Breast Cancer Automatic Diagnosis System using Faster Regional Convolutional Neural Networks

Breast cancer is one of the most frequent causes of mortality in women. For the early detection of breast cancer, the mammography is used as the most efficient technique to identify abnormalities such as tumors. Automatic detection of tumors in mammograms has become a big challenge and can play a crucial role to assist doctors in order to achieve an accurate diagnosis. State-of-the-art Deep Learning algorithms such as Faster Regional Convolutional Neural Networks are able to determine the presence of an object and also its position inside the image in a reduced computation time. In this work, we evaluate these algorithms to detect tumors in mammogram images and propose a detection system that contains: (1) a preprocessing step performed on mammograms taken from the Digital Database for Screening Mammography (DDSM) and (2) the Neural Network model, which performs feature extraction over the mammograms in order to locate tumors within each image and classify them as malignant or benign. The results obtained show that the proposed algorithm has an accuracy of 97.375%. These results show that the system could be very useful for aiding physicians when detecting tumors from mammogram images.Ministerio de Economía y Competitividad TEC2016-77785-

Computer aided diagnosis system for breast cancer using deep learning.

The recent rise of big data technology surrounding the electronic systems and developed toolkits gave birth to new promises for Artificial Intelligence (AI). With the continuous use of data-centric systems and machines in our lives, such as social media, surveys, emails, reports, etc., there is no doubt that data has gained the center of attention by scientists and motivated them to provide more decision-making and operational support systems across multiple domains. With the recent breakthroughs in artificial intelligence, the use of machine learning and deep learning models have achieved remarkable advances in computer vision, ecommerce, cybersecurity, and healthcare. Particularly, numerous applications provided efficient solutions to assist radiologists and doctors for medical imaging analysis, which has remained the essence of the visual representation that is used to construct the final observation and diagnosis. Medical research in cancerology and oncology has been recently blended with the knowledge gained from computer engineering and data science experts. In this context, an automatic assistance or commonly known as Computer-aided Diagnosis (CAD) system has become a popular area of research and development in the last decades. As a result, the CAD systems have been developed using multidisciplinary knowledge and expertise and they have been used to analyze the patient information to assist clinicians and practitioners in their decision-making process. Treating and preventing cancer remains a crucial task that radiologists and oncologists face every day to detect and investigate abnormal tumors. Therefore, a CAD system could be developed to provide decision support for many applications in the cancer patient care processes, such as lesion detection, characterization, cancer staging, tumors assessment, recurrence, and prognosis prediction. Breast cancer has been considered one of the common types of cancers in females across the world. It was also considered the leading cause of mortality among women, and it has been increased drastically every year. Early detection and diagnosis of abnormalities in screened breasts has been acknowledged as the optimal solution to examine the risk of developing breast cancer and thus reduce the increasing mortality rate. Accordingly, this dissertation proposes a new state-of-the-art CAD system for breast cancer diagnosis that is based on deep learning technology and cutting-edge computer vision techniques. Mammography screening has been recognized as the most effective tool to early detect breast lesions for reducing the mortality rate. It helps reveal abnormalities in the breast such as Mass lesion, Architectural Distortion, Microcalcification. With the number of daily patients that were screened is continuously increasing, having a second reading tool or assistance system could leverage the process of breast cancer diagnosis. Mammograms could be obtained using different modalities such as X-ray scanner and Full-Field Digital mammography (FFDM) system. The quality of the mammograms, the characteristics of the breast (i.e., density, size) or/and the tumors (i.e., location, size, shape) could affect the final diagnosis. Therefore, radiologists could miss the lesions and consequently they could generate false detection and diagnosis. Therefore, this work was motivated to improve the reading of mammograms in order to increase the accuracy of the challenging tasks. The efforts presented in this work consists of new design and implementation of neural network models for a fully integrated CAD system dedicated to breast cancer diagnosis. The approach is designed to automatically detect and identify breast lesions from the entire mammograms at a first step using fusion models’ methodology. Then, the second step only focuses on the Mass lesions and thus the proposed system should segment the detected bounding boxes of the Mass lesions to mask their background. A new neural network architecture for mass segmentation was suggested that was integrated with a new data enhancement and augmentation technique. Finally, a third stage was conducted using a stacked ensemble of neural networks for classifying and diagnosing the pathology (i.e., malignant, or benign), the Breast Imaging Reporting and Data System (BI-RADS) assessment score (i.e., from 2 to 6), or/and the shape (i.e., round, oval, lobulated, irregular) of the segmented breast lesions. Another contribution was achieved by applying the first stage of the CAD system for a retrospective analysis and comparison of the model on Prior mammograms of a private dataset. The work was conducted by joining the learning of the detection and classification model with the image-to-image mapping between Prior and Current screening views. Each step presented in the CAD system was evaluated and tested on public and private datasets and consequently the results have been fairly compared with benchmark mammography datasets. The integrated framework for the CAD system was also tested for deployment and showcase. The performance of the CAD system for the detection and identification of breast masses reached an overall accuracy of 97%. The segmentation of breast masses was evaluated together with the previous stage and the approach achieved an overall performance of 92%. Finally, the classification and diagnosis step that defines the outcome of the CAD system reached an overall pathology classification accuracy of 96%, a BIRADS categorization accuracy of 93%, and a shape classification accuracy of 90%. Results given in this dissertation indicate that our suggested integrated framework might surpass the current deep learning approaches by using all the proposed automated steps. Limitations of the proposed work could occur on the long training time of the different methods which is due to the high computation of the developed neural networks that have a huge number of the trainable parameters. Future works can include new orientations of the methodologies by combining different mammography datasets and improving the long training of deep learning models. Moreover, motivations could upgrade the CAD system by using annotated datasets to integrate more breast cancer lesions such as Calcification and Architectural distortion. The proposed framework was first developed to help detect and identify suspicious breast lesions in X-ray mammograms. Next, the work focused only on Mass lesions and segment the detected ROIs to remove the tumor’s background and highlight the contours, the texture, and the shape of the lesions. Finally, the diagnostic decision was predicted to classify the pathology of the lesions and investigate other characteristics such as the tumors’ grading assessment and type of the shape. The dissertation presented a CAD system to assist doctors and experts to identify the risk of breast cancer presence. Overall, the proposed CAD method incorporates the advances of image processing, deep learning, and image-to-image translation for a biomedical application

