A Functional Architecture Approach to Neural Systems

The technology for the design of systems to perform extremely complex combinations of real-time functionality has developed over a long period. This technology is based on the use of a hardware architecture with a physical separation into memory and processing, and a software architecture which divides functionality into a disciplined hierarchy of software components which exchange unambiguous information. This technology experiences difficulty in design of systems to perform parallel processing, and extreme difficulty in design of systems which can heuristically change their own functionality. These limitations derive from the approach to information exchange between functional components. A design approach in which functional components can exchange ambiguous information leads to systems with the recommendation architecture which are less subject to these limitations. Biological brains have been constrained by natural pressures to adopt functional architectures with this different information exchange approach. Neural networks have not made a complete shift to use of ambiguous information, and do not address adequate management of context for ambiguous information exchange between modules. As a result such networks cannot be scaled to complex functionality. Simulations of systems with the recommendation architecture demonstrate the capability to heuristically organize to perform complex functionality

Commentary: Prestimulus theta oscillations and connectivity modulate pain perception

Pain experience includes the fine-grain integration of both attentive and automatic (bottom-up; Legrain et al., 2012), as well as affective and intentional (top-down; Buschman and Miller, 2007) processes. While the neural underpinnings of post-stimulus pain processing have been deeply explored (Hauck et al., 2008), the oscillatory brain activity preceding pain processing is less far investigated

Averting HIV Infections in New York City: A Modeling Approach Estimating the Future Impact of Additional Behavioral and Biomedical HIV Prevention Strategies

Background:New York City (NYC) remains an epicenter of the HIV epidemic in the United States. Given the variety of evidence-based HIV prevention strategies available and the significant resources required to implement each of them, comparative studies are needed to identify how to maximize the number of HIV cases prevented most economically.Methods:A new model of HIV disease transmission was developed integrating information from a previously validated micro-simulation HIV disease progression model. Specification and parameterization of the model and its inputs, including the intervention portfolio, intervention effects and costs were conducted through a collaborative process between the academic modeling team and the NYC Department of Health and Mental Hygiene. The model projects the impact of different prevention strategies, or portfolios of prevention strategies, on the HIV epidemic in NYC.Results:Ten unique interventions were able to provide a prevention benefit at an annual program cost of less than $360,000, the threshold for consideration as a cost-saving intervention (because of offsets by future HIV treatment costs averted). An optimized portfolio of these specific interventions could result in up to a 34$106,378; the total cost was in excess of $2 billion (over the 20 year period, or approximately$100 million per year, on average). The cost-savings of prevented infections was estimated at more than $5 billion (or approximately$250 million per year, on average).Conclusions:Optimal implementation of a portfolio of evidence-based interventions can have a substantial, favorable impact on the ongoing HIV epidemic in NYC and provide future cost-saving despite significant initial costs. © 2013 Kessler et al

Optimal Regulation of Auditing

We study regulation of the auditing profession in a model where audit quality is unobservable and enforcing regulation is costly. The optimal audit standard falls short of the first-best audit quality, and is increasing in the riskiness of firms and in the amount of funding they seek. The model can encompass collusion between clients and auditors, arising from the joint provision of auditing and consulting services: deflecting collusion requires less ambitious standards. Finally, banning the provision of consulting services by auditors eliminates collusion but may not be optimal in the presence of economies of scope.auditing, regulation, enforcement, collusion.

Global disease monitoring and forecasting with Wikipedia

Infectious disease is a leading threat to public health, economic stability, and other key social structures. Efforts to mitigate these impacts depend on accurate and timely monitoring to measure the risk and progress of disease. Traditional, biologically-focused monitoring techniques are accurate but costly and slow; in response, new techniques based on social internet data such as social media and search queries are emerging. These efforts are promising, but important challenges in the areas of scientific peer review, breadth of diseases and countries, and forecasting hamper their operational usefulness. We examine a freely available, open data source for this use: access logs from the online encyclopedia Wikipedia. Using linear models, language as a proxy for location, and a systematic yet simple article selection procedure, we tested 14 location-disease combinations and demonstrate that these data feasibly support an approach that overcomes these challenges. Specifically, our proof-of-concept yields models with $r^2$ up to 0.92, forecasting value up to the 28 days tested, and several pairs of models similar enough to suggest that transferring models from one location to another without re-training is feasible. Based on these preliminary results, we close with a research agenda designed to overcome these challenges and produce a disease monitoring and forecasting system that is significantly more effective, robust, and globally comprehensive than the current state of the art.Comment: 27 pages; 4 figures; 4 tables. Version 2: Cite McIver & Brownstein and adjust novelty claims accordingly; revise title; various revisions for clarit