12,506 research outputs found
Prostate Cancer Nodal Staging: Using Deep Learning to Predict 68Ga-PSMA-Positivity from CT Imaging Alone
Lymphatic spread determines treatment decisions in prostate cancer (PCa) patients. 68Ga-PSMA-PET/CT can be performed, although cost remains high and availability is limited. Therefore, computed tomography (CT) continues to be the most used modality for PCa staging. We assessed if convolutional neural networks (CNNs) can be trained to determine 68Ga-PSMA-PET/CT-lymph node status from CT alone. In 549 patients with 68Ga-PSMA PET/CT imaging, 2616 lymph nodes were segmented. Using PET as a reference standard, three CNNs were trained. Training sets balanced for infiltration status, lymph node location and additionally, masked images, were used for training. CNNs were evaluated using a separate test set and performance was compared to radiologists' assessments and random forest classifiers. Heatmaps maps were used to identify the performance determining image regions. The CNNs performed with an Area-Under-the-Curve of 0.95 (status balanced) and 0.86 (location balanced, masked), compared to an AUC of 0.81 of experienced radiologists. Interestingly, CNNs used anatomical surroundings to increase their performance, "learning" the infiltration probabilities of anatomical locations. In conclusion, CNNs have the potential to build a well performing CT-based biomarker for lymph node metastases in PCa, with different types of class balancing strongly affecting CNN performance
Multi-Level Batch Normalization In Deep Networks For Invasive Ductal Carcinoma Cell Discrimination In Histopathology Images
Breast cancer is the most diagnosed cancer and the most predominant cause of
death in women worldwide. Imaging techniques such as the breast cancer
pathology helps in the diagnosis and monitoring of the disease. However
identification of malignant cells can be challenging given the high
heterogeneity in tissue absorbotion from staining agents. In this work, we
present a novel approach for Invasive Ductal Carcinoma (IDC) cells
discrimination in histopathology slides. We propose a model derived from the
Inception architecture, proposing a multi-level batch normalization module
between each convolutional steps. This module was used as a base block for the
feature extraction in a CNN architecture. We used the open IDC dataset in which
we obtained a balanced accuracy of 0.89 and an F1 score of 0.90, thus
surpassing recent state of the art classification algorithms tested on this
public dataset.Comment: 4 pages, 5 figure
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