96 research outputs found

    Graphene textile smart clothing for wearable cardiac monitoring

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    Wearable electronics is a rapidly growing field that recently started to introduce successful commercial products into the consumer electronics market. Employment of biopotential signals in wearable systems as either biofeedbacks or control commands are expected to revolutionize many technologies including point of care health monitoring systems, rehabilitation devices, human–computer/machine interfaces (HCI/HMIs), and brain–computer interfaces (BCIs). Since electrodes are regarded as a decisive part of such products, they have been studied for almost a decade now, resulting in the emergence of textile electrodes. This study reports on the synthesis and application of graphene nanotextiles for the development of wearable electrocardiography (ECG) sensors for personalized health monitoring applications. In this study, we show for the first time that the electrocardiogram was successfully obtained with graphene textiles placed on a single arm. The use of only one elastic armband, and an “all-textile-approach” facilitates seamless heart monitoring with maximum comfort to the wearer. The functionality of graphene textiles produced using dip coating and stencil printing techniques has been demonstrated by the non-invasive measurement of ECG signals, up to 98% excellent correlation with conventional pre-gelled, wet, silver/silver-chloride (Ag / AgCl) electrodes. Heart rate have been successfully determined with ECG signals obtained in different situations. The system-level integration and holistic design approach presented here will be effective for developing the latest technology in wearable heart monitoring devices

    Wearable smart textiles for long-term electrocardiography monitoring : a review

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    The continuous and long-term measurement and monitoring of physiological signals such as electrocardiography (ECG) are very important for the early detection and treatment of heart disorders at an early stage prior to a serious condition occurring. The increasing demand for the continuous monitoring of the ECG signal needs the rapid development of wearable electronic technology. During wearable ECG monitoring, the electrodes are the main components that affect the signal quality and comfort of the user. This review assesses the application of textile electrodes for ECG monitoring from the fundamentals to the latest developments and prospects for their future fate. The fabrication techniques of textile electrodes and their performance in terms of skin–electrode contact impedance, motion artifacts and signal quality are also reviewed and discussed. Textile electrodes can be fabricated by integrating thin metal fiber during the manufacturing stage of textile products or by coating textiles with conductive materials like metal inks, carbon mate-rials, or conductive polymers. The review also discusses how textile electrodes for ECG function via direct skin contact or via a non-contact capacitive coupling. Finally, the current intensive and promising research towards finding textile-based ECG electrodes with better comfort and signal quality in the fields of textile, material, medical and electrical engineering are presented as a perspective

    Textile Concentric Ring Electrodes for ECG Recording Based on Screen-Printing Technology

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    [EN] Among many of the electrode designs used in electrocardiography (ECG), concentric ring electrodes (CREs) are one of the most promising due to their enhanced spatial resolution. Their development has undergone a great push due to their use in recent years; however, they are not yet widely used in clinical practice. CRE implementation in textiles will lead to a low cost, flexible, comfortable, and robust electrode capable of detecting high spatial resolution ECG signals. A textile CRE set has been designed and developed using screen-printing technology. This is a mature technology in the textile industry and, therefore, does not require heavy investments. Inks employed as conductive elements have been silver and a conducting polymer (poly (3,4-ethylenedioxythiophene) polystyrene sulfonate; PEDOT: PSS). Conducting polymers have biocompatibility advantages, they can be used with flexible substrates, and they are available for several printing technologies. CREs implemented with both inks have been compared by analyzing their electric features and their performance in detecting ECG signals. The results reveal that silver CREs present a higher average thickness and slightly lower skin-electrode impedance than PEDOT: PSS CREs. As for ECG recordings with subjects at rest, both CREs allowed the uptake of bipolar concentric ECG signals (BC-ECG) with signal-to-noise ratios similar to that of conventional ECG recordings. Regarding the saturation and alterations of ECGs captured with textile CREs caused by intentional subject movements, silver CREs presented a more stable response (fewer saturations and alterations) than those of PEDOT: PSS. Moreover, BC-ECG signals provided higher spatial resolution compared to conventional ECG. This improved spatial resolution was manifested in the identification of P1 and P2 waves of atrial activity in most of the BC-ECG signals. It can be concluded that textile silver CREs are more suitable than those of PEDOT: PSS for obtaining BC-ECG records. These developed textile electrodes bring the use of CREs closer to the clinical environment.Grant from the Ministerio de Economia y Competitividad y del Fondo Europeo de Desarrollo Regional. DPI2015-68397-R (MINECO/FEDER). This work was also supported by the Spanish Government/FEDER funds (grant number MAT2015-64139-C4-3-R (MINECO/FEDER)).Lidon-Roger, JV.; Prats-Boluda, G.; Ye Lin, Y.; Garcia Casado, FJ.; Garcia-Breijo, E. (2018). Textile Concentric Ring Electrodes for ECG Recording Based on Screen-Printing Technology. Sensors. 18(1):300-314. https://doi.org/10.3390/s18010300S30031418

