7 research outputs found

    Experiences of Engineering Grid-Based Medical Software

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    Objectives: Grid-based technologies are emerging as potential solutions for managing and collaborating distributed resources in the biomedical domain. Few examples exist, however, of successful implementations of Grid-enabled medical systems and even fewer have been deployed for evaluation in practice. The objective of this paper is to evaluate the use in clinical practice of a Grid-based imaging prototype and to establish directions for engineering future medical Grid developments and their subsequent deployment. Method: The MammoGrid project has deployed a prototype system for clinicians using the Grid as its information infrastructure. To assist in the specification of the system requirements (and for the first time in healthgrid applications), use-case modelling has been carried out in close collaboration with clinicians and radiologists who had no prior experience of this modelling technique. A critical qualitative and, where possible, quantitative analysis of the MammoGrid prototype is presented leading to a set of recommendations from the delivery of the first deployed Grid-based medical imaging application. Results: We report critically on the application of software engineering techniques in the specification and implementation of the MammoGrid project and show that use-case modelling is a suitable vehicle for representing medical requirements and for communicating effectively with the clinical community. This paper also discusses the practical advantages and limitations of applying the Grid to real-life clinical applications and presents the consequent lessons learned.Comment: 18 pages, 2 tables, 5 figures. In press International Journal of Medical Informatics. Elsevier publisher

    Agent-based management of clinical guidelines

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    Les guies de pràctica clínica (GPC) contenen un conjunt d'accions i dades que ajuden a un metge a prendre decisions sobre el diagnòstic, tractament o qualsevol altre procediment a un pacient i sobre una determinada malaltia. És conegut que l'adopció d'aquestes guies en la vida diària pot millorar l'assistència mèdica als pacients, pel fet que s'estandarditzen les pràctiques. Sistemes computeritzats que utilitzen GPC poden constituir part de sistemes d'ajut a la presa de decisions més complexos amb la finalitat de proporcionar el coneixement adequat a la persona adequada, en un format correcte i en el moment precís. L'automatització de l'execució de les GPC és el primer pas per la seva implantació en els centres mèdics.Per aconseguir aquesta implantació final, hi ha diferents passos que cal solucionar com per exemple, l'adquisició i representació de les GPC, la seva verificació formal, i finalment la seva execució. Aquesta Tesi està dirigida en l'execució de GPC i proposa la implementació d'un sistema multi-agent. En aquest sistema els diferents actors dels centres mèdics coordinen les seves activitats seguint un pla global determinat per una GPC. Un dels principals problemes de qualsevol sistema que treballa en l'àmbit mèdic és el tractament del coneixement. En aquest cas s'han hagut de tractar termes mèdics i organitzatius, que s'ha resolt amb la implementació de diferents ontologies. La separació de la representació del coneixement del seu ús és intencionada i permet que el sistema d'execució de GPC sigui fàcilment adaptable a les circumstàncies concretes dels centres, on varien el personal i els recursos disponibles.En paral·lel a l'execució de GPC, el sistema proposat manega preferències del pacient per tal d'implementar serveis adaptats al pacient. En aquesta àrea concretament, a) s'han definit un conjunt de criteris, b) aquesta informació forma part del perfil de l'usuari i serveix per ordenar les propostes que el sistema li proposa, i c) un algoritme no supervisat d'aprenentatge permet adaptar les preferències del pacient segons triï.Finalment, algunes idees d'aquesta Tesi actualment s'estan aplicant en dos projectes de recerca. Per una banda, l'execució distribuïda de GPC, i per altra banda, la representació del coneixement mèdic i organitzatiu utilitzant ontologies.Clinical guidelines (CGs) contain a set of directions or principles to assist the health care practitioner with patient care decisions about appropriate diagnostic, therapeutic, or other clinical procedures for specific clinical circumstances. It is widely accepted that the adoption of guideline-execution engines in daily practice would improve the patient care, by standardising the care procedures. Guideline-based systems can constitute part of a knowledge-based decision support system in order to deliver the right knowledge to the right people in the right form at the right time. The automation of the guideline execution process is a basic step towards its widespread use in medical centres.To achieve this general goal, different topics should be tackled, such as the acquisition of clinical guidelines, its formal verification, and finally its execution. This dissertation focuses on the execution of CGs and proposes the implementation of an agent-based platform in which the actors involved in health care coordinate their activities to perform the complex task of guideline enactment. The management of medical and organizational knowledge, and the formal representation of the CGs, are two knowledge-related topics addressed in this dissertation and tackled through the design of several application ontologies. The separation of the knowledge from its use is fully intentioned, and allows the CG execution engine to be easily customisable to different medical centres with varying personnel and resources.In parallel with the execution of CGs, the system handles citizen's preferences and uses them to implement patient-centred services. With respect this issue, the following tasks have been developed: a) definition of the user's criteria, b) use of the patient's profile to rank the alternatives presented to him, c) implementation of an unsupervised learning method to adapt dynamically and automatically the user's profile.Finally, several ideas of this dissertation are being directly applied in two ongoing funded research projects, including the agent-based execution of CGs and the ontological management of medical and organizational knowledge

