Chile's experience with stabilization, revisited

This paper evaluates Chile's stabilization policies since the early 1970s. Four episodes are examined: (a) the high inflation at the beginning of the military regime when inflation was close to 1000 percent per year; (b) the orthodox stabilization program of 1975; (c) the exchange rate-based stabilization of February 1978-June 1982; and (d) the post-1984 adjustment period with a large real devaluation and low inflation. Finally an overall evaluation of the post-1973 experience with stabilization is provided.Economic Theory&Research,Economic Stabilization,Environmental Economics&Policies,Macroeconomic Management,Access to Markets

A Hilbert C*-module admitting no frames

We show that every infinite-dimensional commutative unital C*-algebra has a Hilbert C*-module admitting no frames. In particular, this shows that Kasparov's stabilization theorem for countably generated Hilbert C*-modules can not be extended to arbitrary Hilbert C*-modules.Comment: Minor change. To appear in Bull. Lond. Math. So

RNA-Binding protein HuR and the members of miR-200 family play an unconventional role in the regulation of c-Jun mRNA

Post-transcriptional gene regulation is a fundamental step for coordinating cellular response in a variety of processes. RNA-binding proteins (RBPs) and microRNAs (miRNAs) are the most important factors responsible for this regulation. Here we report that different components of the miR-200 family are involved in c-Jun mRNA regulation with the opposite effect. While miR-200b inhibits c-Jun protein production, miR-200a tends to increase the JUN amount through a stabilization of its mRNA. This action is dependent on the presence of the RBP HuR that binds the 3′UTR of c-Jun mRNA in a region including the mir-200a binding site. The position of the binding site is fundamental; by mutating this site, we demonstrate that the effect is not micro-RNA specific. These results indicate that miR-200a triggers a microRNA-mediated stabilization of c-Jun mRNA, promoting the binding of HuR with c-Jun mRNA. This is the first example of a positive regulation exerted by a microRNA on an important oncogene in proliferating cells