171,133 research outputs found

    Retrospective harm benefit analysis of pre-clinical animal research for six treatment interventions

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    The harm benefit analysis (HBA) is the cornerstone of animal research regulation and is considered to be a key ethical safeguard for animals. The HBA involves weighing the anticipated benefits of animal research against its predicted harms to animals but there are doubts about how objective and accountable this process is.i. To explore the harms to animals involved in pre-clinical animal studies and to assess these against the benefits for humans accruing from these studies; ii. To test the feasibility of conducting this type of retrospective HBA.Data on harms were systematically extracted from a sample of pre-clinical animal studies whose clinical relevance had already been investigated by comparing systematic reviews of the animal studies with systematic reviews of human studies for the same interventions (antifibrinolytics for haemorrhage, bisphosphonates for osteoporosis, corticosteroids for brain injury, Tirilazad for stroke, antenatal corticosteroids for neonatal respiratory distress and thrombolytics for stroke). Clinical relevance was also explored in terms of current clinical practice. Harms were categorised for severity using an expert panel. The quality of the research and its impact were considered. Bateson's Cube was used to conduct the HBA.The most common assessment of animal harms by the expert panel was 'severe'. Reported use of analgesia was rare and some animals (including most neonates) endured significant procedures with no, or only light, anaesthesia reported. Some animals suffered iatrogenic harms. Many were kept alive for long periods post-experimentally but only 1% of studies reported post-operative care. A third of studies reported that some animals died prior to endpoints. All the studies were of poor quality. Having weighed the actual harms to animals against the actual clinical benefits accruing from these studies, and taking into account the quality of the research and its impact, less than 7% of the studies were permissible according to Bateson's Cube: only the moderate bisphosphonate studies appeared to minimise harms to animals whilst being associated with benefit for humans.This is the first time the accountability of the HBA has been systematically explored across a range of pre-clinical animal studies. The regulatory systems in place when these studies were conducted failed to safeguard animals from severe suffering or to ensure that only beneficial, scientifically rigorous research was conducted. Our findings indicate a pressing need to: i. review regulations, particularly those that permit animals to suffer severe harms; ii. reform the processes of prospectively assessing pre-clinical animal studies to make them fit for purpose; and iii. systematically evaluate the benefits of pre-clinical animal research to permit a more realistic assessment of its likely future benefits

    Incorporation of conventional animal welfare assessment techniques into organic certification and farming

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    Providing assurances to consumers on the adherence to certain animal welfare-related standards is an important element of organic and farm assurance schemes. This project has ensured that preliminary welfare assessment protocols developed in a conventional farm assurance system (RSPCA Freedom Food scheme) are available for incorporation into organic (& conventional) certification schemes. The final system (available at www.vetschool.bris.ac.uk/animalwelfare) is an assessment tool that can provide credible (repeatable, valid & feasible) evidence for assessment of compliance with welfare standards in organic and conventional farming systems. For issues identified as causing potential concern the assessor is encouraged to conduct further investigations. This promotes a consistent thorough assessment of relevant resource standards, and where appropriate, management requirements concerning appropriate preventive and corrective action that should be contained within written health plans. Furthermore the assessment tool should enable certification bodies and relevant third parties to monitor the ability of schemes to deliver good welfare outcomes, which is useful for policymakers and consumers wishing to assess the welfare assurance associated with membership of a scheme. Finally it should provide a mechanism for assessing the farm’s own management of health and welfare parameters with their health planning systems which is now a requirement or recommendation of many welfare standards. This should enable farms to both identify their own strengths and weaknesses with respect to welfare and then to monitor any improvements resulting from husbandry changes. This is important as many of the welfare observations also have a significant influence on a farm’s profitability

    Stem Cells

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    Meta-evaluation of the impacts and legacy of the London 2012 Olympic Games and Paralympic Games : Developing methods paper

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    This report brings together the interim findings from the Developing Meta-Evaluation Methods study, which is being undertaken in conjunction with the Meta-Evaluation of the Impacts and Legacy of the London 2012 Olympic Games and Paralympic Games. The work on methods is funded by the Economic and Social Research Council (ESRC). The aim of this paper is to review the existing evidence on conducting meta-evaluation, and provide guidance appropriate to the Meta Evaluation of the Games as well as other meta-evaluation studies

    Welfare benchmarking and herd health plans on organic dairy farms (OF0343)