    Graphene textiles towards soft wearable interfaces for electroocular remote control of objects

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    Study of eye movements (EMs) and measurement of the resulting biopotentials, referred to as electrooculography (EOG), may find increasing use in applications within the domain of activity recognition, context awareness, mobile human-computer interaction (HCI) applications, and personalized medicine provided that the limitations of conventional “wet” electrodes are addressed. To overcome the limitations of conventional electrodes, this work, reports for the first time the use and characterization of graphene-based electroconductive textile electrodes for EOG acquisition using a custom-designed embedded eye tracker. This self-contained wearable device consists of a headband with integrated textile electrodes and a small, pocket-worn, battery-powered hardware with real-time signal processing which can stream data to a remote device over Bluetooth. The feasibility of the developed gel-free, flexible, dry textile electrodes was experimentally authenticated through side-by-side comparison with pre-gelled, wet, silver/silver chloride (Ag/AgCl) electrodes, where the simultaneously and asynchronous recorded signals displayed correlation of up to ~87% and ~91% respectively over durations reaching hundred seconds and repeated on several participants. Additionally, an automatic EM detection algorithm is developed and the performance of the graphene-embedded “all-textile” EM sensor and its application as a control element toward HCI is experimentally demonstrated. The excellent success rate ranging from 85% up to 100% for eleven different EM patterns demonstrates the applicability of the proposed algorithm in wearable EOG-based sensing and HCI applications with graphene textiles. The system-level integration and the holistic design approach presented herein which starts from fundamental materials level up to the architecture and algorithm stage is highlighted and will be instrumental to advance the state-of-the-art in wearable electronic devices based on sensing and processing of electrooculograms

    Conception, development and evaluation of polymer-based screen-printed textile electrodes for biopotential monitoring

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    Wearable technologies represent the new frontier of vital signs monitoring in different applications, from fitness to health. With the progressive miniaturization of the electronic components, enabling the implementation of portable and hand-held acquisition and recording devices, the research focus has shifted toward the development of effective and unobtrusive textile electrodes. This work deals with the study, development and characterization of organic-polymer-based electrodes for biopotentials. After an overview of the main materials and fabrication technologies presented so far in the scientific literature, the possibility to use these electrodes as an alternative to the Ag/AgCl disposable gelled electrodes usually adopted in clinical practice was tested. For this purpose, several textile electrode realization techniques were studied and optimized, in order to create electrodes with adequate features to detect two fundamental physiological signals: the electrocardiogram (ECG) and the electromyogram (EMG). The electrodes were obtained by depositing on the fabric the organic bio-compatible polymer poly(3,4-ethylenedioxythiophene) doped with poly(4-styrenesulfonate) (PEDOT:PSS) with three deposition procedures: dipcoating, ink-jet printing and screen printing. The physical\u2013chemical properties of the polymer solution were varied for each procedure to obtain an optimal and reproducible result. For what concerns the ECG signal, the research activity focused on screen-printed textile electrodes and their performance was first assessed by benchtop measurements and then by human trials. The first tests demonstrated that, by adding solid or liquid electrolytes the electrodes, the largest part of the characteristics required by the ANSI/AAMI EC12:2000 standard for gelled ECG electrodes can be achieved. Tests performed in different conditions showed that the skin contact impedance and the ECG morphological features are highly similar to those obtainable with disposable gelled Ag/AgCl electrodes (\u3c1 > 0.99). A trial with ten subjects revealed also the capability of the proposed electrodes to accurately capture with clinical instruments an ECG morphology with performance comparable to off-the-shelf disposable electrodes. Furthermore, the proposed textile electrodes preserve their electrical properties and functionality even after several mild washing cycles, while they suffered physical stretching. Similar tests were performed on screen-printed textile electrodes fabricated in two different sizes to test them as EMG sensors, with and without electrolytes. After a series of controlled acquisitions performed by electro-stimulating the muscles in order to analyze the waveform morphologu of the M-wave, the statistical analysis showed a high similarity in terms of rms of the noise and electrode-skin impedance between conventional and textile electrodes with the addition of solid hydrogel and saline solution. Furthermore, the M-wave recorded on the tibialis anterior muscle during the stimulation of the peroneal nerve was comparatively analyzed between conventional and textile electrodes. The comparison provided an R2 value higher than 97% in all measurement conditions. These results opened their use in smart garments for real application scenarios and for this purpose were developed a couple of smart shirts able to detect the EGC and the EMG signal. The results indicated that this approach could be adopted in the future for the development of smart garments able to comfortably detect physiological signals

