Causal Inference in Disease Spread across a Heterogeneous Social System

Diffusion processes are governed by external triggers and internal dynamics in complex systems. Timely and cost-effective control of infectious disease spread critically relies on uncovering the underlying diffusion mechanisms, which is challenging due to invisible causality between events and their time-evolving intensity. We infer causal relationships between infections and quantify the reflexivity of a meta-population, the level of feedback on event occurrences by its internal dynamics (likelihood of a regional outbreak triggered by previous cases). These are enabled by our new proposed model, the Latent Influence Point Process (LIPP) which models disease spread by incorporating macro-level internal dynamics of meta-populations based on human mobility. We analyse 15-year dengue cases in Queensland, Australia. From our causal inference, outbreaks are more likely driven by statewide global diffusion over time, leading to complex behavior of disease spread. In terms of reflexivity, precursory growth and symmetric decline in populous regions is attributed to slow but persistent feedback on preceding outbreaks via inter-group dynamics, while abrupt growth but sharp decline in peripheral areas is led by rapid but inconstant feedback via intra-group dynamics. Our proposed model reveals probabilistic causal relationships between discrete events based on intra- and inter-group dynamics and also covers direct and indirect diffusion processes (contact-based and vector-borne disease transmissions).Comment: arXiv admin note: substantial text overlap with arXiv:1711.0635

Quantifying knowledge exchange in R&D networks: A data-driven model

We propose a model that reflects two important processes in R&D activities of firms, the formation of R&D alliances and the exchange of knowledge as a result of these collaborations. In a data-driven approach, we analyze two large-scale data sets extracting unique information about 7500 R&D alliances and 5200 patent portfolios of firms. This data is used to calibrate the model parameters for network formation and knowledge exchange. We obtain probabilities for incumbent and newcomer firms to link to other incumbents or newcomers which are able to reproduce the topology of the empirical R&D network. The position of firms in a knowledge space is obtained from their patents using two different classification schemes, IPC in 8 dimensions and ISI-OST-INPI in 35 dimensions. Our dynamics of knowledge exchange assumes that collaborating firms approach each other in knowledge space at a rate $\mu$ for an alliance duration $\tau$. Both parameters are obtained in two different ways, by comparing knowledge distances from simulations and empirics and by analyzing the collaboration efficiency $\mathcal{\hat{C}}_{n}$. This is a new measure, that takes also in account the effort of firms to maintain concurrent alliances, and is evaluated via extensive computer simulations. We find that R&D alliances have a duration of around two years and that the subsequent knowledge exchange occurs at a very low rate. Hence, a firm's position in the knowledge space is rather a determinant than a consequence of its R&D alliances. From our data-driven approach we also find model configurations that can be both realistic and optimized with respect to the collaboration efficiency $\mathcal{\hat{C}}_{n}$. Effective policies, as suggested by our model, would incentivize shorter R&D alliances and higher knowledge exchange rates.Comment: 35 pages, 10 figure

Networks and the epidemiology of infectious disease

The science of networks has revolutionised research into the dynamics of interacting elements. It could be argued that epidemiology in particular has embraced the potential of network theory more than any other discipline. Here we review the growing body of research concerning the spread of infectious diseases on networks, focusing on the interplay between network theory and epidemiology. The review is split into four main sections, which examine: the types of network relevant to epidemiology; the multitude of ways these networks can be characterised; the statistical methods that can be applied to infer the epidemiological parameters on a realised network; and finally simulation and analytical methods to determine epidemic dynamics on a given network. Given the breadth of areas covered and the ever-expanding number of publications, a comprehensive review of all work is impossible. Instead, we provide a personalised overview into the areas of network epidemiology that have seen the greatest progress in recent years or have the greatest potential to provide novel insights. As such, considerable importance is placed on analytical approaches and statistical methods which are both rapidly expanding fields. Throughout this review we restrict our attention to epidemiological issues

Quantification and Comparison of Degree Distributions in Complex Networks

The degree distribution is an important characteristic of complex networks. In many applications, quantification of degree distribution in the form of a fixed-length feature vector is a necessary step. On the other hand, we often need to compare the degree distribution of two given networks and extract the amount of similarity between the two distributions. In this paper, we propose a novel method for quantification of the degree distributions in complex networks. Based on this quantification method,a new distance function is also proposed for degree distributions, which captures the differences in the overall structure of the two given distributions. The proposed method is able to effectively compare networks even with different scales, and outperforms the state of the art methods considerably, with respect to the accuracy of the distance function