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    Introduction In response to the recommendations of recent studies on the health and welfare of dairy cattle (Whay et al. 2003) and to assist farmers to meet legislative requirements, promoting farm animal welfare and meeting consumer demand, this study investigated, by means of farmer interviews, the effectiveness of herd health and welfare assessment and benchmarking as a farm management tool. The aims of the study were to • offer support to the organic farming sector and provide detail relevant to all dairy farms utilising herd health plans; • provide information to both organic dairy farmers and their veterinary advisors on the most important elements of herd health plans and the benefits of their effective implementation; and • identify the benefits and constraints to the use and adoption of comparative animal health and welfare assessment as a herd health management tool. From this information, recommendations for practical application and future research would be developed. Other DEFRA funded projects would benefit from findings relevant to their objectives, the development of herd health planning and improvement of farm animal welfare. Objectives As part of a larger study with an objective to carry out health and welfare assessment and benchmarking on organic dairy farms in order to assist farmers and their advisors to identify strengths and weaknesses in herd health and welfare performance, the objectives of this study were to • use qualitative research interviews to a. evaluate farmer responses to the welfare assessment and benchmarking, b. assess the impact and evaluate the effectiveness of the intervention in delivering animal health and welfare improvements and c. as a tool to develop herd health plans for organic systems; • ensure that the results are effectively disseminated to farmers, veterinarians and advisors. Background Benchmarking of production performance has been actively used by many farmers to compare their achievements with those of others and to target areas for improvement with the aim of increasing financial returns from dairy, beef, sheep and other farm enterprises. A protocol to apply this benchmarking concept to farm animal health and welfare has been developed using animal based observations. By observing the animals it becomes possible to compare production systems with different resource provisions, such as quality of flooring, amount of trough space and stocking density, and management approaches. This approach facilitates the identification of strengths and weaknesses in the different management systems assessed and through comparison with others, can demonstrate what it is possible to achieve and where improvements might be made. Qualitative research interviews enable the researcher to gather insights on the interviewee’s perception and opinion. They allow the beliefs and concerns of interviewees to be explored and enable the consistency and weight of the story told to be evaluated. This technique has been used in a range of subject areas including in a farm animal welfare context. However this method for collection of information provides a descriptive account based upon the observations and interpretation of the interview material by the researcher, rather than attempting to quantify opinion or experience. It cannot be used to provide statistically valid numerical data. Summary of assessment and benchmarking process a) Phase 1 During winter 2002 to 2003, 15 organic dairy farms in SW England took part in a herd health and welfare assessment and benchmarking project. The response to the benchmarking process was evaluated by qualitative research interviews. Farmers had implemented changes and requested that there should be a repeat assessment to identify any effect of the changes on cow welfare on their farms. b) Phase 2 In response to this farmer request, fourteen of the fifteen organic dairy farms which had participated in Phase 1 were recruited to Phase 2 of a herd health and welfare assessment and benchmarking study in September 2003. The sample size was increased by the recruitment of a further fourteen new farms following the award of additional funding for the study. On-farm health and welfare assessment and benchmarking of the 28 organic dairy herds was carried out during winter housing period 2003 to 2004. Methodology Semi-structured qualitative research interviews were used to obtain farmer feedback on their participation in comparative assessment of herd health and welfare. Interviews were conducted with all participating farmers between August and November 2004, on a one to one basis on farm either in the house or in the farm office, by the same interviewer. The interviews were recorded onto mini-discs then transcribed in full. Data were analysed using a ‘Grounded Theory’ approach in which common themes across interviews were identified. Results The average length of the research interviews was one hour and fifteen minutes (range thirty minutes to two hours and thirty minutes). Five common and inter-related themes were identified from the farmer interviews: 1. Sensitivities and misgivings Some participants admitted to experiencing feelings of exposure and vulnerability as a result of allowing such a process to be carried out on their herds. Others experienced feelings of shock, failure and disappointment as a result of the assessment outcome. There was considerable concern about the potential for mis-interpretation and mis-use of the results by others outside farming and research circles, particularly if taken out of context and without clear explanation and understanding of the assessment process. Some expressed concerns that that the findings from the assessment and benchmarking might be used in the development of new legislation or that the process might become a requirement of farm quality assurance schemes. 2. Acceptability of scoring methodology and indicators assessed On the whole, the measures used for the assessment were considered to be relevant to herd health and welfare. Farmers were critical of the way in which scores were applied and questioned the relevance, at low/mild levels, of indicators assessed to animal health and welfare. This was particularly true of some scores for mild degrees of dirtiness, lameness and injuries from the environment where the assessment was considered to have been marked ‘severely’, ‘overly critically’ or ‘harshly’. Some were particularly distressed that their efforts to keep their animals clean had apparently failed and were at a loss as to what steps could be taken to improve the situation further. Whilst farmers acknowledged that lameness was a major herd health problem, their initial reactions were of shock and disbelief at the percentage of their cows that were classified as lame on the day of the assessment. Some were of the opinion that if detection of very mild lameness was so difficult, the measure at such a mild level was impractical and had no relevance to day to day management of herd health and welfare. Others considered that where detection and investigation of very mild cases of lameness was possible, it might have some value as a management tool in preventing more serious problems from developing. Injury to hocks, ranging in severity from slight rubbing of the hair to swelling and ulceration was a main focus of farmers’ attention. Although scores given were again at three levels of severity, interestingly there was greater acceptance of the significance of mild levels of incidence of hock injury. Furthermore, the links between hock damage, aspects of the housing environment and lameness were clearly recognised. It was suggested that the assessment should include all dairy animals, from calves, rearing and in calf heifers, dry and milking cows, to bulls. Respondents also considered that the addition of medicine use, fertility and calving indices and mastitis management to the assessment and benchmarking would add value to the process. 