3,244 research outputs found
Brain Dynamics Based Automated Epileptic Seizure Detection
abstract: Approximately 1% of the world population suffers from epilepsy. Continuous long-term electroencephalographic (EEG) monitoring is the gold-standard for recording epileptic seizures and assisting in the diagnosis and treatment of patients with epilepsy. However, this process still requires that seizures are visually detected and marked by experienced and trained electroencephalographers. The motivation for the development of an automated seizure detection algorithm in this research was to assist physicians in such a laborious, time consuming and expensive task. Seizures in the EEG vary in duration (seconds to minutes), morphology and severity (clinical to subclinical, occurrence rate) within the same patient and across patients. The task of seizure detection is also made difficult due to the presence of movement and other recording artifacts. An early approach towards the development of automated seizure detection algorithms utilizing both EEG changes and clinical manifestations resulted to a sensitivity of 70-80% and 1 false detection per hour. Approaches based on artificial neural networks have improved the detection performance at the cost of algorithm's training. Measures of nonlinear dynamics, such as Lyapunov exponents, have been applied successfully to seizure prediction. Within the framework of this MS research, a seizure detection algorithm based on measures of linear and nonlinear dynamics, i.e., the adaptive short-term maximum Lyapunov exponent (ASTLmax) and the adaptive Teager energy (ATE) was developed and tested. The algorithm was tested on long-term (0.5-11.7 days) continuous EEG recordings from five patients (3 with intracranial and 2 with scalp EEG) and a total of 56 seizures, producing a mean sensitivity of 93% and mean specificity of 0.048 false positives per hour. The developed seizure detection algorithm is data-adaptive, training-free and patient-independent. It is expected that this algorithm will assist physicians in reducing the time spent on detecting seizures, lead to faster and more accurate diagnosis, better evaluation of treatment, and possibly to better treatments if it is incorporated on-line and real-time with advanced neuromodulation therapies for epilepsy.Dissertation/ThesisM.S. Electrical Engineering 201
A Hidden Markov Factor Analysis Framework for Seizure Detection in Epilepsy Patients
Approximately 1% of the world population suffers from epilepsy. Continuous long-term electroencephalographic (EEG) monitoring is the gold-standard for recording epileptic seizures and assisting in the diagnosis and treatment of patients with epilepsy. Detection of seizure from the recorded EEG is a laborious, time consuming and expensive task. In this study, we propose an automated seizure detection framework to assist electroencephalographers and physicians with identification of seizures in recorded EEG signals. In addition, an automated seizure detection algorithm can be used for treatment through automatic intervention during the seizure activity and on time triggering of the injection of a radiotracer to localize the seizure activity. In this study, we developed and tested a hidden Markov factor analysis (HMFA) framework for automated seizure detection based on different features such as total effective inflow which is calculated based on connectivity measures between different sites of the brain. The algorithm was tested on long-term (2.4-7.66 days) continuous sEEG recordings from three patients and a total of 16 seizures, producing a mean sensitivity of 96.3% across all seizures, a mean specificity of 3.47 false positives per hour, and a mean latency of 3.7 seconds form the actual seizure onset. The latency was negative for a few of the seizures which implies the proposed method detects the seizure prior to its onset. This is an indication that with some extension the proposed method is capable of seizure prediction
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Network Properties Revealed during Multi-Scale Calcium Imaging of Seizure Activity in Zebrafish.
Seizures are characterized by hypersynchronization of neuronal networks. Understanding these networks could provide a critical window for therapeutic control of recurrent seizure activity, i.e., epilepsy. However, imaging seizure networks has largely been limited to microcircuits in vitro or small "windows" in vivo. Here, we combine fast confocal imaging of genetically encoded calcium indicator (GCaMP)-expressing larval zebrafish with local field potential (LFP) recordings to study epileptiform events at whole-brain and single-neuron levels in vivo. Using an acute seizure model (pentylenetetrazole, PTZ), we reliably observed recurrent electrographic ictal-like events associated with generalized activation of all major brain regions and uncovered a well-preserved anterior-to-posterior seizure propagation pattern. We also examined brain-wide network synchronization and spatiotemporal patterns of neuronal activity in the optic tectum microcircuit. Brain-wide and single-neuronal level analysis of PTZ-exposed and 4-aminopyridine (4-AP)-exposed zebrafish revealed distinct network dynamics associated with seizure and non-seizure hyperexcitable states, respectively. Neuronal ensembles, comprised of coactive neurons, were also uncovered during interictal-like periods. Taken together, these results demonstrate that macro- and micro-network calcium motifs in zebrafish may provide a greater understanding of epilepsy
Topological biomarkers for real-time detection of epileptic seizures
Automated seizure detection is a fundamental problem in computational
neuroscience towards diagnosis and treatment's improvement of epileptic
disease. We propose a real-time computational method for automated tracking and
detection of epileptic seizures from raw neurophysiological recordings. Our
mechanism is based on the topological analysis of the sliding-window embedding
of the time series derived from simultaneously recorded channels. We extract
topological biomarkers from the signals via the computation of the persistent
homology of time-evolving topological spaces. Remarkably, the proposed
biomarkers robustly captures the change in the brain dynamics during the ictal
state. We apply our methods in different types of signals including scalp and
intracranial EEG and MEG, in patients during interictal and ictal states,
showing high accuracy in a range of clinical situations.Comment: 21 pages, 12 figure
A Novel Method for Epileptic Seizure Detection Using Coupled Hidden Markov Models
We propose a novel Coupled Hidden Markov Model to detect epileptic seizures
in multichannel electroencephalography (EEG) data. Our model defines a network
of seizure propagation paths to capture both the temporal and spatial evolution
of epileptic activity. To address the intractability introduced by the coupled
interactions, we derive a variational inference procedure to efficiently infer
the seizure evolution from spectral patterns in the EEG data. We validate our
model on EEG aquired under clinical conditions in the Epilepsy Monitoring Unit
of the Johns Hopkins Hospital. Using 5-fold cross validation, we demonstrate
that our model outperforms three baseline approaches which rely on a classical
detection framework. Our model also demonstrates the potential to localize
seizure onset zones in focal epilepsy.Comment: To appear in MICCAI 2018 Proceeding
SeizureNet: Multi-Spectral Deep Feature Learning for Seizure Type Classification
Automatic classification of epileptic seizure types in electroencephalograms
(EEGs) data can enable more precise diagnosis and efficient management of the
disease. This task is challenging due to factors such as low signal-to-noise
ratios, signal artefacts, high variance in seizure semiology among epileptic
patients, and limited availability of clinical data. To overcome these
challenges, in this paper, we present SeizureNet, a deep learning framework
which learns multi-spectral feature embeddings using an ensemble architecture
for cross-patient seizure type classification. We used the recently released
TUH EEG Seizure Corpus (V1.4.0 and V1.5.2) to evaluate the performance of
SeizureNet. Experiments show that SeizureNet can reach a weighted F1 score of
up to 0.94 for seizure-wise cross validation and 0.59 for patient-wise cross
validation for scalp EEG based multi-class seizure type classification. We also
show that the high-level feature embeddings learnt by SeizureNet considerably
improve the accuracy of smaller networks through knowledge distillation for
applications with low-memory constraints
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