Adaptation of WASH Services Delivery to Climate Change and Other Sources of Risk and Uncertainty

This report urges WASH sector practitioners to take more seriously the threat of climate change and the consequences it could have on their work. By considering climate change within a risk and uncertainty framework, the field can use the multitude of approaches laid out here to adequately protect itself against a range of direct and indirect impacts. Eleven methods and tools for this specific type of risk management are described, including practical advice on how to implement them successfully

Technology Adoption in Poorly Specified Environments

This article extends the characteristics-based choice framework of technology adoption to account for decisions taken by boundedly-rational individuals in environments where traits are not fully observed. It is applied to an agricultural setting and introduces the concept of ambiguity in the agricultural technology adoption literature by relaxing strict informational and cognition related assumptions that are implied by traditional Bayesian analysis. The main results confirm that ambiguity increases as local conditions become less homogeneous and as computational ability, own experience and nearby adoption rates decrease. Measurement biases associated with full rationality assumptions are found to increase when decision makers have low computational ability, low experience and when their farming conditions differ widely from average adopter ones. A complementary empirical paper (Useche 2006) finds that models assuming low confidence in observed data, ambiguity and pessimistic expectations about traits predict sample shares better than models which assume that farmers do not face ambiguity or are optimistic about the traits of new varieties.Research and Development/Tech Change/Emerging Technologies,

Model Selection versus Model Averaging in Dose Finding Studies

Phase II dose finding studies in clinical drug development are typically conducted to adequately characterize the dose response relationship of a new drug. An important decision is then on the choice of a suitable dose response function to support dose selection for the subsequent Phase III studies. In this paper we compare different approaches for model selection and model averaging using mathematical properties as well as simulations. Accordingly, we review and illustrate asymptotic properties of model selection criteria and investigate their behavior when changing the sample size but keeping the effect size constant. In a large scale simulation study we investigate how the various approaches perform in realistically chosen settings. Finally, the different methods are illustrated with a recently conducted Phase II dosefinding study in patients with chronic obstructive pulmonary disease.Comment: Keywords and Phrases: Model selection; model averaging; clinical trials; simulation stud