3. Raised awareness and motivation to improve Farmers commented that participation in the assessment, had raised their awareness about their animals’ health and welfare and of factors that might affect animal health and welfare within their individual farming systems. Most participants had been keen to affect improvements and had changed at least one element of their system with the aim of better health and welfare for the herd. The main foci for change were the causes of lameness, dirtyness, injuries from the environment mainly involving damage to hocks and necks and condition scoring. There was strong agreement amongst participants that the health and welfare of the cows and financial considerations were the main drivers for change on the farm. Most were of the opinion that the two were inextricably linked in that the health and welfare status of the cows would directly affect performance and therefore financial returns. Constraints to improving animal welfare on farm were largely related to housing issues and lack of finance to implement change in both old cubicle housing and in new and refurbished systems, representing considerable and often recent investment. 4. Veterinary support and herd health planning It was clear that some participants had a very good working relationship with their veterinary advisors. A number of these farms had actively sought out a new veterinary advisor in order to improve the quality of veterinary support for their organic system. Others reported that they were dissatisfied with the service they had received from their veterinary practices and had become reluctant to involve their veterinarians in routine aspects of herd health and welfare management. The degree to which Herd Health Plans had been developed as a useful management tool was clearly linked to the level of interest and quality of veterinary support available to the farmer. 5. Value of assessment and benchmarking With regard to benchmarking, the main focus of attention was on the identification of particular strengths and weaknesses and how improvements to weaker elements might be affected within individual farming systems. Keen to improve their own situation year on year, farmers were interested to learn if management or structural changes they had introduced translated into improvements to herd health and welfare and lead to improved performance within the benchmarking league table. Nevertheless, a number of participants suggested that breed, calving pattern, herd size, housing and other system differences made benchmarking between farms less useful than it might at first appear. Instead they considered that year on year within farm comparison was the more useful measure to determine where progress had been made. Implicit in these comments was the desire to participate in further on-farm health and welfare assessment and to continue the process of improvement into the future. Although farmers suggested a range of timescales from six months to five years, within which repeat assessments should occur, most considered that the interval should be greater than one year. Most considered that the ideal assessor would be a veterinarian with a farm and cattle background. Others thought that whilst a veterinary qualification was probably not essential, the assessor should have a clear understanding of farm animal health and welfare. Farmers voiced concerns over inter-observer reliability. Of utmost concern was that continuity and the validity of any comparison between farms and between years might be lost if more than one person carried out the assessments for a particular group of farms. Recommendations 1. It is recommended that the provision of clear explanation and support is built into all future development and implementation of on-farm welfare assessments to ensure that individuals and groups of farmers fully understand the process in which they participate. 2. It is recommended that • a system of acceptable tolerance levels of welfare indicators is developed in conjunction with a scoring system that applies positive scores to the assessment procedure which takes into account the difficulties of practical application on farm and establishes realistic and achievable goals in welfare improvement. • assessment protocols should only include indicators proven by sound scientific evidence to be appropriate to the goal of improved farm animal health and welfare. 3. There is a requirement for the development of an assessment protocol for calves in order that a complete picture of dairy herd health and welfare can be produced. 4. It is recommended that the need for investigation and clarification of which changes are likely to improve animal welfare and the timescale within which improvements can be expected to occur within farming systems is addressed before widespread implementation of farm animal health and welfare assessment is introduced. 5. It is strongly recommended that an animal welfare payment scheme is introduced to • assist in making improvements in animal welfare • act as an incentive and reward the achievement of improved welfare status, whilst at the same time, • ease the financial burden for farmers. This should be linked to the updating and redevelopment of farm buildings where such action is justified on animal health and welfare grounds. 6. To address this shortfall veterinary training should be expanded to include organic farming principles, preventative and reduced medicine use and homeopathy. 7. It is recommended that in order that such problematic issues are identified, the formation of assessment groups of farms should be supported and encouraged. It is further recommended that areas where difficulties in affecting welfare improvement are experienced should be targeted for further research. 8. A system of training and accreditation of assessors that includes regular monitoring of performance and updating of skills should be developed as an integral part of farm animal health and welfare assessment. 9. A system of training and accreditation of assessors that includes regular monitoring of performance and updating of skills should be developed as an integral part of farm animal health and welfare assessment. It is recommended that the evaluation of the consistency and reliability of welfare assessment over time, and the impacts of potential errors on farming businesses should be made the focus of future research. 10. What is now required is to develop simpler yet robust approaches that enable farmer perception and opinion to be included as key elements in future herd health and welfare endeavours. Clarity of purpose would appear to be an imperative. A starting point may be to examine the approach taken by other disciplines, such as human medicine and environmental management

