic torque inside the disk brakes the matter azimuthally and allows for accretion, while it is responsible for an effective magneto-centrifugal acceleration in the jet. As such, the magnetic field channels the disk angular momentum and powers the jet acceleration and collimation. The jet originates from the inner disk region where equipartition between thermal and magnetic forces is achieved. A hollow, super-fastmagnetosonic shell of dense material is the natural outcome of the inwards advection of a primordial field.Comment: ApJ (in press), 32 pages, Higher quality version available at http://www-laog.obs.ujf-grenoble.fr/~fcass

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is the most common type of leukemia. The Cancer Genome Atlas Research Network has demonstrated the increasing genomic complexity of acute myeloid leukemia (AML). In addition, the network has facilitated our understanding of the molecular events leading to this deadly form of malignancy for which the prognosis has not improved over past decades. AML is a highly heterogeneous disease, and cytogenetics and molecular analysis of the various chromosome aberrations including deletions, duplications, aneuploidy, balanced reciprocal translocations and fusion of transcription factor genes and tyrosine kinases has led to better understanding and identification of subgroups of AML with different prognoses. Furthermore, molecular classification based on mRNA expression profiling has facilitated identification of novel subclasses and defined high-, poor-risk AML based on specific molecular signatures. However, despite increased understanding of AML genetics, the outcome for AML patients whose number is likely to rise as the population ages, has not changed significantly. Until it does, further investigation of the genomic complexity of the disease and advances in drug development are needed. In this review, leading AML clinicians and research investigators provide an up-to-date understanding of the molecular biology of the disease addressing advances in diagnosis, classification, prognostication and therapeutic strategies that may have significant promise and impact on overall patient survival

Research reports: 1985 NASA/ASEE Summer Faculty Fellowship Program

A compilation of 40 technical reports on research conducted by participants in the 1985 NASA/ASEE Summer Faculty Fellowship Program at Marshall Space Flight Center (MSFC) is given. Weibull density functions, reliability analysis, directional solidification, space stations, jet stream, fracture mechanics, composite materials, orbital maneuvering vehicles, stellar winds and gamma ray bursts are among the topics discussed

Interface engineering of graphene nanosheet reinforced ZrB2_2 composites by tuning surface contacts

The mechanical properties of heterophase interfaces are critically important for the behaviour of graphene-reinforced composites. In this work, the structure, adhesion, cleavage and sliding of heterophase interfaces, formed between a ZrB$_2$ matrix and graphene nanosheets, are systematically investigated by density functional theory, and compared to available experimental data. We demonstrate that the surface chemistry of the ZrB$_2$ matrix material largely shapes the interface structures (of either Zr-C-Zr or B-C-B type) and the nature of the interfacial interaction. The Zr-C-Zr interfaces present strong chemical bonding and their response to mechanical stress is significantly influenced by graphene corrugation. In contrast B-C-B interfaces, interacting through the relatively weak $\pi$-$\pi$ stacking, show attributes similar to 2D materials heterostructures. Our theoretical results provide insights into the interface bonding mechanisms in graphene/ceramic composites, and emphasize the prospect for their design via interface engineering enabled by surface contacts

Index to 1981 NASA Tech Briefs, volume 6, numbers 1-4

Short announcements of new technology derived from the R&D activities of NASA are presented. These briefs emphasize information considered likely to be transferrable across industrial, regional, or disciplinary lines and are issued to encourage commercial application. This index for 1981 Tech Briefs contains abstracts and four indexes: subject, personal author, originating center, and Tech Brief Number. The following areas are covered: electronic components and circuits, electronic systems, physical sciences, materials, life sciences, mechanics, machinery, fabrication technology, and mathematics and information sciences

