4,987 research outputs found
UMSL Bulletin 2023-2024
The 2023-2024 Bulletin and Course Catalog for the University of Missouri St. Louis.https://irl.umsl.edu/bulletin/1088/thumbnail.jp
INTEGRATED COMPUTER-AIDED DESIGN, EXPERIMENTATION, AND OPTIMIZATION APPROACH FOR PEROVSKITES AND PETROLEUM PACKAGING PROCESSES
According to the World Economic Forum report, the U.S. currently has an energy efficiency of just 30%, thus illustrating the potential scope and need for efficiency enhancement and waste minimization. In the U.S. energy sector, petroleum and solar energy are the two key pillars that have the potential to create research opportunities for transition to a cleaner, greener, and sustainable future. In this research endeavor, the focus is on two pivotal areas: (i) Computer-aided perovskite solar cell synthesis; and (ii) Optimization of flow processes through multiproduct petroleum pipelines. In the area of perovskite synthesis, the emphasis is on the enhancement of structural stability, lower costs, and sustainability. Utilizing modeling and optimization methods for computer-aided molecular design (CAMD), efficient, sustainable, less toxic, and economically viable alternatives to conventional lead-based perovskites are obtained. In the second area of optimization of flow processes through multiproduct petroleum pipelines, an actual industrial-scale operation for packaging multiple lube-oil blends is studied. Through an integrated approach of experimental characterization, process design, procedural improvements, testing protocols, control mechanisms, mathematical modeling, and optimization, the limitations of traditional packaging operations are identified, and innovative operational paradigms and strategies are developed by incorporating methods from process systems engineering and data-driven approaches
UMSL Bulletin 2022-2023
The 2022-2023 Bulletin and Course Catalog for the University of Missouri St. Louis.https://irl.umsl.edu/bulletin/1087/thumbnail.jp
Anwendungen maschinellen Lernens für datengetriebene Prävention auf Populationsebene
Healthcare costs are systematically rising, and current therapy-focused healthcare systems are not sustainable in the long run. While disease prevention is a viable instrument for reducing costs and suffering, it requires risk modeling to stratify populations, identify high- risk individuals and enable personalized interventions. In current clinical practice, however, systematic risk stratification is limited: on the one hand, for the vast majority of endpoints, no risk models exist. On the other hand, available models focus on predicting a single disease at a time, rendering predictor collection burdensome. At the same time, the den- sity of individual patient data is constantly increasing. Especially complex data modalities, such as -omics measurements or images, may contain systemic information on future health trajectories relevant for multiple endpoints simultaneously. However, to date, this data is inaccessible for risk modeling as no dedicated methods exist to extract clinically relevant information. This study built on recent advances in machine learning to investigate the ap- plicability of four distinct data modalities not yet leveraged for risk modeling in primary prevention. For each data modality, a neural network-based survival model was developed to extract predictive information, scrutinize performance gains over commonly collected covariates, and pinpoint potential clinical utility. Notably, the developed methodology was able to integrate polygenic risk scores for cardiovascular prevention, outperforming existing approaches and identifying benefiting subpopulations. Investigating NMR metabolomics, the developed methodology allowed the prediction of future disease onset for many common diseases at once, indicating potential applicability as a drop-in replacement for commonly collected covariates. Extending the methodology to phenome-wide risk modeling, elec- tronic health records were found to be a general source of predictive information with high systemic relevance for thousands of endpoints. Assessing retinal fundus photographs, the developed methodology identified diseases where retinal information most impacted health trajectories. In summary, the results demonstrate the capability of neural survival models to integrate complex data modalities for multi-disease risk modeling in primary prevention and illustrate the tremendous potential of machine learning models to disrupt medical practice toward data-driven prevention at population scale.Die Kosten im Gesundheitswesen steigen systematisch und derzeitige therapieorientierte Gesundheitssysteme sind nicht nachhaltig. Angesichts vieler verhinderbarer Krankheiten stellt die Prävention ein veritables Instrument zur Verringerung von Kosten und Leiden dar. Risikostratifizierung ist die grundlegende Voraussetzung für ein präventionszentri- ertes Gesundheitswesen um Personen mit hohem Risiko zu identifizieren und Maßnah- men einzuleiten. Heute ist eine systematische Risikostratifizierung jedoch nur begrenzt möglich, da für die meisten Krankheiten keine Risikomodelle existieren und sich verfüg- bare Modelle auf einzelne Krankheiten beschränken. Weil für deren Berechnung jeweils spezielle Sets an Prädiktoren zu erheben sind werden in Praxis oft nur wenige Modelle angewandt. Gleichzeitig versprechen komplexe Datenmodalitäten, wie Bilder oder -omics- Messungen, systemische Informationen über zukünftige Gesundheitsverläufe, mit poten- tieller Relevanz für viele Endpunkte gleichzeitig. Da es an dedizierten Methoden zur Ex- traktion klinisch relevanter Informationen fehlt, sind diese Daten jedoch für die Risikomod- ellierung unzugänglich, und ihr Potenzial blieb bislang unbewertet. Diese Studie nutzt ma- chinelles Lernen, um die Anwendbarkeit von vier Datenmodalitäten in der Primärpräven- tion zu untersuchen: polygene Risikoscores für die kardiovaskuläre Prävention, NMR Meta- bolomicsdaten, elektronische Gesundheitsakten und Netzhautfundusfotos. Pro Datenmodal- ität wurde ein neuronales Risikomodell entwickelt, um relevante Informationen zu extra- hieren, additive Information gegenüber üblicherweise erfassten Kovariaten zu quantifizieren und den potenziellen klinischen Nutzen der Datenmodalität zu ermitteln. Die entwickelte Me-thodik konnte polygene Risikoscores für die kardiovaskuläre Prävention integrieren. Im Falle der NMR-Metabolomik erschloss die entwickelte Methodik wertvolle Informa- tionen über den zukünftigen Ausbruch von Krankheiten. Unter Einsatz einer phänomen- weiten Risikomodellierung erwiesen sich elektronische Gesundheitsakten als Quelle prädik- tiver Information mit hoher systemischer Relevanz. Bei der Analyse von Fundusfotografien der Netzhaut wurden Krankheiten identifiziert für deren Vorhersage Netzhautinformationen genutzt werden könnten. Zusammengefasst zeigten die Ergebnisse das Potential neuronaler Risikomodelle die medizinische Praxis in Richtung einer datengesteuerten, präventionsori- entierten Medizin zu verändern
Tradition and Innovation in Construction Project Management
This book is a reprint of the Special Issue 'Tradition and Innovation in Construction Project Management' that was published in the journal Buildings
Recommended from our members
Exploring the socioeconomic and environmental factors influencing smallholder macadamia production and productivity in Malawi.
