Broadband Dielectric Spectroscopy with a Microwave Ablation Antenna

Microwave ablation is a technique used to treat tumorous tissue. Its clinical use has been greatly expanding in the last few years. Because the design of the ablation antenna and the success of the treatment greatly depend on the accurate knowledge of the dielectric properties of the tissue being treated, it is highly valuable to have a microwave ablation antenna that is also able to perform in-situ dielectric spectroscopy. In this work, an open-ended coaxial slot ablation antenna design operating at 5.8 GHz is adopted from previous work, and its sensing abilities and limitations are investigated in respect of the dimensions of the material under test. Numerical simulations were performed to investigate the functionality of the floating sleeve of the antenna and to find the optimal de-embedding model and calibration option for obtaining accurate dielectric properties of the area of interest. Results show that, as in the case of the open-ended coaxial probe, the accuracy of the measurement greatly depends on the likeness between the calibration standards' dielectric properties and the material under test. Finally, the results of this paper clarify to which extent the antenna can be used to measure dielectric properties and paves the way to future improvements and the introduction of this functionality into microwave thermal ablation treatments

3D/2D Registration of Mapping Catheter Images for Arrhythmia Interventional Assistance

Radiofrequency (RF) catheter ablation has transformed treatment for tachyarrhythmias and has become first-line therapy for some tachycardias. The precise localization of the arrhythmogenic site and the positioning of the RF catheter over that site are problematic: they can impair the efficiency of the procedure and are time consuming (several hours). Electroanatomic mapping technologies are available that enable the display of the cardiac chambers and the relative position of ablation lesions. However, these are expensive and use custom-made catheters. The proposed methodology makes use of standard catheters and inexpensive technology in order to create a 3D volume of the heart chamber affected by the arrhythmia. Further, we propose a novel method that uses a priori 3D information of the mapping catheter in order to estimate the 3D locations of multiple electrodes across single view C-arm images. The monoplane algorithm is tested for feasibility on computer simulations and initial canine data.Comment: International Journal of Computer Science Issues, IJCSI, Volume 4, Issue 2, pp10-19, September 200

Temperature Effects of Dielectric Properties and their Impact on Medical Device Development

Dielectric properties play an influential role in the development of medical devices. Understanding the behavior of these properties and how they respond to external stimuli, such as heat, over an extended frequency has yet to be researched. The focus of this study is to examine the impact of temperature on dielectric properties from 500 MHz to 10 GHz in order to better match the antenna properties of medical applications to the dielectric properties of biological tissue in question; more specifically, microwave ablation, microwave hyperthermia, and thermal modeling of brown adipose tissue’s metabolic processes. The dielectric properties of biological tissue samples from porcine lung, liver, heart, skin, fat, and muscle as well as brown adipose tissue and white adipose tissue from rat have been tested. These results have then been used to develop medical applications involving microwave antennas

A computational model of open-irrigated radiofrequency catheter ablation accounting for mechanical properties of the cardiac tissue

Radiofrequency catheter ablation (RFCA) is an effective treatment for cardiac arrhythmias. Although generally safe, it is not completely exempt from the risk of complications. The great flexibility of computational models can be a major asset in optimizing interventional strategies, if they can produce sufficiently precise estimations of the generated lesion for a given ablation protocol. This requires an accurate description of the catheter tip and the cardiac tissue. In particular, the deformation of the tissue under the catheter pressure during the ablation is an important aspect that is overlooked in the existing literature, that resorts to a sharp insertion of the catheter into an undeformed geometry. As the lesion size depends on the power dissipated in the tissue, and the latter depends on the percentage of the electrode surface in contact with the tissue itself, the sharp insertion geometry has the tendency to overestimate the lesion obtained, especially when a larger force is applied to the catheter. In this paper we introduce a full 3D computational model that takes into account the tissue elasticity, and is able to capture the tissue deformation and realistic power dissipation in the tissue. Numerical results in FEniCS-HPC are provided to validate the model against experimental data, and to compare the lesions obtained with the new model and with the classical ones featuring a sharp electrode insertion in the tissue.La Caixa 2016 PhD grant to M. Leoni, and Abbott non-conditional grant to J.M. Guerra Ramo

Thermal dosimetry for bladder hyperthermia treatment. An overview.

