95 research outputs found

    Bereavement reduces neutrophil oxidative burst only in older adults: role of the HPA axis and immunesenescence

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    Background The effect of the chronic stress of bereavement on immunity is poorly understood. Previous studies have demonstrated negative effects on immunity in older adults, and those who report higher depressive symptoms. The aim of the present study was to compare the effect of bereavement on neutrophil function in healthy young and old adults, also assessing serum levels of the stress hormones, cortisol and dehydroepiandrosterone sulphate (DHEAS). 41 young (mean age 32 years) and 52 older adults (mean age 72 years), bereaved and non-bereaved, took part in the study. They completed questionnaires on socio-demographic and health behaviour characteristics, as well as psychosocial variables, and provided a blood sample for analysis of neutrophil function (phagocytosis and reactive oxygen species (ROS) production) and stress hormone analysis. Results Bereaved participants in both age groups reported more symptoms of depression and anxiety than controls and scored moderately highly on bereavement-specific questionnaires for these symptoms. Despite this, young bereaved participants showed robust neutrophil function when compared to age-matched non-bereaved controls, and comparable stress hormone levels, while reduced neutrophil ROS production and raised stress hormone levels (cortisol:DHEAS ratio) were seen in the older bereaved group compared to their age-matched controls. Conclusions Reduced neutrophil function among older bereaved participants may be the result of the inability to maintain stress hormone balance, specifically the cortisol:DHEAS ratio

    Spartan Daily, April 21, 1978

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    Volume 70, Issue 51https://scholarworks.sjsu.edu/spartandaily/6342/thumbnail.jp

    Anomers Of D-Galactosamine Benzoates

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    D-Galactosamine has been known as one of the rarer amino sugars, occurring widely distributed in small concentrations in living organisms. The biological importance of D-galactosamine and its derivatives was thought to justify a study of the chemical properties of this group of compounds. As a result of this study the reactions of D-galactosamine have been found to differ more than previously thought from those of D-glucosamine, the more common amino sugar For this investigation D-galactosamine hydrochloride was isolated from chondroitin sulfate, a polysaccharide obtained from the cartilaginous tissues of animals. This was changed by appropriate reactions to the 1,3,4,6-tetra-0-benzoyl-N-carbobenzoxy-α-β-D-galactosamine (III). This sirup, when reacted with hydrogen bromide in glacial acetic acid, produced 3,4,6-tri-o-benzoyl-l-bromo-α-D-galactosamine bydrobromide (IV), which was used as the starting material for the subsequent reactions

    The Carroll News- Vol. 51, No. 3

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    The Carroll News- Vol. 51, No. 3

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    The College News, November 17, 1953

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    The College News, 1957-02-13, Vol. 43, No. 12

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    Bryn Mawr College student newspaper. Merged with The Haverford News in 1968 to form the Bi-college News (with various titles from 1968 on). Published weekly (except holidays) during the academic year

    The Trail, 1938-02-11

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    https://soundideas.pugetsound.edu/thetrail_all/1443/thumbnail.jp
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