Design and implementation of miniaturised capsule for autofluorescence detection with possible application to the bowel disease

Early signs of intestinal cancer may be detected through variations in tissue autofluorescence (AF), however current endoscope-based AF systems are unable to inspect the small intestine. This thesis describes the design, fabrication, implantation, testing and packaging of a wireless pill capable of detecting the autofluorescence from cancerous cells, and able to reach parts of the gastrointestinal tract that are inaccessible to endoscopes. The pill exploits the fact that there is a significant difference in the intensity of autofluorescence emitted by normal and cancerous tissues when excited by a blue or ultra violet light source. The intensity differences are detected using very sensitive light detectors. The pill has been developed in two stages. The first stage starts with using an off-chip multi-pixel photon counter (MPPC) device as a light detector. In the second stage, the light detector is integrated into an application specific integrated circuit (ASIC). The pill comprises of an ASIC, optical filters, an information processing unit and a radio transmission unit, to transmit acquired data to an external base station. Two ASICs have been fabricated, the first stage of this work involved implementing an ASIC that contains two main blocks; the first block is capable of providing a variable DC voltage more than 72 V from a 3 V input to bias the MPPC device. The second main block is a front-end consisting of a high speed transimpedance amplifier (TIA) and voltage amplifiers to capture the very small current pulses produced by the MPPC. The second ASIC contains a high voltage charge pump up to (37.9 V) integrated with a single photon avalanche detector (SPAD). The charge pump is used to bias the SPAD above its breakdown voltage and therefore operate the device in Geiger mode. The SPAD was designed to operate in the visible region where its photon detection efficiency (PDE) peaks at 465 nm, which is near to human tissues autofluorescence peaking region (520±10 nm). The use of the ultra low light detector to detect the autofluorescence permits a lower excitation light intensity and therefore lower overall power consumption. The two ASICs were fabricated using a commercial triple-well high-voltage CMOS process. The complete device operates at 3V and draws an average of 7.1mA, enabling up to 23 hours of continuous operation from two 165mAh SR44 batteries

Modern Telemetry

Telemetry is based on knowledge of various disciplines like Electronics, Measurement, Control and Communication along with their combination. This fact leads to a need of studying and understanding of these principles before the usage of Telemetry on selected problem solving. Spending time is however many times returned in form of obtained data or knowledge which telemetry system can provide. Usage of telemetry can be found in many areas from military through biomedical to real medical applications. Modern way to create a wireless sensors remotely connected to central system with artificial intelligence provide many new, sometimes unusual ways to get a knowledge about remote objects behaviour. This book is intended to present some new up to date accesses to telemetry problems solving by use of new sensors conceptions, new wireless transfer or communication techniques, data collection or processing techniques as well as several real use case scenarios describing model examples. Most of book chapters deals with many real cases of telemetry issues which can be used as a cookbooks for your own telemetry related problems

VLSI Design

This book provides some recent advances in design nanometer VLSI chips. The selected topics try to present some open problems and challenges with important topics ranging from design tools, new post-silicon devices, GPU-based parallel computing, emerging 3D integration, and antenna design. The book consists of two parts, with chapters such as: VLSI design for multi-sensor smart systems on a chip, Three-dimensional integrated circuits design for thousand-core processors, Parallel symbolic analysis of large analog circuits on GPU platforms, Algorithms for CAD tools VLSI design, A multilevel memetic algorithm for large SAT-encoded problems, etc