The urinary bladder is a fluid-filled organ. This makes, on the one hand, the internal surface of the bladder wall relatively easy to heat and ensures in most cases a relatively homogeneous temperature distribution; on the other hand the variable volume, organ motion, and moving fluid cause artefacts for most non-invasive thermometry methods, and require additional efforts in planning accurate thermal treatment of bladder cancer. We give an overview of the thermometry methods currently used and investigated for hyperthermia treatments of bladder cancer, and discuss their advantages and disadvantages within the context of the specific disease (muscle-invasive or non-muscle-invasive bladder cancer) and the heating technique used. The role of treatment simulation to determine the thermal dose delivered is also discussed. Generally speaking, invasive measurement methods are more accurate than non-invasive methods, but provide more limited spatial information; therefore, a combination of both is desirable, preferably supplemented by simulations. Current efforts at research and clinical centres continue to improve non-invasive thermometry methods and the reliability of treatment planning and control software. Due to the challenges in measuring temperature across the non-stationary bladder wall and surrounding tissues, more research is needed to increase our knowledge about the penetration depth and typical heating pattern of the various hyperthermia devices, in order to further improve treatments. The ability to better determine the delivered thermal dose will enable clinicians to investigate the optimal treatment parameters, and consequentially, to give better controlled, thus even more reliable and effective, thermal treatments

Multitechnique testing of the viscous decretion disk model I. The stable and tenuous disk of the late-type Be star β\beta CMi

The viscous decretion disk (VDD) model is able to explain most of the currently observable properties of the circumstellar disks of Be stars. However, more stringent tests, focusing on reproducing multitechnique observations of individual targets via physical modeling, are needed to study the predictions of the VDD model under specific circumstances. In the case of nearby, bright Be star $\beta$ CMi, these circumstances are a very stable low-density disk and a late-type (B8Ve) central star. The aim is to test the VDD model thoroughly, exploiting the full diagnostic potential of individual types of observations, in particular, to constrain the poorly known structure of the outer disk if possible, and to test truncation effects caused by a possible binary companion using radio observations. We use the Monte Carlo radiative transfer code HDUST to produce model observables, which we compare with a very large set of multitechnique and multiwavelength observations that include ultraviolet and optical spectra, photometry covering the interval between optical and radio wavelengths, optical polarimetry, and optical and near-IR (spectro)interferometry. Due to the absence of large scale variability, data from different epochs can be combined into a single dataset. A parametric VDD model with radial density exponent of $n$ = 3.5, which is the canonical value for isothermal flaring disks, is found to explain observables typically formed in the inner disk, while observables originating in the more extended parts favor a shallower, $n$ = 3.0, density falloff. Modeling of radio observations allowed for the first determination of the physical extent of a Be disk (35$^{+10}_{-5}$ stellar radii), which might be caused by a binary companion. Finally, polarization data allowed for an indirect measurement of the rotation rate of the star, which was found to be $W \gtrsim 0.98$, i.e., very close to critical.Comment: 19 pages (35 including online material), 17 figures, 2 online figures, 2 online tables with dat

Incorporating Distributed Debris Thickness in a Glacio-Hydrological Model: Khumbu Himalaya, Nepal

Understanding the future evolution of Himalayan glaciers is important in terms of runoff that provides an essential water source to local populations and has far-reaching downstream impacts. However, the climatic response of glaciers in High-Mountain Asia is complicated by ice stagnation and considerable supraglacial debris coverage, which insulates the ice from warming. Typical runoff modelling only crudely incorporates debris cover and there is currently no consensus on how significantly this may impact future glacier and runoff evolution. Here, a glacio-hydrological model is modified to incorporate fully distributed debris cover, using melt reduction factors that vary depending on debris thickness, and to redistribute mass losses according to observed surface elevation changes. A range of debris thickness data are implemented, including a remote-sensing survey and a modelled debris surface, to analyse the sensitivity of glacier evolution and runoff to possible future debris-cover changes in a series of experiments in the upper Khumbu catchment, Nepal. Simulations are undertaken using climate input data from Regional Climate Model simulations from CORDEX (Coordinated Regional Downscaling Experiment) which are further statistically downscaled using data from the Pyramid meteorological station. Results suggest that the accurate calibration of the model to volume change compensates for the inclusion of distributed debris cover but only if the climatic sensitivity of the calibration period (1999–2010) and the nature of the debris-covered surface remain constant during future simulations. Altering the nature of the debris surface has a significant impact on simulated ice volume, with melt rates under debris suppressed by up to 85 %. The sensitivity of runoff ranges from 60 to 140 million m3 yr-1, although there are considerable uncertainties relating to non-glacial snow melt. Moreover, incorporating locally enhanced melt at ice cliffs into the model also impacts upon volume loss and discharge, with a greater proportion of ice cliffs leading to enhanced volume losses compared to a homogeneous debris surface. Finally, using the most representative model configuration, the future evolution of Khumbu Glacier under various climate scenarios shows continued mass losses with a reduction in volume ranging from 60 % to 97 % by 2100. Runoff trends show an initial increase followed by an eventual decrease, with runoff in 2100 predicted to be 8 % lower than current levels