    Implementasi deteksi serangan epilepsi dari data rekaman EEG menggunakan Weighted Permutation Entropy dan Support Vector Machine

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    Epilepsi merupakan gangguan neurologis jangka panjang yang ditandai dengan serangan-serangan epileptik. Serangan epileptik dapat terjadi dalam waktu singkat hingga guncangan kuat dalam waktu yang lama. Epilepsi adalah penyakit yang cenderung terjadi secara berulang dan tidak dapat disembuhkan, namun serangan-serangan epileptik yang terjadi dapat dikontrol melalui pengobatan. Pada tugas akhir ini, data rekaman electroencephalogram (EEG) dibagi menjadi beberapa window menggunakan segmentasi atau dekomposisi. Proses selanjutnya adalah mengekstraksi setiap window dengan menggunakan Weighted Permutation Entropy yang menghasilkan satu fitur setiap window. Uji coba fitur menggunakan k-fold cross-validation dengan membagi data menjadi data training dan data testing. Selanjutnya data diklasifikasi menggunakan Support Vector Machine. Data rekaman EEG yang digunakan untuk pengujian ini berasal dari ''Klinik für Epileptologie, Universität Bonn” yang diperoleh secara online yang berjumlah 500 data. Data ini terdiri dari serangan epilepsi (set S) dan bukan serangan epilepsi (set Z, N, O, F) yang masing-masing set terdiri dari 100 data. Set Z direkam dari lima orang sehat dengan mata tertutup dan set O direkam dari lima orang sehat mata terbuka. Set F direkam dari penderita epilepsi yang tidak mengalami serangan di hippocampal formation, set N direkam dari penderita epilepsi yang tidak mengalami sernagan di epileptogenic zone, dan set S direkam dari penderita epilepsi ketika terjadi serangan di epileptogenic zone. Uji coba dilakukan pada data set S digabung dengan setiap set lain. Sehingga data yang digunakan sebanyak 200 data rekaman EEG untuk setiap uji coba. Berdasarkan uji coba, metode tersebut menghasilkan akurasi rata-rata sebesar 91,88%. ================================================================= Epilepsy is a long-term neurological disorder characterized by epileptic seizures. Epileptic seizures can occur in a short period of time until a strong shock for a long time. Epilepsy is a disease that tends to occur repeatedly and cannot be healed, but epileptic seizures that occur can be controlled through treatment. In this undergraduate thesis, the electroencephalogram (EEG) record data will be divided into several windows using segmentation or decomposition. The next process is to extract each window by using a Weighted Permutation Entropy that produces a feature of each window. The feature will be tested using k-fold cross-validation by dividing data into training and testing data. Furthermore data is classified using Support Vector Machine. The EEG record data used for testing in this experiment was taken from the online data collected by 500 online '' Clinical für Epileptologie, Universität Bonn '. This data consists of epileptic seizure (set S) and seizure free (set Z, N, O, F) each of which consists of 100 data. Set Z was recorded from five healthy people when eyes are closed and set O recorded from five healthy people when eyes are opened. Set F was recorded from five epilepsy patients during seizure free in hippocampal formation, N sets was recorded from five epilepsy patients during seizure free in epileptogenic zone, and set S was recorded from five epilepsy patients during seizure in epileptogenic zone. The trial test use set S combined with every other set. So the data used are 200 EEG record data for each test. Based on the trials, the proposed method above gave an average accuracy of 91.88%

    AIUCD2018 - Book of Abstracts

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    Questo volume raccoglie gli abstract dei paper presentati al Settimo Convegno Annuale AIUCD 2018 (Bari, 31 gennaio – 2 febbraio 2018) dal titolo "Patrimoni culturali nell’era digitale. Memorie, culture umanistiche e tecnologia" (Cultural Heritage in the Digital Age. Memory, Humanities and Technologies). Gli abstract pubblicati in questo volume hanno ottenuto il parere favorevole da parte di valutatori esperti della materia, attraverso un processo di revisione anonima mediante double-blind peer review sotto la responsabilità del Comitato Scientifico di AIUCD. Il programma della conferenza AIUCD 2018 è disponibile online all'indirizzo http://www.aiucd2018.uniba.it/

    AIUCD2018 - Book of Abstracts

    Get PDF
    Questo volume raccoglie gli abstract dei paper presentati al Settimo Convegno Annuale AIUCD 2018 (Bari, 31 gennaio – 2 febbraio 2018) dal titolo "Patrimoni culturali nell’era digitale. Memorie, culture umanistiche e tecnologia" (Cultural Heritage in the Digital Age. Memory, Humanities and Technologies). Gli abstract pubblicati in questo volume hanno ottenuto il parere favorevole da parte di valutatori esperti della materia, attraverso un processo di revisione anonima mediante double-blind peer review sotto la responsabilità del Comitato Scientifico di AIUCD. Il programma della conferenza AIUCD 2018 è disponibile online all'indirizzo http://www.aiucd2018.uniba.it/
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