Supervised machine learning based multi-task artificial intelligence classification of retinopathies

Artificial intelligence (AI) classification holds promise as a novel and affordable screening tool for clinical management of ocular diseases. Rural and underserved areas, which suffer from lack of access to experienced ophthalmologists may particularly benefit from this technology. Quantitative optical coherence tomography angiography (OCTA) imaging provides excellent capability to identify subtle vascular distortions, which are useful for classifying retinovascular diseases. However, application of AI for differentiation and classification of multiple eye diseases is not yet established. In this study, we demonstrate supervised machine learning based multi-task OCTA classification. We sought 1) to differentiate normal from diseased ocular conditions, 2) to differentiate different ocular disease conditions from each other, and 3) to stage the severity of each ocular condition. Quantitative OCTA features, including blood vessel tortuosity (BVT), blood vascular caliber (BVC), vessel perimeter index (VPI), blood vessel density (BVD), foveal avascular zone (FAZ) area (FAZ-A), and FAZ contour irregularity (FAZ-CI) were fully automatically extracted from the OCTA images. A stepwise backward elimination approach was employed to identify sensitive OCTA features and optimal-feature-combinations for the multi-task classification. For proof-of-concept demonstration, diabetic retinopathy (DR) and sickle cell retinopathy (SCR) were used to validate the supervised machine leaning classifier. The presented AI classification methodology is applicable and can be readily extended to other ocular diseases, holding promise to enable a mass-screening platform for clinical deployment and telemedicine.Comment: Supplemental material attached at the en

Detection of Hard Exudates in Retinal Fundus Images using Deep Learning

Diabetic Retinopathy (DR) is a retinal disorder that affects the people having diabetes mellitus for a long time (20 years). DR is one of the main reasons for the preventable blindness all over the world. If not detected early the patient may progress to severe stages of irreversible blindness. Lack of Ophthalmologists poses a serious problem for the growing diabetes patients. It is advised to develop an automated DR screening system to assist the Ophthalmologist in decision making. Hard exudates develop when DR is present. It is important to detect hard exudates in order to detect DR in an early stage. Research has been done to detect hard exudates using regular image processing techniques and Machine Learning techniques. Here, a deep learning algorithm has been presented in this paper that detects hard exudates in fundus images of the retina.Comment: 5 Pages, 3 figures, 2 tables, International Conference on Systems, Computation, Automation and Networking http://icscan.in

An Interpretable Machine Vision Approach to Human Activity Recognition using Photoplethysmograph Sensor Data

The current gold standard for human activity recognition (HAR) is based on the use of cameras. However, the poor scalability of camera systems renders them impractical in pursuit of the goal of wider adoption of HAR in mobile computing contexts. Consequently, researchers instead rely on wearable sensors and in particular inertial sensors. A particularly prevalent wearable is the smart watch which due to its integrated inertial and optical sensing capabilities holds great potential for realising better HAR in a non-obtrusive way. This paper seeks to simplify the wearable approach to HAR through determining if the wrist-mounted optical sensor alone typically found in a smartwatch or similar device can be used as a useful source of data for activity recognition. The approach has the potential to eliminate the need for the inertial sensing element which would in turn reduce the cost of and complexity of smartwatches and fitness trackers. This could potentially commoditise the hardware requirements for HAR while retaining the functionality of both heart rate monitoring and activity capture all from a single optical sensor. Our approach relies on the adoption of machine vision for activity recognition based on suitably scaled plots of the optical signals. We take this approach so as to produce classifications that are easily explainable and interpretable by non-technical users. More specifically, images of photoplethysmography signal time series are used to retrain the penultimate layer of a convolutional neural network which has initially been trained on the ImageNet database. We then use the 2048 dimensional features from the penultimate layer as input to a support vector machine. Results from the experiment yielded an average classification accuracy of 92.3%. This result outperforms that of an optical and inertial sensor combined (78%) and illustrates the capability of HAR systems using...Comment: 26th AIAI Irish Conference on Artificial Intelligence and Cognitive Scienc