    Neurotechnology : design of a semi-dry electroencephalography electrode

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    In the research of the brain, the most complex organ of the human body, its function can be studied through the analysis of Evoked Potentials (EP). This evoked activity can be reproduced in a diverse way and recorded with an Electroencephalogram (EEG). To register the different types of brainwaves, the electrodes have a very important role. The first part of the thesis presents an extended literature review of the different types of EEG electrodes available on the market, out-standing publications and patents. A semi-dry porous ceramic electrode prototype was proposed to register EEG signals. The sensor model was developed with the aim of improving the accuracy of the actual sensors, checking many current designs, and improving artefact attenuation. It was not possible to test this design for lack of time and resources. Additionally, an EEG headset was also studied and developed to place the in-built-reservoir sensors according to the 10-20 placement system. Moreover, on the second part of this project, a skin-electrode contact impedance protocol was presented and tested with four different dry electrode materials in a diverse frequency range. The protocol used, which is a combination of some techniques already employed, has differentiated and separated the potential external hazards that can provoke an impact on bioimpedance measurements. The results obtained allow to determine the degree of utility of an electrode and how much time was required and recommended to place the electrodes before its optimal impedance acquisition.Outgoin

    Micromachined three-dimensional electrode arrays for in-vitro and in-vivo electrogenic cellular networks

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    This dissertation presents an investigation of micromachined three-dimensional microelectrode arrays (3-D MEAs) targeted toward in-vitro and in-vivo biomedical applications. Current 3-D MEAs are predominantly silicon-based, fabricated in a planar fashion, and are assembled to achieve a true 3-D form: a technique that cannot be extended to micro-manufacturing. The integrated 3-D MEAs developed in this work are polymer-based and thus offer potential for large-scale, high volume manufacturing. Two different techniques are developed for microfabrication of these MEAs - laser micromachining of a conformally deposited polymer on a non-planar surface to create 3-D molds for metal electrodeposition; and metal transfer micromolding, where functional metal layers are transferred from one polymer to another during the process of micromolding thus eliminating the need for complex and non-repeatable 3-D lithography processes. In-vitro and in-vivo 3-D MEAs are microfabricated using these techniques and are packaged utilizing Printed Circuit Boards (PCB) or other low-cost manufacturing techniques. To demonstrate in-vitro applications, growth of 3-D co-cultures of neurons/astrocytes and tissue-slice electrophysiology with brain tissue of rat pups were implemented. To demonstrate in-vivo application, measurements of nerve conduction were implemented. Microelectrode impedance models, noise models and various process models were evaluated. The results confirmed biocompatibility of the polymers involved, acceptable impedance range and noise of the microelectrodes, and potential to improve upon an archaic clinical diagnostic application utilizing these 3-D MEAs.Ph.D.Committee Chair: Mark G. Allen; Committee Member: Elliot L. Chaikof; Committee Member: Ionnis (John) Papapolymerou; Committee Member: Maysam Ghovanloo; Committee Member: Oliver Bran

    Time Synchronization in Multimodal Wireless Cyber-Physical Systems: A Wearable Biopotential Acquisition and Collaborative Brain-Computer Interface Paradigm

