Big data driven oriented graph theory aided tagSNPs selection for genetic precision therapy

Recently, the world-wide human genome-related projects have been vigorously launched and implemented. Gene-sequencing techniques play a critical role in disease diagnosis, prediction, and population stratification relying on efficiently mining genetic features in the gene pool. Exploring the association between the sites of the genetic mutation and the disease-based population classification becomes a hot topic, which beneficially supports disease diagnosis and treatment on the molecular level. However, there are numerous variable sites even on a single chromosome in the human gene pool, and hence, the traditional classifiers are not able to dig out all single nucleotide polymorphism (SNP) sites without clearly excavating the characteristic SNP sites, termed tagSNPs, in SNP clusters. By applying big data mining techniques, in this paper, we, first of all, propose a principal component analysis-based algorithm for reducing the gene data dimension in order to cluster SNP sites in the low-dimensional space. Moreover, an oriented graph theory-based tagSNPs selection algorithm is designed. Finally, relying on the real-world 1000 Genomes Project dataset, we can achieve fewer tagSNPs than the traditional methods by invoking the complete process of our designed SNP classifier.</p

Genetics and Genomics of Pulmonary Arterial Hypertension

Pulmonary arterial hypertension is a severe and progressive disorder affecting the blood vessels in the lungs. Typically, symptoms first appear at around 30–40 years of age and, without treatment, can lead to fatal heart disease within a few years. Genetic studies over the past decade have identified numerous genes that contribute to disease progression but, for many sufferers, the underlying genetic cause remains elusive. The collection of reviews and original research articles contained within this book provide an overview of recent advancements in understanding the genetic risk factors for pulmonary arterial hypertension. We further examine the emerging interplay between genetic variants and clinical outcomes, providing a framework for new treatments and improved patient care

Highlights CNR 2009-2010

The 2009-2010 edition of CNR.it (the CNR Highlights) includes more than 200 scientific papers. Conceived and written in English to present to the international public the dynamic and multi-sided reality of the largest research organization in Italy, this review is a partial but significant collection of works carried out by CNR researchers and published on the main scientific journals. Articles have been selected on the basis of their impact factors among the 14.000 or so articles produced in the last two years, to present our best image to the world. The present one is only the second of the CNR Highlights, after a first one dedicated to the Italian public, but the series represent already a must for our researchers, to promote their works along best-practice lines followed in research organizations worldwide. In the present edition, with a more catchy new look, articles, images and scientific popularizations provide a broad outlook of the activities of CNR, reporting, side by side with research articles, about technology transfer and scientific support activities to national and local institutions. The 2009-2010 Highlights are divided into four sections, similarly to the previous edition. However, as the reader looks through the pages, the interdisciplinary nature of the works will not pass unnoticed, interdisciplinarity being the peculiar feature of CNR, an organization in which the different disciplines find a fertile breeding ground to communicate and share their different knowledge

Glioma

The tittle 'Glioma - Exploring Its Biology and Practical Relevance' is indicative of its content. This volume contains 21 chapters basically intended to explore glioma biology and discussing the experimental model systems for the purpose. It is hoped that the present volume will provide supportive and relevant awareness and understanding on the fundamental advances of the subject to the professionals from any sphere interested about glioma

Activity Report in “Highlights 2009/2010”

The 2009-2010 edition of CNR.it (the CNR Highlights) includes more than 200 scientific papers. Conceived and written in English to present to the international public the dynamic and multi-sided reality of the largest research organization in Italy, this review is a partial but significant collection of works carried out by CNR researchers and published on the main scientific journals. In the present edition, with a more catchy new look, articles, images and scientific popularizations provide a broad outlook of the activities of CNR, reporting, side by side with research articles, about technology transfer and scientific support activities to national and local institutions. The 2009-2010 Highlights are divided into four sections, similarly to the previous edition. However, as the reader looks through the pages, the interdisciplinary nature of the works will not pass unnoticed, interdisciplinarity being the peculiar feature of CNR, an organization in which the different disciplines find a fertile breeding ground to communicate and share their different knowledge