19,431 research outputs found
Complex-Dynamical Extension of the Fractal Paradigm and Its Applications in Life Sciences
Complex-dynamical fractal is a hierarchy of permanently, chaotically changing versions of system structure, obtained as the unreduced, causally probabilistic general solution of arbitrary interaction problem (physics/0305119, physics/9806002). Intrinsic creativity of this extension of usual fractality determines its exponentially high operation efficiency, which underlies many specific functions of living systems, such as autonomous adaptability, "purposeful" development, intelligence and consciousness (at higher complexity levels). We outline in more detail genetic applications of complex-dynamic fractality, demonstrate the dominating role of genome interactions, and show that further progressive development of genetic research, as well as other life-science applications, should be based on the dynamically fractal structure analysis of interaction processes involved. The obtained complex-dynamical fractal of a living organism specifies the intrinsic unification of its interaction dynamics at all levels, from genome structure to higher brain functions. We finally summarise the obtained extension of mathematical concepts and approaches closely related to their biological applications
Modeling and evolving biochemical networks: insights into communication and computation from the biological domain
This paper is concerned with the modeling and evolving
of Cell Signaling Networks (CSNs) in silico. CSNs are
complex biochemical networks responsible for the coordination of cellular activities. We examine the possibility to computationally evolve and simulate Artificial Cell Signaling Networks (ACSNs) by means of Evolutionary Computation techniques. From a practical point of view, realizing and evolving ACSNs may provide novel computational paradigms for a variety of application areas. For example, understanding some inherent properties of CSNs such as crosstalk may be of interest: A potential benefit of engineering crosstalking systems is that it allows the modification of a specific process according to the state of other processes in the system. This is clearly necessary in order to achieve complex control tasks. This work may also contribute to the biological understanding of the origins and evolution of real CSNs. An introduction to CSNs is first
provided, in which we describe the potential applications
of modeling and evolving these biochemical networks in
silico. We then review the different classes of techniques to model CSNs, this is followed by a presentation of two alternative approaches employed to evolve CSNs within the
ESIGNET project. Results obtained with these methods
are summarized and discussed
Improving Receiver Performance of Diffusive Molecular Communication with Enzymes
This paper studies the mitigation of intersymbol interference in a diffusive
molecular communication system using enzymes that freely diffuse in the
propagation environment. The enzymes form reaction intermediates with
information molecules and then degrade them so that they cannot interfere with
future transmissions. A lower bound expression on the expected number of
molecules measured at the receiver is derived. A simple binary receiver
detection scheme is proposed where the number of observed molecules is sampled
at the time when the maximum number of molecules is expected. Insight is also
provided into the selection of an appropriate bit interval. The expected bit
error probability is derived as a function of the current and all previously
transmitted bits. Simulation results show the accuracy of the bit error
probability expression and the improvement in communication performance by
having active enzymes present.Comment: 13 pages, 8 figures, 1 table. To appear in IEEE Transactions on
Nanobioscience (submitted January 22, 2013; minor revision October 16, 2013;
accepted December 4, 2013
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