注目領域検出のための視覚的注意モデル設計に関する研究

Visual attention is an important mechanism in the human visual system. When human observe images and videos, they usually do not describe all the contents in them. Instead, they tend to talk about the semantically important regions and objects in the images. The human eye is usually attracted by some regions of interest rather than the entire scene. These regions of interest that present the mainly meaningful or semantic content are called saliency region. Visual saliency detection refers to the use of intelligent algorithms to simulate human visual attention mechanism, extract both the low-level features and high-level semantic information and localize the salient object regions in images and videos. The generated saliency map indicates the regions that are likely to attract human attention. As a fundamental problem of image processing and computer vision, visual saliency detection algorithms have been extensively studied by researchers to solve practical tasks, such as image and video compression, image retargeting, object detection, etc. The visual attention mechanism adopted by saliency detection in general are divided into two categories, namely the bottom-up model and top-down model. The bottom-up attention algorithm focuses on utilizing the low-level visual features such as colour and edges to locate the salient objects. While the top-down attention utilizes the supervised learning to detect saliency. In recent years, more and more research tend to design deep neural networks with attention mechanisms to improve the accuracy of saliency detection. The design of deep attention neural network is inspired by human visual attention. The main goal is to enable the network to automatically capture the information that is critical to the target tasks and suppress irrelevant information, shift the attention from focusing on all to local. Currently various domain’s attention has been developed for saliency detection and semantic segmentation, such as the spatial attention module in convolution network, it generates a spatial attention map by utilizing the inter-spatial relationship of features; the channel attention module produces a attention by exploring the inter-channel relationship of features. All these well-designed attentions have been proven to be effective in improving the accuracy of saliency detection. This paper investigates the visual attention mechanism of salient object detection and applies it to digital histopathology image analysis for the detection and classification of breast cancer metastases. As shown in following contents, the main research contents include three parts: First, we studied the semantic attention mechanism and proposed a semantic attention approach to accurately localize the salient objects in complex scenarios. The proposed semantic attention uses Faster-RCNN to capture high-level deep features and replaces the last layer of Faster-RCNN by a FC layer and sigmoid function for visual saliency detection; it calculates proposals' attention probabilities by comparing their feature distances with the possible salient object. The proposed method introduces a re-weighting mechanism to reduce the influence of the complexity background, and a proposal selection mechanism to remove the background noise to obtain objects with accurate shape and contour. The simulation result shows that the semantic attention mechanism is robust to images with complex background due to the consideration of high-level object concept, the algorithm achieved outstanding performance among the salient object detection algorithms in the same period. Second, we designed a deep segmentation network (DSNet) for saliency object prediction. We explored a Pyramidal Attentional ASPP (PA-ASPP) module which can provide pixel level attention. DSNet extracts multi-level features with dilated ResNet-101 and the multiscale contextual information was locally weighted with the proposed PA-ASPP. The pyramid feature aggregation encodes the multi-level features from three different scales. This feature fusion incorporates neighboring scales of context features more precisely to produce better pixel-level attention. Finally, we use a scale-aware selection (SAS) module to locally weight multi-scale contextual features, capture important contexts of ASPP for the accurate and consistent dense prediction. The simulation results demonstrated that the proposed PA-ASPP is effective and can generate more coherent results. Besides, with the SAS, the model can adaptively capture the regions with different scales effectively. Finally, based on previous research on attentional mechanisms, we proposed a novel Deep Regional Metastases Segmentation (DRMS) framework for the detection and classification of breast cancer metastases. As we know, the digitalized whole slide image has high-resolution, usually has gigapixel, however the size of abnormal region is often relatively small, and most of the slide region are normal. The highly trained pathologists usually localize the regions of interest first in the whole slide, then perform precise examination in the selected regions. Even though the process is time-consuming and prone to miss diagnosis. Through observation and analysis, we believe that visual attention should be perfectly suited for the application of digital pathology image analysis. The integrated framework for WSI analysis can capture the granularity and variability of WSI, rich information from multi-grained pathological image. We first utilize the proposed attention mechanism based DSNet to detect the regional metastases in patch-level. Then, adopt the Density-Based Spatial Clustering of Applications with Noise (DBSCAN) to predict the whole metastases from individual slides. Finally, determine patient-level pN-stages by aggregating each individual slide-level prediction. In combination with the above techniques, the framework can make better use of the multi-grained information in histological lymph node section of whole-slice images. Experiments on large-scale clinical datasets (e.g., CAMELYON17) demonstrate that our method delivers advanced performance and provides consistent and accurate metastasis detection