Macadamia (Macadamia integrifolia Maiden & Betche) is a highly valued crop in Malawi. The crop is a vital source of food security and ecosystem services, and its high-export cash value makes it a key contributor to the country's economy. Malawi ranks seventh in global macadamia production, comprising two subsectors: smallholders and commercial estates. However, significant yield gaps have been reported between smallholder and commercial estate producers. While commercial estates achieve higher average annual tree yields (30 kg), smallholder yields remain consistently low, averaging at or below 10 kg tree-1 year-1. Improving macadamia productivity among smallholders can help reduce poverty, improve household food security, and promote economic growth in Malawi.
Despite the significant contributions of smallholders in the Malawian macadamia subsector, research on the factors influencing the crop's productivity has primarily focused on commercial estate production. To address this knowledge gap, this Ph.D thesis focuses on smallholder macadamia production in Malawi. The thesis examines the socioeconomic characteristics of smallholder macadamia farmers, including demographics, cultivar preferences, and production constraints. Secondly, it evaluates the climatic factors influencing smallholder macadamia production and predicts the current and future suitable geographical areas for the crop. Lastly, it assesses the soil fertility status of smallholder macadamia farms in relation to macadamia production requirements.
Results of this study reveal that the majority (62%) of macadamia smallholders are over 50 years of age and consider farming their main occupation. However, this poses significant risks to the macadamia subsector, as older farmers are risk-averse and less innovative, hindering their willingness to adopt new agricultural technologies and ability to learn. Regarding cultivar preferences, the study finds that smallholder macadamia farmers prefer high-yielding cultivars with superior nut qualities, such as large and heavy nuts, and extended flowering periods. The most preferred macadamia cultivars in descending order are Hawaiian Agricultural Experimental Station (HAES) 660, 800, 816, and 246, which are the "core" of established cultivars in Malawi. The study identifies insect pests, diseases, market availability, strong winds, and a lack of agricultural extension services as the most significant challenges affecting smallholder macadamia farmers.
The study's suitability analysis reveals that the ensemble model has an excellent fit and high performance in predicting the current agro-climatically suitable areas for macadamia production (AUC = 0.90). The findings show that precipitation related variables (60.2%) are more important in determining the suitable areas for growing macadamia than temperature related variables (39.8%). The model results show that 57% (53,925 km2) of Malawi is currently suitable for macadamia cultivation, with the central region having the highest suitability (25.8%, 24,327 km2) and the southern region the lowest (10.7%, 10,257 km2). Optimal suitability (26%, 24,565 km2) is observed in the highland areas with elevations ranging from 1000–1400 metres above sea level (m.a.s.l.). Under the intermediate emission scenario (RCP 4.5) and the pessimistic scenario (RCP 8.5), the impact models predict net losses of 18% (17,015 km2) and 21.6% (20,414 km2), respectively, in the extent of suitable areas for macadamia in the 2050s.
The results of the soil fertility analysis indicate suboptimal fertility among the sampled macadamia farms. The majority of the soils are strongly acidic and deficient in essential nutrients required for the healthy growth of macadamia trees. Moreover, the average cation exchange capacity (1.67 cmol (+) kg-1) and the soil organic matter content (≤ 1%) are below the minimum optimal levels required for macadamia trees. These findings indicate that soil fertility is one of the primary limiting factors to the crop's productivity, even in areas with suitable climatic conditions. Therefore, addressing the soil fertility issues is crucial to improving the land suitability of the smallholder farms for macadamia, which can lead to optimal yields.
This study extends the frontiers of knowledge concerning the macadamia subsector in Malawi by providing insights into the smallholder macadamia farming systems, including demographics, cultivar preferences, and production constraints. It also provides novel empirical evidence on the climate factors that influence the suitability of rainfed macadamia cultivation and identifies current and future suitable growing areas in the country. Additionally, the study addresses the research gap on the soil fertility status of Malawian smallholder macadamia farms. Therefore, the findings of this research have practical implications for various areas such as macadamia cultivar introductions and breeding, land use planning, soil fertility management, and policy formulation for agricultural extension services, inputs, and marketing of the crop
- …