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    Die Forschung zu Brain-Computer Interface (BCI) hat in den letzten drei Jahren riesige Fortschritte gemacht, nicht nur im Bereich der menschlich gesteuerten Roboter, der Steuerung von Prothesen, des Interpretierens von Wörtern, der Kommunikation in einer Virtual Reality Umgebung oder der Computerspiele, sondern auch in der kognitiven Neurologie. Patienten, die unter enormen motorischen Dysfunktionen leiden (letztes Stadium Amyotrophe Lateralsklerose) könnten solch ein BCI System als alternatives Medium zur Kommunikation durch die eigene GehirnaktivitĂ€t nutzen. Neuste Studien zeigen, dass die Verwendung dieses BCI Systems in einem Gruppenexperiment helfen kann die menschliche Entscheidungstreffung deutlich zu verbessern. Dies ist ein neues Feld des BCI, nĂ€mlich das Collaborative BCI. Einerseits erfordert die DurchfĂŒhrung solch eines Gruppenexperiments drahtlose Hochleistungs-EEG Systeme, basierend auf BCI, welches kostengĂŒnstig und tragbar sein sollte und Langzeit-Monitoring hochwertiger EEG Daten sicherstellt. Andererseits ist es erforderlich, eine Zeitsynchronisierung zwischen den einzelnen BCI Systemen einzusetzen, damit diese fĂŒr ein Gruppenexperiment zum Einsatz kommen können. Diese Herausforderungen setzten die Grundlage dieser Doktorarbeit. In dieser Arbeit wurde ein neuartiges, nicht invasives, modulares, biopotentiales Messsystem entwickelt: Dieses kann Breitband (0.5 Hz–150 Hz) Biopotentiale ableiten, bestehend aus Elektromyographie (EMG), Elektrokardiografie (EKG), Elektroencephalografie (EEG), wurde insgesamt bezeichnet als ExG bzw. das Messsystem als ExG-System benannt. Die ModularitĂ€t des ExG-Systems erlaubt 8 bis hin zu 256 KanĂ€le zu konfigurieren, je nach Anforderung, ob in einen textilen Schlauch eingekapselt zur Erfassung von EMG Signalen, in eine textilen Weste zur Erfassung von ECG Signalen oder in eine textilen Kappe zur Erfassung von EEG Signalen. Der Einbau des ExG-Systems in eine Kappe wurde ebenfalls im Rahmen der Arbeit entwickelt. Der letzte Schritt des ExG-Systems zeigt niedriges Eingangsrauschen von 7 ”Vvon-Spitze-zu-Spitze und benötigt 41 mW/Kanal der Datenaufnahme im aktiven Zustand. Ein WiFi-Modul wurde fĂŒr eine drahtlose DatenĂŒbertragung an einen ferngesteuerten PC in das ExG-System eingebaut. Um mit dem entwickelte System BCI Anwendungen zu ermöglichen, wurde ein akustisch und visuell evozierter Potenzialstimulator (SSVEP/AEP Stimulator) entwickelt. In eben diesem wurde ein Rasperry Pi als Zentralrechner benutzt und ein Bash basiertes Player-Skript iii einprogrammiert, das Mediadaten (Video, Audio, Ton) aus der Angabe einer Lookup Tabelle (LUT) in ihr Linux Betriebssystem spielt. Im Rahmen der Arbeit wurde eine Zeitsynchronisierung an einigen dieser ExG-Systeme mit Hilfe von einer eingebetteten Hardware/Softwarelösung durchgefĂŒhrt. Die Hardwareteile bestehen aus einigen Leiterplatten, nĂ€mlich Sync Modulen mit einem Quarzoszillator, einem Mikrocontroller und einem Funkmodul (Hierbei Bluetooth 4.0). Eines von diesen ist das Sync-Addon, das mit jedem Messsystem (z.B. ExG-System) das zu synchronisieren ist, angeschlossen wird. Das andere bezeichnet man als Sync-Center, das an die Datenverarbeitungsrechner angehĂ€ngt wird. Das Softwareteil ĂŒbernimmt den Zeitsynchronisierungsmechanismus mit Hilfe eines funkbasierten Protokolls. Im Rahmen der Arbeit wurde ein neues energieeffizientes pairwise broadcast Zeitsynchronisationsprotokoll (PBS), welches nur theoretisch vorgestellt wurde, experimentell verifiziert. Außerdem wurde es mit anderen bestehenden Zeitsynchronisationsprotokollen auf dem aktuellen Stand der Technik evaluiert, basierend auf den Ergebnissen der gleichen Hardwareebene. In der letzten Iteration der Sync-Module wurde ein durchschnittlicher Synchronisationsfehler von 2 ms, den Konfidenzintervall von 95% berĂŒcksichtigend, erlangt. Da fĂŒr Collaborative BCI, P300, ein Ereignis bezogenes Potenzial mit dem Auslöseimpuls, der 300−500 ms nach dem Vorgang eintritt, eingestellt wurde, ist die erreichte Synchronisationsgenauigkeit genĂŒgend, um solch ein Experiment durchzufĂŒhren.Brain-computer interface (BCI) has experienced the last three decades tremendous technological advances not only in the field of human controller robotics, or in controlling prosthesis, or in spelling words, or in interacting with a virtual reality environment, or in gaming but also in cognitive neuroscience. Patients suffering from severe motoric dysfunction (e.g. late stage of Amyotrophic Lateral Sclerosis) may utilise such a BCI system as an alternative medium of communication by mental activity. Recently studies have shown that usage of such BCI in a group experiment can help to improve human decision making. This is a new field of BCI, namely collaborative BCI. On one hand, performing such group experiments require wireless, high density EEG system based BCI which should be low-cost, wearable and provide long time monitoring of good quality EEG data. On the other hand time synchronization is required to be established among a group of BCI systems if they are employed for such a group experiments. These drawbacks set the foundation of this thesis work. In this work a novel non-invasive modular biopotential measurement system which can acquire wideband (0.15 Hz–200 Hz) biopotential signals consisting Electromyography (EMG), Electrocardiography (ECG), Electroencephalography (EEG) together called ExG, following ExG-system was designed. The modularity of the ExG-system allows it to be configured from 8 up to 256 channels according to the requirement if it’s to be encapsulated in a textile sleeve for recording of EMG signals, or in a textile vest for recording of ECG signals, or in a textile cap for recording of EEG signals. The assembly of the ExG-system in cap was also developed during the scope of the work. The final iteration of the ExG-system exhibits low input noise of 7 ”Vpeak-to-peak and require 41 mW/channel of data recording in active state. A WiFi module was embedded into the ExG-system for wireless data transmission to a remote PC. To enable the developed system for BCI applications a steady-state visually/auditory evoked potential stimulator (SSVEP/AEP stimulator) incorporating a Raspberry Pi as a main computer and a bash based player script which plays media data (video, pictures, sound) as defined in a lookup table in the Linux operating system of it. Within the scope of the work time synchronization among a group of such ExG-systems was further realized with the help of an embedded hardware/software solution. The hardware part consists of two different PCB sync modules that are incorporated with a crystal oscillator a microcontroller, a radio module (in this case Bluetooth 4.0). One of them is called the v sync-addon which is to be attached to each of the measurement systems (e.g. ExG-system) that are to be synchronized and the sync-center which is to be attached to the remote PC. On the software part, a wireless time synchronization protocol exchanging timing information among the sync-center and sync-addons must establish tight time synchronization between the ExG-system. Within the framework of this work, a novel time synchronization protocol energy efficient pairwise broadcast synchronization protocol (PBS) that was only theoretically proposed before but not evaluated on real hardware was experimentally evaluated with the developed sync modules. Moreover a benchmarking with other state-of-the-art existing time synchronization protocols based on the results from same hardware platform were drawn. In the final iteration of sync modules an average synchronization error of 2 ms was achieved considering the 95% of confidence interval. Since for collaborative BCI, P300, an event related potential was triggered with the stimuli that occur 300−500 ms after the event, the achieved synchronization accuracy is sufficient to conduct such experiments