Systematic literature review in cervical cancer staging using neural networks

Abstract Cervical cancer is the number two killer for women and the pap smear method is commonly used in the detection of the disease at an early stage. Cervical cancer is one of the biggest killers for many women globally. Several methods have been used to detect cancer during its early stages so that death figures can be reduced.  The detection of cancer in women has been a challenge and using the Pap smear test because of its slow and accuracy levels.   Scientifical neural networks are strong and reliable tools commonly used for building cancer prediction models for microarray data. Yearly, more than half a million women have been diagnosed with cervical cancer with 300 000 deaths worldwide. The deadly risk of more than a half million women with cervical cancer is the cause of the disease in most cases. Detection of cancer in developing and developed nations must invest a lot of funds in the detection of cancer to reduce mortalities worldwide. Cancer can be cured as long as it has been screened and detected at an early stage. This assists in giving ample time in the treatment of cancer.  The exact location of cancerous cells in thousands of cervical squamous epithelial cells can reduce doctors’ workloads of doctors and improve the accuracy of a cervical cancer diagnosis. Treatment of cancer depends on the disease extent at diagnosis and the availability of resources and might involve chemoradiation or hysterectomy. Conservatively, fertility-preserving surgical procedures are now standard for ladies with low risk at an early stage. Radiotherapy advancements like intensity-modulated radiotherapy have led to less treatment toxicity for ladies with locally advanced diseases. The study aims to review a systematic review of cervical cancer staging using neural networks. The study objectives are to analyse the effects of neural networks in the detection of cervical cancer, evaluation of the limitations in neural networking, assessment of other literature on neural networks and cervical cancer and the implementation of an outstanding method. The manual systematic review search was chosen for this study. The final review literature was 32 after the inclusion and exclusion criteria. The limitations of this study were the use of the manual search technique hence it is recommended that future studies adopted automatic and manual search methods. A systematic review is a very important aspect in the structuring of research studies as well as the gathering of relevant evidence and research findings.   Keywords:   Adenocarcinoma, Cell Carcinomas, Cervical Cancer Squamous, Deep learning, Neural Network, Transfer Learning

Deep Learning in Breast Cancer Imaging: A Decade of Progress and Future Directions

Breast cancer has reached the highest incidence rate worldwide among all malignancies since 2020. Breast imaging plays a significant role in early diagnosis and intervention to improve the outcome of breast cancer patients. In the past decade, deep learning has shown remarkable progress in breast cancer imaging analysis, holding great promise in interpreting the rich information and complex context of breast imaging modalities. Considering the rapid improvement in the deep learning technology and the increasing severity of breast cancer, it is critical to summarize past progress and identify future challenges to be addressed. In this paper, we provide an extensive survey of deep learning-based breast cancer imaging research, covering studies on mammogram, ultrasound, magnetic resonance imaging, and digital pathology images over the past decade. The major deep learning methods, publicly available datasets, and applications on imaging-based screening, diagnosis, treatment response prediction, and prognosis are described in detail. Drawn from the findings of this survey, we present a comprehensive discussion of the challenges and potential avenues for future research in deep learning-based breast cancer imaging.Comment: Survey, 41 page

