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Lensfree computational microscopy tools for cell and tissue imaging at the point-of-care and in low-resource settings.
The recent revolution in digital technologies and information processing methods present important opportunities to transform the way optical imaging is performed, particularly toward improving the throughput of microscopes while at the same time reducing their relative cost and complexity. Lensfree computational microscopy is rapidly emerging toward this end, and by discarding lenses and other bulky optical components of conventional imaging systems, and relying on digital computation instead, it can achieve both reflection and transmission mode microscopy over a large field-of-view within compact, cost-effective and mechanically robust architectures. Such high throughput and miniaturized imaging devices can provide a complementary toolset for telemedicine applications and point-of-care diagnostics by facilitating complex and critical tasks such as cytometry and microscopic analysis of e.g., blood smears, Pap tests and tissue samples. In this article, the basics of these lensfree microscopy modalities will be reviewed, and their clinically relevant applications will be discussed
Signal Recovery in Perturbed Fourier Compressed Sensing
In many applications in compressed sensing, the measurement matrix is a
Fourier matrix, i.e., it measures the Fourier transform of the underlying
signal at some specified `base' frequencies , where is the
number of measurements. However due to system calibration errors, the system
may measure the Fourier transform at frequencies
that are different from the base frequencies and where
are unknown. Ignoring perturbations of this nature can lead to major errors in
signal recovery. In this paper, we present a simple but effective alternating
minimization algorithm to recover the perturbations in the frequencies \emph{in
situ} with the signal, which we assume is sparse or compressible in some known
basis. In many cases, the perturbations can be expressed
in terms of a small number of unique parameters . We demonstrate that
in such cases, the method leads to excellent quality results that are several
times better than baseline algorithms (which are based on existing off-grid
methods in the recent literature on direction of arrival (DOA) estimation,
modified to suit the computational problem in this paper). Our results are also
robust to noise in the measurement values. We also provide theoretical results
for (1) the convergence of our algorithm, and (2) the uniqueness of its
solution under some restrictions.Comment: New theortical results about uniqueness and convergence now included.
More challenging experiments now include
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