Stellar granulation and interferometry

Stars are not smooth. Their photosphere is covered by a granulation pattern associated with the heat transport by convection. The convection-related surface structures have different size, depth, and temporal variations with respect to the stellar type. The related activity (in addition to other phenomena such as magnetic spots, rotation, dust, etc.) potentially causes bias in stellar parameters determination, radial velocity, chemical abundances determinations, and exoplanet transit detections. The role of long-baseline interferometric observations in this astrophysical context is crucial to characterize the stellar surface dynamics and correct the potential biases. In this Chapter, we present how the granulation pattern is expected for different kind of stellar types ranging from main sequence to extremely evolved stars of different masses and how interferometric techniques help to study their photospheric dynamics.Comment: To appear in the Book of the VLTI School 2013, held 9-21 Sep 2013 Barcelonnette (France), "What the highest angular resolution can bring to stellar astrophysics?", Ed. Millour, Chiavassa, Bigot, Chesneau, Meilland, Stee, EAS Publications Series (2015

Apricot melanoidins prevent oxidative endothelial cell death by counteracting mitochondrial oxidation and membrane depolarization

The cardiovascular benefits associated with diets rich in fruit and vegetables are thought to be due to phytochemicals contained in fresh plant material. However, whether processed plant foods provide the same benefits as unprocessed ones is an open question. Melanoidins from heat-processed apricots were isolated and their presence confirmed by colorimetric analysis and browning index. Oxidative injury of endothelial cells (ECs) is the key step for the onset and progression of cardiovascular diseases (CVD), therefore the potential protective effect of apricot melanoidins on hydrogen peroxide-induced oxidative mitochondrial damage and cell death was explored in human ECs. The redox state of cytoplasmic and mitochondrial compartments was detected by using the redox-sensitive, fluorescent protein (roGFP), while the mitochondrial membrane potential (MMP) was assessed with the fluorescent dye, JC-1. ECs exposure to hydrogen peroxide, dose-dependently induced mitochondrial and cytoplasmic oxidation. Additionally detected hydrogen peroxide-induced phenomena were MMP dissipation and ECs death. Pretreatment of ECs with apricot melanoidins, significantly counteracted and ultimately abolished hydrogen peroxide-induced intracellular oxidation, mitochondrial depolarization and cell death. In this regard, our current results clearly indicate that melanoidins derived from heat-processed apricots, protect human ECs against oxidative stress

The Alliance for Cellular Signaling Plasmid Collection: A Flexible Resource for Protein Localization Studies and Signaling Pathway Analysis

Cellular responses to inputs that vary both temporally and spatially are determined by complex relationships between the components of cell signaling networks. Analysis of these relationships requires access to a wide range of experimental reagents and techniques, including the ability to express the protein components of the model cells in a variety of contexts. As part of the Alliance for Cellular Signaling, we developed a robust method for cloning large numbers of signaling ORFs into Gateway® entry vectors, and we created a wide range of compatible expression platforms for proteomics applications. To date, we have generated over 3000 plasmids that are available to the scientific community via the American Type Culture Collection. We have established a website at www.signaling-gateway.org/data/plasmid/ that allows users to browse, search, and blast Alliance for Cellular Signaling plasmids. The collection primarily contains murine signaling ORFs with an emphasis on kinases and G protein signaling genes. Here we describe the cloning, databasing, and application of this proteomics resource for large scale subcellular localization screens in mammalian cell lines

Hidden magnetic order in CuNCN

We report a comprehensive experimental and theoretical study of the quasi-one-dimensional quantum magnet CuNCN. Based on magnetization measurements above room temperature as well as muon spin rotation and electron spin resonance measurements, we unequivocally establish the localized Cu+2-based magnetism and the magnetic transition around 70 K, both controversially discussed in the previous literature. Thermodynamic data conform to the uniform-spin-chain model with a nearest-neighbor intrachain coupling of about 2300 K, in remarkable agreement with the microscopic magnetic model based on density functional theory band-structure calculations. Using exact diagonalization and the coupled-cluster method, we derive a collinear antiferromagnetic order with a strongly reduced ordered moment of about 0.4 mu_B, indicating strong quantum fluctuations inherent to this quasi-one-dimensional spin system. We re-analyze the available neutron-scattering data, and conclude that they are not sufficient to resolve or disprove the magnetic order in CuNCN. By contrast, spectroscopic techniques indeed show signatures of long-range magnetic order below 70 K, yet with a rather broad distribution of internal field probed by implanted muons. We contemplate the possible structural origin of this effect and emphasize peculiar features of the microstructure studied with synchrotron powder x-ray diffraction.Comment: 17 pages, 17 figures, 1 tabl