    Southwest Research Institute assistance to NASA in biomedical areas of the technology utilization program

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    The activities are reported of the NASA Biomedical Applications Team at Southwest Research Institute between 25 August, 1972 and 15 November, 1973. The program background and methodology are discussed along with the technology applications, and biomedical community impacts

    Wireless tools for neuromodulation

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    Epilepsy is a spectrum of diseases characterized by recurrent seizures. It is estimated that 50 million individuals worldwide are affected and 30% of cases are medically refractory or drug resistant. Vagus nerve stimulation (VNS) and deep brain stimulation (DBS) are the only FDA approved device based therapies. Neither therapy offers complete seizure freedom in a majority of users. Novel methodologies are needed to better understand mechanisms and chronic nature of epilepsy. Most tools for neuromodulation in rodents are tethered. The few wireless devices use batteries or are inductively powered. The tether restricts movement, limits behavioral tests, and increases the risk of infection. Batteries are large and heavy with a limited lifetime. Inductive powering suffers from rapid efficiency drops due to alignment mismatches and increased distances. Miniature wireless tools that offer behavioral freedom, data acquisition, and stimulation are needed. This dissertation presents a platform of electrical, optical and radiofrequency (RF) technologies for device based neuromodulation. The platform can be configured with features including: two channels differential recording, one channel electrical stimulation, and one channel optical stimulation. Typical device operation consumes less than 4 mW. The analog front end has a bandwidth of 0.7 Hz - 1 kHz and a gain of 60 dB, and the constant current driver provides biphasic electrical stimulation. For use with optogenetics, the deep brain optical stimulation module provides 27 mW/mm2 of blue light (473 nm) with 21.01 mA. Pairing of stimulating and recording technologies allows closed-loop operation. A wireless powering cage is designed using the resonantly coupled filter energy transfer (RCFET) methodology. RF energy is coupled through magnetic resonance. The cage has a PTE ranging from 1.8-6.28% for a volume of 11 x 11 x 11 in3. This is sufficient to chronically house subjects. The technologies are validated through various in vivo preparations. The tools are designed to study epilepsy, SUDEP, and urinary incontinence but can be configured for other studies. The broad application of these technologies can enable the scientific community to better study chronic diseases and closed-loop therapies
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