1,336 research outputs found

    A Review of Generalizability and Transportability

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    When assessing causal effects, determining the target population to which the results are intended to generalize is a critical decision. Randomized and observational studies each have strengths and limitations for estimating causal effects in a target population. Estimates from randomized data may have internal validity but are often not representative of the target population. Observational data may better reflect the target population, and hence be more likely to have external validity, but are subject to potential bias due to unmeasured confounding. While much of the causal inference literature has focused on addressing internal validity bias, both internal and external validity are necessary for unbiased estimates in a target population. This paper presents a framework for addressing external validity bias, including a synthesis of approaches for generalizability and transportability, the assumptions they require, as well as tests for the heterogeneity of treatment effects and differences between study and target populations.Comment: 30 pages, 3 figure

    MULTIVARIATE MODELING OF COGNITIVE PERFORMANCE AND CATEGORICAL PERCEPTION FROM NEUROIMAGING DATA

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    State-of-the-art cognitive-neuroscience mainly uses hypothesis-driven statistical testing to characterize and model neural disorders and diseases. While such techniques have proven to be powerful in understanding diseases and disorders, they are inadequate in explaining causal relationships as well as individuality and variations. In this study, we proposed multivariate data-driven approaches for predictive modeling of cognitive events and disorders. We developed network descriptions of both structural and functional connectivities that are critical in multivariate modeling of cognitive performance (i.e., fluency, attention, and working memory) and categorical perceptions (i.e., emotion, speech perception). We also performed dynamic network analysis on brain connectivity measures to determine the role of different functional areas in relation to categorical perceptions and cognitive events. Our empirical studies of structural connectivity were performed using Diffusion Tensor Imaging (DTI). The main objective was to discover the role of structural connectivity in selecting clinically interpretable features that are consistent over a large range of model parameters in classifying cognitive performances in relation to Acute Lymphoblastic Leukemia (ALL). The proposed approach substantially improved accuracy (13% - 26%) over existing models and also selected a relevant, small subset of features that were verified by domain experts. In summary, the proposed approach produced interpretable models with better generalization.Functional connectivity is related to similar patterns of activation in different brain regions regardless of the apparent physical connectedness of the regions. The proposed data-driven approach to the source localized electroencephalogram (EEG) data includes an array of tools such as graph mining, feature selection, and multivariate analysis to determine the functional connectivity in categorical perceptions. We used the network description to correctly classify listeners behavioral responses with an accuracy over 92% on 35 participants. State-of-the-art network description of human brain assumes static connectivities. However, brain networks in relation to perception and cognition are complex and dynamic. Analysis of transient functional networks with spatiotemporal variations to understand cognitive functions remains challenging. One of the critical missing links is the lack of sophisticated methodologies in understanding dynamics neural activity patterns. We proposed a clustering-based complex dynamic network analysis on source localized EEG data to understand the commonality and differences in gender-specific emotion processing. Besides, we also adopted Bayesian nonparametric framework for segmentation neural activity with a finite number of microstates. This approach enabled us to find the default network and transient pattern of the underlying neural mechanism in relation to categorical perception. In summary, multivariate and dynamic network analysis methods developed in this dissertation to analyze structural and functional connectivities will have a far-reaching impact on computational neuroscience to identify meaningful changes in spatiotemporal brain activities

    Untangling hotel industry’s inefficiency: An SFA approach applied to a renowned Portuguese hotel chain

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    The present paper explores the technical efficiency of four hotels from Teixeira Duarte Group - a renowned Portuguese hotel chain. An efficiency ranking is established from these four hotel units located in Portugal using Stochastic Frontier Analysis. This methodology allows to discriminate between measurement error and systematic inefficiencies in the estimation process enabling to investigate the main inefficiency causes. Several suggestions concerning efficiency improvement are undertaken for each hotel studied.info:eu-repo/semantics/publishedVersio

    An Integrated Fuzzy Inference Based Monitoring, Diagnostic, and Prognostic System

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    To date the majority of the research related to the development and application of monitoring, diagnostic, and prognostic systems has been exclusive in the sense that only one of the three areas is the focus of the work. While previous research progresses each of the respective fields, the end result is a variable grab bag of techniques that address each problem independently. Also, the new field of prognostics is lacking in the sense that few methods have been proposed that produce estimates of the remaining useful life (RUL) of a device or can be realistically applied to real-world systems. This work addresses both problems by developing the nonparametric fuzzy inference system (NFIS) which is adapted for monitoring, diagnosis, and prognosis and then proposing the path classification and estimation (PACE) model that can be used to predict the RUL of a device that does or does not have a well defined failure threshold. To test and evaluate the proposed methods, they were applied to detect, diagnose, and prognose faults and failures in the hydraulic steering system of a deep oil exploration drill. The monitoring system implementing an NFIS predictor and sequential probability ratio test (SPRT) detector produced comparable detection rates to a monitoring system implementing an autoassociative kernel regression (AAKR) predictor and SPRT detector, specifically 80% vs. 85% for the NFIS and AAKR monitor respectively. It was also found that the NFIS monitor produced fewer false alarms. Next, the monitoring system outputs were used to generate symptom patterns for k-nearest neighbor (kNN) and NFIS classifiers that were trained to diagnose different fault classes. The NFIS diagnoser was shown to significantly outperform the kNN diagnoser, with overall accuracies of 96% vs. 89% respectively. Finally, the PACE implementing the NFIS was used to predict the RUL for different failure modes. The errors of the RUL estimates produced by the PACE-NFIS prognosers ranged from 1.2-11.4 hours with 95% confidence intervals (CI) from 0.67-32.02 hours, which are significantly better than the population based prognoser estimates with errors of ~45 hours and 95% CIs of ~162 hours

    CLADAG 2021 BOOK OF ABSTRACTS AND SHORT PAPERS

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    The book collects the short papers presented at the 13th Scientific Meeting of the Classification and Data Analysis Group (CLADAG) of the Italian Statistical Society (SIS). The meeting has been organized by the Department of Statistics, Computer Science and Applications of the University of Florence, under the auspices of the Italian Statistical Society and the International Federation of Classification Societies (IFCS). CLADAG is a member of the IFCS, a federation of national, regional, and linguistically-based classification societies. It is a non-profit, non-political scientific organization, whose aims are to further classification research
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