    Critical assessment issues in work-integrated learning

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    Assessment has long been a contentious issue in work-integrated learning (WIL) and cooperative education. Despite assessment being central to the integrity and accountability of a university and long-standing theories around best practice in assessment, enacting quality assessment practices has proven to be more difficult. Authors in this special issue on assessment highlight the need for balanced assessment approaches that reflect the highly variable experiences students encounter, and the need to keep validity and reliability paramount when constructing assessment structures. Increasingly quality and standards policies driven by more regulatory university environments are impacting on the design of assessment profiles. The value of workplace supervisors’ feedback in WIL contexts is discussed and the challenges of measuring the nuances of unpredictable, context-dependent WIL outcomes are explored. The benefits of ePorftolios are advocated and the use of these platforms as assessment tools that enable a creative way for students to provide evidence of employability capabilities highlighted

    Sustainable seabed mining: guidelines and a new concept for Atlantis II Deep

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    The feasibility of exploiting seabed resources is subject to the engineering solutions, and economic prospects. Due to rising metal prices, predicted mineral scarcities and unequal allocations of resources in the world, vast research programmes on the exploration and exploitation of seabed minerals are presented in 1970s. Very few studies have been published after the 1980s, when predictions were not fulfilled. The attention grew back in the last decade with marine mineral mining being in research and commercial focus again and the first seabed mining license for massive sulphides being granted in Papua New Guinea’s Exclusive Economic Zone.Research on seabed exploitation and seabed mining is a complex transdisciplinary field that demands for further attention and development. Since the field links engineering, economics, environmental, legal and supply chain research, it demands for research from a systems point of view. This implies the application of a holistic sustainability framework of to analyse the feasibility of engineering systems. The research at hand aims to close this gap by developing such a framework and providing a review of seabed resources. Based on this review it identifies a significant potential for massive sulphides in inactive hydrothermal vents and sediments to solve global resource scarcities. The research aims to provide background on seabed exploitation and to apply a holistic systems engineering approach to develop general guidelines for sustainable seabed mining of polymetallic sulphides and a new concept and solutions for the Atlantis II Deep deposit in the Red Sea.The research methodology will start with acquiring a broader academic and industrial view on sustainable seabed mining through an online survey and expert interviews on seabed mining. In addition, the Nautilus Minerals case is reviewed for lessons learned and identification of challenges. Thereafter, a new concept for Atlantis II Deep is developed that based on a site specific assessment.The research undertaken in this study provides a new perspective regarding sustainable seabed mining. The main contributions of this research are the development of extensive guidelines for key issues in sustainable seabed mining as well as a new concept for seabed mining involving engineering systems, environmental risk mitigation, economic feasibility, logistics and legal aspects
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