85,769 research outputs found

    Prospects and limitations of full-text index structures in genome analysis

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    The combination of incessant advances in sequencing technology producing large amounts of data and innovative bioinformatics approaches, designed to cope with this data flood, has led to new interesting results in the life sciences. Given the magnitude of sequence data to be processed, many bioinformatics tools rely on efficient solutions to a variety of complex string problems. These solutions include fast heuristic algorithms and advanced data structures, generally referred to as index structures. Although the importance of index structures is generally known to the bioinformatics community, the design and potency of these data structures, as well as their properties and limitations, are less understood. Moreover, the last decade has seen a boom in the number of variant index structures featuring complex and diverse memory-time trade-offs. This article brings a comprehensive state-of-the-art overview of the most popular index structures and their recently developed variants. Their features, interrelationships, the trade-offs they impose, but also their practical limitations, are explained and compared

    Parallel Finger Search Structures

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    In this paper we present two versions of a parallel finger structure FS on p processors that supports searches, insertions and deletions, and has a finger at each end. This is to our knowledge the first implementation of a parallel search structure that is work-optimal with respect to the finger bound and yet has very good parallelism (within a factor of O(log p)^2) of optimal). We utilize an extended implicit batching framework that transparently facilitates the use of FS by any parallel program P that is modelled by a dynamically generated DAG D where each node is either a unit-time instruction or a call to FS. The work done by FS is bounded by the finger bound F_L (for some linearization L of D), i.e. each operation on an item with distance r from a finger takes O(log r+1) amortized work. Running P using the simpler version takes O((T_1+F_L)/p + T_infty + d * ((log p)^2 + log n)) time on a greedy scheduler, where T_1, T_infty are the size and span of D respectively, and n is the maximum number of items in FS, and d is the maximum number of calls to FS along any path in D. Using the faster version, this is reduced to O((T_1+F_L)/p + T_infty + d *(log p)^2 + s_L) time, where s_L is the weighted span of D where each call to FS is weighted by its cost according to F_L. FS can be extended to a fixed number of movable fingers. The data structures in our paper fit into the dynamic multithreading paradigm, and their performance bounds are directly composable with other data structures given in the same paradigm. Also, the results can be translated to practical implementations using work-stealing schedulers
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