Spartan Daily, September 2, 1983

Volume 81, Issue 5https://scholarworks.sjsu.edu/spartandaily/7055/thumbnail.jp

The future of molecular dynamics simulations in drug discovery

Molecular dynamics simulations can now track rapid processes—those occurring in less than about a millisecond—at atomic resolution for many biologically relevant systems. These simulations appear poised to exert a significant impact on how new drugs are found, perhaps even transforming the very process of drug discovery. We predict here future results we can expect from, and enhancements we need to make in, molecular dynamics simulations over the coming 25 years, and in so doing set out several Grand Challenges for the field. In the context of the problems now facing the pharmaceutical industry, we ask how we can best address drug discovery needs of the next quarter century using molecular dynamics simulations, and we suggest some possible approaches

Policies from Evidence that Risk Starvation Causes Dementias and Depressions and May Contribute to a Range of Other Brain Morbidities

In rich countries, the population percentage under drug therapy for depressions is rising rapidly decade by decade for children, adolescent and young adults with no evidence of any long term success for this chronic ailment. There is also in rich countries relative to most poor ones, for each age cohort, a dramatically higher incidence of dementias. This paper takes a fresh look at these evidences of happiness problems that are so much more prevalent in rich than poor countries...brain morbidities; brain exercise; decision making; dementia; depression; environmental factors; risk processing; risk starvation; whiffs of danger; frequent, tiny, varied chances and challenges, damaging social security welfare, socio-economic changes, societal interactions, societal contributions, pharmaceutical advertising' pharmaceutical sponsorship

Gendered Differences in Adolescent Body Image: Youth Agency, Protective andRisk Factors

This research examined youth agency and the micro-meso system environments (protective and risks) as they shaped adolescents’ body image. National data from 11,531 students (Grades 5-10) in the Health Behavior in School Aged Children survey (2009-2010) and commentaries from six education/health professionals were used. As predicted by the Iowa and Chicago Schools of Self Concept, parental figure protected youth against negative body image by shielding them against school bullying. But, the protection and risks associated with youth agency and the micro-meso systems were gendered and operated differently for male and female youth. Female negative body image models were more complex in the salience of protective and risk factors than male models. These findings added to the literature on adolescent health and endorsed the need for wrap-around role modeling and protection for adolescents

Spartan Daily, April 22, 1970

Volume 57, Issue 105https://scholarworks.sjsu.edu/spartandaily/5327/thumbnail.jp

Evaluation of the EVA Descriptor for QSAR Studies: 3. The use of a Genetic Algorithm to Search for Models with Enhanced Predictive Properties (EVA_GA)

The EVA structural descriptor, based upon calculated fundamental molecular vibrational frequencies, has proved to be an effective descriptor for both QSAR and database similarity calculations. The descriptor is sensitive to 3D structure but has an advantage over field-based 3D-QSAR methods inasmuch as structural superposition is not required. The original technique involves a standardisation method wherein uniform Gaussians of fixed standard deviation (σ) are used to smear out frequencies projected onto a linear scale. This smearing function permits the overlap of proximal frequencies and thence the extraction of a fixed dimensional descriptor regardless of the number and precise values of the frequencies. It is proposed here that there exist optimal localised values of σ in different spectral regions; that is, the overlap of frequencies using uniform Gaussians may, at certain points in the spectrum, either be insufficient to pick up relationships where they exist or mix up information to such an extent that significant correlations are obscured by noise. A genetic algorithm is used to search for optimal localised σ values using crossvalidated PLS regression scores as the fitness score to be optimised. The resultant models are then validated against a previously unseen test set of compounds. The performance of EVA_GA is compared to that of EVA and analogous CoMFA studies

The Boston University Photonics Center annual report 2015-2016

This repository item contains an annual report that summarizes activities of the Boston University Photonics Center in the 2015-2016 academic year. The report provides quantitative and descriptive information regarding photonics programs in education, interdisciplinary research, business innovation, and technology development. The Boston University Photonics Center (BUPC) is an interdisciplinary hub for education, research, scholarship, innovation, and technology development associated with practical uses of light.This has been a good year for the Photonics Center. In the following pages, you will see that this year the Center’s faculty received prodigious honors and awards, generated more than 100 notable scholarly publications in the leading journals in our field, and attracted $18.9M in new research grants/contracts. Faculty and staff also expanded their efforts in education and training, and cooperated in supporting National Science Foundation sponsored Sites for Research Experiences for Undergraduates and for Research Experiences for Teachers. As a community, we emphasized the theme of “Frontiers in Plasmonics as Enabling Science in Photonics and Beyond” at our annual symposium, hosted by Bjoern Reinhard. We continued to support the National Photonics Initiative, and contributed as a cooperating site in the American Institute for Manufacturing Integrated Photonics (AIM Photonics) which began this year as a new photonics-themed node in the National Network of Manufacturing Institutes. Highlights of our research achievements for the year include an ambitious new DoD-sponsored grant for Development of Less Toxic Treatment Strategies for Metastatic and Drug Resistant Breast Cancer Using Noninvasive Optical Monitoring led by Professor Darren Roblyer, continued support of our NIH-sponsored, Center for Innovation in Point of Care Technologies for the Future of Cancer Care led by Professor Cathy Klapperich, and an exciting confluence of new grant awards in the area of Neurophotonics led by Professors Christopher Gabel, Timothy Gardner, Xue Han, Jerome Mertz, Siddharth Ramachandran, Jason Ritt, and John White. Neurophotonics is fast becoming a leading area of strength of the Photonics Center. The Industry/University Collaborative Research Center, which has become the centerpiece of our translational biophotonics program, continues to focus onadvancing the health care and medical device industries, and has entered its sixth year of operation with a strong record of achievement and with the support of an enthusiastic industrial membership base

Focal Spot, Spring 1998

https://digitalcommons.wustl.edu/focal_spot_archives/1078/thumbnail.jp

Spartan Daily, September 29, 1988

Volume 91, Issue 22https://scholarworks.sjsu.edu/spartandaily/7748/thumbnail.jp