Object Detection in medical imaging

A thesis submitted in partial fulfillment of the requirements for the degree of Doctor in Information Management, specialization in Information and Decision SystemsArtificial Intelligence, assisted by deep learning, has emerged in various fields of our society. These systems allow the automation and the improvement of several tasks, even surpassing, in some cases, human capability. Object detection methods are used nowadays in several areas, including medical imaging analysis. However, these methods are susceptible to errors, and there is a lack of a universally accepted method that can be applied across all types of applications with the needed precision in the medical field. Additionally, the application of object detectors in medical imaging analysis has yet to be thoroughly analyzed to achieve a richer understanding of the state of the art. To tackle these shortcomings, we present three studies with distinct goals. First, a quantitative and qualitative analysis of academic research was conducted to gather a perception of which object detectors are employed, the modality of medical imaging used, and the particular body parts under investigation. Secondly, we propose an optimized version of a widely used algorithm to overcome limitations commonly addressed in medical imaging by fine-tuning several hyperparameters. Thirdly, we develop a novel stacking approach to augment the precision of detections on medical imaging analysis. The findings show that despite the late arrival of object detection in medical imaging analysis, the number of publications has increased in recent years, demonstrating the significant potential for growth. Additionally, we establish that it is possible to address some constraints on the data through an exhaustive optimization of the algorithm. Finally, our last study highlights that there is still room for improvement in these advanced techniques, using, as an example, stacking approaches. The contributions of this dissertation are several, as it puts forward a deeper overview of the state-of-the-art applications of object detection algorithms in the medical field and presents strategies for addressing typical constraints in this area.A Inteligência Artificial, auxiliada pelo deep learning, tem emergido em diversas áreas da nossa sociedade. Estes sistemas permitem a automatização e a melhoria de diversas tarefas, superando mesmo, em alguns casos, a capacidade humana. Os métodos de detecção de objetos são utilizados atualmente em diversas áreas, inclusive na análise de imagens médicas. No entanto, esses métodos são suscetíveis a erros e falta um método universalmente aceite que possa ser aplicado em todos os tipos de aplicações com a precisão necessária na área médica. Além disso, a aplicação de detectores de objetos na análise de imagens médicas ainda precisa ser analisada minuciosamente para alcançar uma compreensão mais rica do estado da arte. Para enfrentar essas limitações, apresentamos três estudos com objetivos distintos. Inicialmente, uma análise quantitativa e qualitativa da pesquisa acadêmica foi realizada para obter uma percepção de quais detectores de objetos são empregues, a modalidade de imagem médica usada e as partes específicas do corpo sob investigação. Num segundo estudo, propomos uma versão otimizada de um algoritmo amplamente utilizado para superar limitações comumente abordadas em imagens médicas por meio do ajuste fino de vários hiperparâmetros. Em terceiro lugar, desenvolvemos uma nova abordagem de stacking para aumentar a precisão das detecções na análise de imagens médicas. Os resultados demostram que, apesar da chegada tardia da detecção de objetos na análise de imagens médicas, o número de publicações aumentou nos últimos anos, evidenciando o significativo potencial de crescimento. Adicionalmente, estabelecemos que é possível resolver algumas restrições nos dados por meio de uma otimização exaustiva do algoritmo. Finalmente, o nosso último estudo destaca que ainda há espaço para melhorias nessas técnicas avançadas, usando, como exemplo, abordagens de stacking. As contribuições desta dissertação são várias, apresentando uma visão geral em maior detalhe das aplicações de ponta dos algoritmos de detecção de objetos na área médica e apresenta estratégias para lidar com restrições típicas nesta área

EFFECTIVE BREAST CANCER DETECTION USING NOVEL DEEP LEARNING ALGORITHM

Ultrasound is one of the most common screening tools for breast cancer detection. However, the lack of qualified radiologists causes the diagnosis process to become a challenging task. Deep learning's promising achievement in various computer vision problems inspires us to apply the technology to medical image recognition problems. We propose a detection model based on the Rapid-CNN to detect breast cancer quickly and accurately. We conduct this experiment by collecting breast cancer datasets, pre-processing, training models, and evaluating the model performance. This model can detect breast cancer with bounding boxes based on the experiment result. In this model, it is possible to detect the bounding box that is more than what it should be, so we applied NMS  to eliminate the prediction of the bounding box that is less precise to increase accuracy